Tackling sepsis-associated AKI: are there any chances of REVIVAL with new approaches?

Prowle, John R.; Bagshaw, Sean M.; Forni, Lui G.

doi:10.1007/s00134-023-07294-3

Cited by 3 publications

(2 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Observed heterogeneity and its impact on MAKE rates, with some studies even lacking a description of applied criteria, are noteworthy and even problematic in study interpretation or comparison and planning RCTs. [142,143] The concept of MAKE was originally proposed by Shaw in 2011 [144] as a patient-centered renal outcome including death, new dialysis, and incident or progressive chronic kidney disease. Subsequently, it was operationalized to include death, dialysis, and persistent renal dysfunction in most articles.…”

Section: Relationship To Previous Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Heterogeneity in the definition of major adverse kidney events: a scoping review

Maeda,

Inokuchi,

Bellomo

et al. 2024

Intensive Care Med

View full text Add to dashboard Cite

Acute kidney injury (AKI) is associated with persistent renal dysfunction, the receipt of dialysis, dialysis dependence, and mortality. Accordingly, the concept of major adverse kidney events (MAKE) has been adopted as an endpoint for assessing the impact of AKI. However, applied criteria or observation periods for operationalizing MAKE appear to vary across studies. To evaluate this heterogeneity for MAKE evaluation, we performed a systematic scoping review of studies that employed MAKE as an AKI endpoint. Four major academic databases were searched, and we identified 122 studies with increasing numbers over time. We found marked heterogeneity in applied criteria and observation periods for MAKE across these studies, with some even lacking a description of criteria. Moreover, 13 different observation periods were employed, with 30 days and 90 days as the most common. Persistent renal dysfunction was evaluated by estimated glomerular filtration rate (34%) or serum creatinine concentration (48%); however, 37 different definitions for this component were employed in terms of parameters, cut-off criteria, and assessment periods. The definition for the dialysis component also showed significant heterogeneity regarding assessment periods and duration of dialysis requirement (chronic vs temporary). Finally, MAKE rates could vary by 7% [interquartile range: 1.7-16.7%] with different observation periods or by 36.4% with different dialysis component definitions. Our findings revealed marked heterogeneity in MAKE definitions, particularly regarding component assessment and observation periods. Dedicated discussion is needed to establish uniform and acceptable standards to operationalize MAKE in terms of selection and applied criteria of components, observation period, and reporting criteria for future trials on AKI and related conditions.

show abstract

Section: Relationship To Previous Studiesmentioning

confidence: 99%

“…In response, the need for standardized MAKE definitions and the risk of applying different definitions in RCTs were highlighted in the accompanying editorial. [142]…”

Section: Relationship To Previous Studiesmentioning

confidence: 99%

Heterogeneity in the definition of major adverse kidney events: a scoping review

Maeda,

Inokuchi,

Bellomo

et al. 2024

Intensive Care Med

View full text Add to dashboard Cite

show abstract

The dysfunction of complement and coagulation in diseases: the implications for the therapeutic interventions

Jiang,

Guo,

Wang

et al. 2024

MedComm

View full text Add to dashboard Cite

The complement system, comprising over 30 proteins, is integral to the immune system, and the coagulation system is critical for vascular homeostasis. The activation of the complement and coagulation systems involves an organized proteolytic cascade, and the overactivation of these systems is a central pathogenic mechanism in several diseases. This review describes the role of complement and coagulation system activation in critical illness, particularly sepsis. The complexities of sepsis reveal significant knowledge gaps that can be compared to a profound abyss, highlighting the urgent need for further investigation and exploration. It is well recognized that the inflammatory network, coagulation, and complement systems are integral mechanisms through which multiple factors contribute to increased susceptibility to infection and may result in a disordered immune response during septic events in patients. Given the overlapping pathogenic mechanisms in sepsis, immunomodulatory therapies currently under development may be particularly beneficial for patients with sepsis who have concurrent infections. Herein, we present recent findings regarding the molecular relationships between the coagulation and complement pathways in the advancement of sepsis, and propose potential intervention targets related to the crosstalk between coagulation and complement, aiming to provide more valuable treatment of sepsis.

show abstract

‘Reviving’ the call for standardization of the composite outcome of major adverse kidney events in critical care nephrology research

Flannery,

Woodward,

Barreto

et al. 2024

Intensive Care Med

View full text Add to dashboard Cite

Tackling sepsis-associated AKI: are there any chances of REVIVAL with new approaches?

Cited by 3 publications

References 7 publications

Heterogeneity in the definition of major adverse kidney events: a scoping review

Heterogeneity in the definition of major adverse kidney events: a scoping review

The dysfunction of complement and coagulation in diseases: the implications for the therapeutic interventions

‘Reviving’ the call for standardization of the composite outcome of major adverse kidney events in critical care nephrology research

Contact Info

Product

Resources

About