“…Tendon graft-to-bone tunnel integration after ACLR involves slow biological processes consisting of three key healing processes and requires more than 12 months for graft maturation [ [13] , [14] , [15] , [16] , [17] ]. Therefore, there has been substantial interest in exploring biological strategies, including drugs, growth factors, platelet-rich plasma (PRP), stem cells, stem cell-conditioned media, biomaterials, and biophysical interventions, to facilitate tendon graft-to-bone tunnel integration and promote earlier graft maturation, which may allow earlier recovery and earlier return to play [ [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] ].…”