Tacrolimus-loaded lecithin-based nanostructured lipid carrier and nanoemulsion with propylene glycol monocaprylate as a liquid lipid: Formulation characterization and assessment of dermal delivery compared to referent ointment

Savić, Vedrana; Ilić, Tanja; Nikolić, Ines; Marković, Bojan; Čalija, Bojan; Cekić, Nebojša; Savić, Snežana

doi:10.1016/j.ijpharm.2019.118624

Cited by 40 publications

(23 citation statements)

References 41 publications

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“…In the example of the skin disease acne, it has been assumed that occluded hair follicles under ferment ation conditions metabolize lipid-enriched materials secreted from sebaceous glands into SCFAs. Because the lipid-enriched molecules are able to be retained in the epidermis or stratum corneum (45), SCFAs in hair follicles at sufficient concentrations can then exert cell-dominant effects on the keratinocytes rather than the dermal cells. From the perspective of microbial ecology, production of SCFAs might have some advantages for commensal bacteria to survive at the expense of other bacteria if an increased host inflammatory response selectively targets the competition.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous innate immune tolerance is mediated by epigenetic control of MAP2K3 by HDAC8/9

et al. 2021

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The skin typically tolerates exposure to various microbes and chemicals in the environment. Here, we investigated how the epidermis maintains this innate immune tolerance to stimuli that are recognized by Toll-like receptors (TLRs). Loss of tolerance to TLR ligands occurred after silencing of the histone deacetylases (HDACs) HDAC8 and HDAC9 in keratinocytes. Transcriptional analysis identified MAP2K3 as suppressed by HDAC8/9 activity and a potential key intermediary for establishing this tolerance. HDAC8/9 influenced acetylation at H3K9 and H3K27 marks in the MAP2K3 promoter. Proteomic analysis further identified SSRP1 and SUPT16H as associated with HDAC8/9 and responsible for transcriptional elongation of MAP2K3. Silencing of MAP2K3 blocked the capacity of HDAC8/9 to influence cytokine responses. Relevance in vivo was supported by observations of increased MAP2K3 in human inflammatory skin conditions and the capacity of keratinocyte HDAC8/9 to influence dendritic cell maturation and T cell proliferation. Keratinocyte-specific deletion of HDAC8/9 also increased inflammation in mice after exposure to ultraviolet radiation, imiquimod, or Staphylococcus aureus. These findings define a mechanism for the epidermis to regulate inflammation in the presence of ubiquitous TLR ligands.

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Section: Discussionmentioning

confidence: 99%

Cutaneous innate immune tolerance is mediated by epigenetic control of MAP2K3 by HDAC8/9

et al. 2021

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“…Glycerophospholipids, such as phosphatidylcholine, exhibit amphiphilic structures [23], and can be used as inactive ingredients to form novel mixtures for smoothing food textures, emulsifying, homogenizing liquid mixtures, and repelling sticking materials. Indeed, lecithin has been applied extensively in nanoscale drug delivery systems in recent years [24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Lecithin-Based Dermal Drug Delivery for Anti-Pigmentation Maize Ceramide

et al. 2020

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Ceramides have several well-known biological properties, including anti-pigmentation and anti-melanogenesis, which make them applicable for use in skincare products in cosmetics. However, the efficacy of ceramides is still limited. Dermal or transdermal drug delivery systems can enhance the anti-pigmentation properties of ceramides, although there is currently no systemic evaluation method for the efficacy of these systems. Here we prepared several types of lecithin-based emulsion of maize-derived glucosylceramide, determining PC70-ceramide (phosphatidylcholine-base) to be the safest and most effective anti-pigmentation agent using zebrafish larvae. We also demonstrated the efficacy of PC70 as a drug delivery system by showing that PC70-Nile Red (red fluorescence) promoted Nile Red accumulation in the larval bodies. In addition, PC70-ceramide suppressed melanin in mouse B16 melanoma cells compared to ceramide alone. In conclusion, we developed a lecithin-based dermal delivery method for ceramide using zebrafish larvae with implications for human clinical use.

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“…As PS was impacted positively with increase in liquid lipid concentration we would expect an increase in PDI at higher concentrations of oil due to the increase in the agglomeration of the particles as a consequence of the Van der Waal attraction forces resulting in polydisperse formulations [23]. However, in exception to the two propylene glycol esters, PGMC and PGML which showed positive correlation, other liquid lipids either did not have much impact or resulted in formation of more homogeneous NLCs with increase in liquid lipid [35]. This is also evident from steep curvature of the RES-PGMC and RES-PGML in the perturbation plots signifying their higher influence on PDI (Figure 3.b).…”

Section: Influence Of Investigated Parameters On Pdimentioning

confidence: 93%

Impact of liquid lipid on development and stability of trimyristin nanostructured lipid carriers for oral delivery of resveratrol

Houacine

Adams

Singh

2020

Journal of Molecular Liquids

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Tacrolimus-loaded lecithin-based nanostructured lipid carrier and nanoemulsion with propylene glycol monocaprylate as a liquid lipid: Formulation characterization and assessment of dermal delivery compared to referent ointment

Cited by 40 publications

References 41 publications

Cutaneous innate immune tolerance is mediated by epigenetic control of MAP2K3 by HDAC8/9

Cutaneous innate immune tolerance is mediated by epigenetic control of MAP2K3 by HDAC8/9

Lecithin-Based Dermal Drug Delivery for Anti-Pigmentation Maize Ceramide

Impact of liquid lipid on development and stability of trimyristin nanostructured lipid carriers for oral delivery of resveratrol

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