2013
DOI: 10.1016/j.jceh.2013.03.192
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Tacrolimus related adverse effects in liver transplant recipients: Its association with trough concentrations

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Cited by 2 publications
(2 citation statements)
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“…It has a narrow therapeutic index requiring frequent therapeutic drug monitoring to maintain concentrations within the therapeutic range. Subtherapeutic concentrations in the early post‐transplant period increase the risk of rejection, while concentrations above the target range contribute to drug‐related toxicity …”
Section: Introductionsupporting
confidence: 67%
“…It has a narrow therapeutic index requiring frequent therapeutic drug monitoring to maintain concentrations within the therapeutic range. Subtherapeutic concentrations in the early post‐transplant period increase the risk of rejection, while concentrations above the target range contribute to drug‐related toxicity …”
Section: Introductionsupporting
confidence: 67%
“…However, systemically delivered FK506 may cause severe side effects including nephrotoxicity and global immunosuppression, potentially resulting in undesirable, debilitating consequences if used clinically following nerve repair (Udina et al, ; Varghese et al, ; Yamazoe et al, ). Thus, sustained localized delivery is required for a broad clinical use of FK506 to enhance nerve regeneration (Konofaos and Terziss, ).…”
Section: Introductionmentioning
confidence: 99%