Centralized urban water management currently faces multiple challenges, both at the supply side and the demand side. These challenges underpin the need to progress to the decentralization of urban water, where multiple distributed technologies (water-aware appliances, rainwater harvesting, greywater recycling, sustainable urban drainage) are applied in an integrated fashion and as a supplement to centralized systems to design more resilient neighborhoods. However, the methods and tools to assess the performance of these distributed solutions and provide management support for integrated projects are still few and mostly untested in real, combined cases. This study presents a simulation-based framework for the quantitative performance assessment of decentralized systems at a neighborhood scale, where different technologies can be linked together to provide beneficial effects across multiple urban water cycle domains. This framework links an urban water cycle model, which provides a scenario-based simulation testbed for the response of the whole system, with key performance indicators that evaluate the performance of integrated decentralized solutions at a neighborhood scale. The demonstrated framework is applied to provide an ex ante evaluation of SUPERLOCAL, a newly developed area in Limburg, the Netherlands, designed as a circular, water-wise neighborhood where multiple decentralized technologies are combined.