Tackling the Aging Process With Bio-Molecules: A Possible Role for Caloric Restriction, Food-derived Nutrients, Vitamins, Amino Acids, Peptides, and Minerals

Abstract

Aging is a multifactorial process leading to general deterioration in many tissues and organs, accompanied by an increased incidence and severity of a wide variety of chronic, incurable, and often fatal diseases. A possibility of slowing down the aging process and improving the quality of life in old age by nutritional intervention has renewed the interest of the scientific world in anti-aging therapies. These include potential dietary interventions, adherence to nutrition, hormonal and cell-based therapies, genetic manipulations, and anti-aging supplements or nutrients. This review addresses strategies to slow the aging process by caloric restriction and the use of nutritional supplements.

Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases

“…Thus, understanding the basis of the molecular effects of aging may help to reveal important aspects of organismal aging, as well as processes that lead to age-related dysfunction for developing therapeutic interventions (Jiang et al, 2001;Bishop et al, 2010). In addition, a number of healthy lifestyles and anti-aging therapies that can reduce or delay the physiological decline and age-related disease progression have been documented Dabhade and Kotwal, 2013).…”

“…Aging is a universal, intrinsic, progressive and multifactorial process characterized as degenerative in nature, which causes progressive loss of function and an increased risk of death (Acuña-Castroviejo et al, 2001;Mandavilli et al, 2002;Viña et al, 2007;Dabhade and Kotwal, 2013;López-Otín et al, 2013;Shokolenko et al, 2014). Aging occurs in spite of complex pathways for maintenance, repair and defense; this process progressively develops in every individual that survives beyond a certain duration of life within the evolutionary framework (Rattan, 2014).…”

Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases

“…Age-related diseases have become the greatest health threats in the twenty-first century. Aging is an intrinsic, universal, multifactorial, and progressive process characterized as degenerative in nature, accompanied by progressive loss of function and ultimately increased mortality rate (Dabhade and Kotwal, 2013 ; López-Otín et al, 2013 ; Shokolenko et al, 2014 ; Chang et al, 2017 ). Among the theories that explain the aging process, the free radical theory of aging is long-established (Harman, 1956 ).…”

Rat Hepatocyte Glucose Metabolism Is Affected by Caloric Restriction but not by Litter Size Reduction

“…This work aimed at investigating whether the liver glucose metabolism could have a role in any change of glucose homeostasis that might be present in the reduced-litter rat at the age of 60 days. Additionally, post-weaning caloric restriction and its hepatic effects were explored, as this intervention is reported as a useful measure against obesity and its related disturbances [8][9][10][11][12][13]27].…”