Tactile-like corpuscles in gastric mucosa: a case report

Salim, Sadia; Beiqing, Liu; Mahmoodi, Mandana; Asad, Haider; Hou, Steve

doi:10.1186/1477-7819-4-39

Cited by 10 publications

(6 citation statements)

References 8 publications

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“…7 It was found to be associated with some peripheral nerve sheath tumors, namely, traumatic neuroma, neurofibroma, neurilemmoma, and melanocytic nevi. 7 Interestingly, Fellegara et al reported an ovarian mature cystic teratoma with florid vascular proliferation and Wagner-Meissner-like corpuscles. 8 In the colon, De Beca et al observed a Schwann cell hamartoma with tactoid body features presented endoscopically as a polyp.…”

Section: Discussionmentioning

confidence: 99%

“…It has been named with different descriptive names, including tactoid bodies, Wagner-Meissner-like corpuscles, Pacinian corpuscles-like structures, and pseudomeissnerian corpuscles. 7 It was found to be associated with some peripheral nerve sheath tumors, namely, traumatic neuroma, neurofibroma, neurilemmoma, and melanocytic nevi. 7 Interestingly, Fellegara et al reported an ovarian mature cystic teratoma with florid vascular proliferation and Wagner-Meissner-like corpuscles.…”

Section: Discussionmentioning

confidence: 99%

“…Two cases were associated with adenocarcinoma on colon resection and esophagogastrectomy. 2,7 Six cases were positive for Barret esophagus, active and inactive chronic gastritis, enterochromaffin-like cell hyperplasia, gastric intestinal metaplasia, and quiescent inflammatory bowel disease. 3,4 None of the reported cases was associated with a syndromic setting, such as neurofibromatosis 1, multiple neuroendocrine IIB (MENIIB).…”

Section: Discussionmentioning

confidence: 99%

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Gastrointestinal Tactile Corpuscle-Like Bodies: Report of Two Cases and Review of the Literature

Mobarki,

Musawi,

Alibrahim

et al. 2023

Int J Surg Pathol

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Gastrointestinal tactile corpuscle-like bodies are a rare, incidental, entirely benign finding. It is mainly reported in the colorectum and esophagus/gastro-esophageal junction. Rare cases have been documented in the stomach. Here, we present two cases of gastric and colonic tactile corpuscle-like bodies of a 38-year-old female and a 55-year-old male, respectively. Endoscopically, the colonic lesion was resected as an adenomatous polyp, while the gastric biopsies were taken to rule out Helicobacter pylori ( H. pylori) gastritis. Microscopically, both specimens revealed the same histopathologic aspects of eosinophilic fibrillary material with round to oval cells and peripherally placed nuclei. Immunohistochemically, these lesions were positive for anti-S100, confirming the diagnosis of tactile corpuscle-like bodies. A thorough literature review is provided.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Gastrointestinal Tactile Corpuscle-Like Bodies: Report of Two Cases and Review of the Literature

Mobarki,

Musawi,

Alibrahim

et al. 2023

Int J Surg Pathol

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“…TCLBs have also been described in the literature as Wagner-Meissner-like corpuscles, Wagner-Meissner bodies, pseudo-Meissner corpuscles, and Meissneroid corpuscles [ 2 ]. The gastrointestinal (GI) tract is normally devoid of TCLB and, if present, they are rare findings, mostly found on incidental GI endoscopies [ 3 , 4 ]. They are believed to be reparative neural proliferation and are deemed benign with an excellent prognosis [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…A tumor with TCLB in its entirety has also been reported in the periaortic tissue, extremities, and vulva [ 3 ]. A TCLB-associated GI tumor is unusual and almost always an incidental finding [ 3 , 4 ]. When present, they appear as spindle cells in the lamina propria [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Colon Conundrum: A Fascinating Case Report Unraveling the Enigmatic Tactoid Bodies

Gofar,

Yearsley,

Gallardo

et al. 2023

Cureus

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Tactile corpuscle-like bodies (TCLBs) are specialized mechanoreceptors found in the dermal papilla of glabrous skin. They are normally not found in the gastrointestinal (GI) mucosa. There has been an increase in incidental detection in the GI mucosa due to the widespread use of colonoscopy procedures. However, TCLB's clinical implications in the GI tract remain unknown. We present a case of a 74-year-old man who was noted to have TCLBs in the rectosigmoid mucosa following resection for iatrogenic perforation. The TCLBs were spindle-shaped, positive for S-100, and negative for CD68. We review the literature on TCLBs in the GI tract and discuss their potential function in the GI mucosa.

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Tactile Corpuscle-like Bodies in Gastrointestinal-type Mucosa

Celeiro-Muñoz¹,

Huebner

Robertson

et al. 2015

American Journal of Surgical Pathology

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Tactile corpuscle-like bodies (TCLB) are microscopic Schwannian structures that simulate the superficial mechanoreceptors of the peripheral nervous system (Wagner-Meissner corpuscles). They have been described nearly exclusively in peripheral nerve sheath tumors, namely diffuse neurofibromas, and schwannomas but also in cellular nevi. There are rare reports of these structures in the gastrointestinal tract (predominantly the lower tract), with the presumption that they are incidental reactive neural proliferations. We compiled 9 cases showing this rare phenomenon in gastrointestinal-type mucosa in nonsyndromic patients to further characterize its features. There were 6 men and 3 women (age range, 39 to 79 y, mean 56 y) with lesions involving esophagus/gastro-esophageal junction (n=7), sigmoid colon (n=1), and gastric heterotopia of the cricopharynx (n=1). Endoscopic examination was abnormal in 6 of the 7 cases (including changes consistent with Barrett esophagus and polypoid/nodular mucosa) and normal in 1 of 7 cases for which this information was available. The histologic features were similar in all cases, with unencapsulated clusters of lamellated and concentrically arranged spindle cells in the lamina propria. The foci of TCLB ranged in size from <0.1 to 1.5 mm in the greatest dimension. Abnormal histopathologic findings were identified in the background mucosa in 6 of 9 cases (including Barrett esophagus, active and inactive chronic gastritis, enterochromaffin-like cell hyperplasia, and gastric intestinal metaplasia). None of the patients showed signs of neurofibromatosis type 1, multiple endocrine neoplasia type 2B, Cowden syndrome, or other inherited syndrome. No morbidity related to TCLB was reported for the patients with available follow-up.

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Tactile-like corpuscles in gastric mucosa: a case report

Abstract: Background: The presence of tactile corpuscle-like structures in Schwannomas, Neurofibromas and Neuroid Intradermal Melanocytic Nevi is well-documented. We report a case describing the presence of such structures in the lamina propria of grossly normal gastric mucosa.

Cited by 10 publications

References 8 publications

Gastrointestinal Tactile Corpuscle-Like Bodies: Report of Two Cases and Review of the Literature

Gastrointestinal Tactile Corpuscle-Like Bodies: Report of Two Cases and Review of the Literature

Colon Conundrum: A Fascinating Case Report Unraveling the Enigmatic Tactoid Bodies

Tactile Corpuscle-like Bodies in Gastrointestinal-type Mucosa

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