Tacrolimus ointment promotes repigmentation of vitiligo in children: A review of 57 cases

Efficacy and Safety of Topical Tacrolimus (0.03%) in the Treatment Localized Vitiligo

“…Most common side effects were erythema and burning. This result is supported by various other studies 22,24 .…”

“…This result is largely differ from Silverberg et al 22 This result is also differ from Lepe et al 25 where they found tacrolimus produce more than 75% repigmentation, most of this on facial areas. The probable causes of the difference is the concentration difference of tacrolimus 0.03% vs 0.1%.…”

“…This result is different from Silverberg et al 22 They studied three group of patients; one group had lesions on the head & neck area; one group had lesions on the trunk & extremities; one group had lesions head, neck, trunk & extremities. Furthermore they studied with two different strength of tacrolimus ointment.…”

“…From the present study it has been found that overall 83.3% of the patients responded positively to therapy. Silverberg et al support this result 22 .…”

Role of Corticosteroids in Treatment of Vitiligo

“…They can be used as a treatment of choice for the vitiligo lesions on the head and neck, especially when the disease is long lasting (Berti et al, 2009). The treatment response of segmental vitiligo is appropriate to calcineurin inhibitors (Kakouro, 2009;Silverberg et al, 2004).…”