Tacrolimus has immunosuppressive effects on heavy/light chain pairs and free light chains in patients after heart transplantation: A relationship with infection

Lavríková, Petra; Sečník, Peter; Kubíček, Zdenĕk; Jabor, Antonı́n; Hošková, Lenka; Franeková, Janka

doi:10.1016/j.trim.2018.06.005

Cited by 2 publications

(13 citation statements)

References 13 publications

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“…In general, a statistically significant decrease in sFLCs, sHLC IgA, and sHLC IgG in the 9th month after HTX was noted 59 . However, the serum FLC ratio was the lowest in the 18th month of follow‐up 59 . Nine patients had an infection in the 9th month after HTX, most commonly affecting the upper respiratory tract or urinary tract 59 .…”

Section: Methodsmentioning

confidence: 98%

“…It was suggested that decreased concentrations of sFLCs along with immunoglobulin heavy chain/light chain (sHLC) pairs can serve as biomarkers of increased risk of infection in patients after heart transplantation (HTX) 59 . Eighty‐eight patients with a median age of 54 years, who were after HTX were treated with triple tacrolimus‐based immunosuppressive scheme 59 . The most intensive therapy with tacrolimus was during the first nine months after HTX 59 .…”

Section: Methodsmentioning

confidence: 99%

“…Eighty‐eight patients with a median age of 54 years, who were after HTX were treated with triple tacrolimus‐based immunosuppressive scheme 59 . The most intensive therapy with tacrolimus was during the first nine months after HTX 59 . The sFLCs and sHLC levels were assessed at four‐time points: before HTX and 9, 18, and 24 months after HTX 59 .…”

Section: Methodsmentioning

confidence: 99%

“…The most intensive therapy with tacrolimus was during the first nine months after HTX 59 . The sFLCs and sHLC levels were assessed at four‐time points: before HTX and 9, 18, and 24 months after HTX 59 . In general, a statistically significant decrease in sFLCs, sHLC IgA, and sHLC IgG in the 9th month after HTX was noted 59 .…”

Section: Methodsmentioning

confidence: 99%

“…The sFLCs and sHLC levels were assessed at four‐time points: before HTX and 9, 18, and 24 months after HTX 59 . In general, a statistically significant decrease in sFLCs, sHLC IgA, and sHLC IgG in the 9th month after HTX was noted 59 . However, the serum FLC ratio was the lowest in the 18th month of follow‐up 59 .…”

Section: Methodsmentioning

confidence: 99%

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Serum free light chains in solid organ transplant recipients

Kwapisz

2021

Clinical Transplantation

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Immunoglobulin is built by a pair of identical heavy and a pair of identical light chains. Light chains are produced in excess compared to heavy chains. Free light chains (FLCs) are those which are not combined with heavy chains. Currently, numerous assays are available for the measurement of serum FLCs (sFLCs). These assays cannot be used interchangeably, and renal function should be taken into account in interpreting test results. Levels of kappa and lambda sFLCs are usually used to diagnose and monitor plasma cell dyscrasias. However, the clinical relevance of sFLCs is being investigated in patients with a variety of diseases, including patients after transplantation. There are contradictory results regarding the usefulness of sFLCs in the prediction of post‐transplant lymphoproliferative disorder (PTLD). However, it seems that sFLCs may be helpful in the prediction of early‐onset PTLD. Some studies have shown that low levels of sFLCs are associated with a higher risk of infection in patients after transplantation. This review summarizes and highlights recent advances in the utility of sFLCs in the prediction of PTLD and infection, and inflammation assessment in patients after solid organ transplantation. Moreover, the influence of immunosuppressive treatment on sFLCs levels is described briefly.

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Section: Methodsmentioning

confidence: 98%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Serum free light chains in solid organ transplant recipients

Kwapisz

2021

Clinical Transplantation

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Overcoming the Anatomical and Physiological Barriers in Topical Eye Surface Medication Using a Peptide-Decorated Polymeric Micelle

Lin¹,

Ge²,

Wang³

et al. 2019

ACS Appl. Mater. Interfaces

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The sealed anatomical features of the eye and its physiological activity that rapidly removes drugs are called anatomical and physiological barriers, which are the cause of more than 90% of drug loss. This aspect remains a critical issue in eye surface medication. Thus, promoting tissue permeability of drugs as well as prolonging their retention on the eye surface can improve their bioavailability and enhance their therapeutic effects. Thanks to the existence of a negatively charged mucin layer on the eye surface, several peptide-decorated polymeric micelles were prepared to enhance the interaction between the micelle and eye surface, thus prolonging the drug retention on the eye surface and promoting its tissue permeability. Tacrolimus (also known as FK506) is a hydrophobic macrolide immunosuppressant used to treat dry eye syndrome and other eye diseases. However, its hydrophobic nature makes its delivery as a topical eye surface medication difficult, with the risk of side effects due to overdoses. Therefore, the aim of this work is to evaluate the ability of FK506 micelles in promoting their permeability on the eye surface. Our results showed that the positively charged nanomicelles could significantly prolong FK506 retention on the eye surface and enhance its corneal permeability in ex vivo and in vivo conditions. FK506 nanomicelles exhibited superior curing effects against dry eye diseases than the FK506 suspension and a commercial FK506 formula. It exerted better inhibitory effects on eye surface inflammation and corneal epithelium apoptosis when examined by a slip lamp and a transferase-mediated dUTP nick end labeling assay, respectively. Further assays revealed the higher suppressive effects on the expression of several inflammation-related factors at an mRNA and protein level. Hence, our results suggested that these positively charged nanomicelles might be a good drug delivery system for ocular surface medication.

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Tacrolimus has immunosuppressive effects on heavy/light chain pairs and free light chains in patients after heart transplantation: A relationship with infection

Cited by 2 publications

References 13 publications

Serum free light chains in solid organ transplant recipients

Serum free light chains in solid organ transplant recipients

Overcoming the Anatomical and Physiological Barriers in Topical Eye Surface Medication Using a Peptide-Decorated Polymeric Micelle

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