Tactile response adaptation to whisker stimulation in the lemniscal somatosensory pathway of rats

Martín-Cortecero, Jesús; Núñez, Ángel

doi:10.1016/j.brainres.2014.10.002

Cited by 18 publications

(20 citation statements)

References 77 publications

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“…A prominent feature of sensory adaptation is that the degree of response attenuation is linked to the rate of sensory stimulation: higher frequency stimulation leads to stronger amplitude attenuation (Chung et al, 2002;Khatri et al, 2004;Kheradpezhouh., 2017;Martin-Cortecero & Nuñez, 2014). We find this common pattern in our V1, S1 and A1 responses (Fig.…”

Section: Response Attenuation With Stimulus Frequencysupporting

confidence: 70%

“…This may differ by sensory system, as a recent study using fiber photometry failed to find a termination (or echo) response in the auditory thalamus (Li et al, 2017). Both the biphasic response to individual pulses (or low frequency stimulation) and response attenuation at high stimulus frequencies have also been reported subcortically (Chung et al, 2002;Funayama et al, 2016;Martin-Cortecero, J. & Nuñez, A., 2014).…”

Section: Discussionmentioning

confidence: 98%

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Multiple timescales account for adaptive responses across sensory cortices

Latimer¹,

Barbera²,

Sokoletsky³

et al. 2019

Preprint

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Sensory systems encounter remarkably diverse stimuli in the external environment. Natural stimuli exhibit timescales and amplitudes of variation that span a wide range. Mechanisms of adaptation, ubiquitous feature of sensory systems, allow for the accommodation of this range of scales. Are there common rules of adaptation across different sensory modalities? We measured the membrane potential responses of individual neurons in the visual, somatosensory and auditory cortices to discrete, punctate stimuli delivered at a wide range of fixed and nonfixed frequencies. We find that the adaptive profile of the response is largely preserved across these three areas, exhibiting attenuation and responses to the cessation of stimulation which are signatures of response to changes in stimulus statistics. We demonstrate that these adaptive responses can emerge from a simple model based on the integration of fixed filters operating over multiple time scales.

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Section: Response Attenuation With Stimulus Frequencysupporting

confidence: 70%

Section: Discussionmentioning

confidence: 98%

Multiple timescales account for adaptive responses across sensory cortices

Latimer¹,

Barbera²,

Sokoletsky³

et al. 2019

Preprint

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show abstract

“…When the fatigue mechanisms revealed in the above in-vitro studies contribute to repetition suppression, one would expect that repetition suppression decreases when acetylcholine is augmented. In line with this hypothesis, local intracerebral application of acetylcholine has been reported to reduce but not abolish adaptation in anesthetized rodent colliculus inferior 14 and somatosensory (barrel) cortex 15 . In contrast to these studies in non-visual regions of rodents, a human fMRI study 16 showed increased repetition suppression in inferior occipital cortex for faces with systemic application of the cholinesterase inhibitor physostigmine, and no region showed an attenuation of repetition suppression under physostigmine.…”

Section: Introductionmentioning

confidence: 70%

“…Indeed, for both ACh 14,15 and GAB 18,19 , previous studies in rodents showed decreased stimulus selective adaptation. In these studies, repetition suppression was still present with drug application and it is unclear whether the smaller adaptation indices did not result from increased responses per se since raw instead of net responses were employed to compute adaptation indices (except for one control analysis in 14 ).…”

Section: Discussionmentioning

confidence: 86%

GABAergic and cholinergic modulation of repetition suppression in inferior temporal cortex

Kuravi

Vogels

2018

Sci Rep

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Neurons in many brain areas of different species reduce their response when a stimulus is repeated. Such adaptation or repetition suppression is prevalent in inferior temporal (IT) cortex. The mechanisms underlying repetition suppression in IT are still poorly understood. Studies in rodents and in-vitro experiments suggest that acetylcholine and GABA can contribute to repetition suppression by interacting with fatigue-related or local adaptation mechanisms. Here, we examined the contribution of cholinergic and GABAergic mechanisms to repetition suppression in macaque IT, using an adaptation paradigm in which familiar images were presented successively with a short interstimulus interval. We found that intracortical local injections of acetylcholine and of the GABAA receptor antagonist Gabazine both increased repetition suppression in awake macaque IT. The increased repetition suppression was observed for both spiking activity and local field potential power. The latter was present mainly for frequencies below 50 Hz, spectral bands that typically do not show consistent repetition suppression in IT. Although increased with drug application, repetition suppression remained stimulus selective. These findings agree with the hypothesis that repetition suppression of IT neurons mainly results from suppressed input from upstream and other IT neurons but depend less on intrinsic neuronal fatigue.

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“…The 30‐ and 125‐ms delays were chosen because the somatosensory activation within the SI is assumed to persist for at least 60 ms (Allison et al ., ; Mauguière et al ., ) and its signal recovery time has been reported to be about 110 ms (Hamada et al ., ). Thus, in the 30‐ms condition the processing of both stimuli overlapped within the SI (Chung et al ., ; Martin‐Cortecero & Nuñez, ; Nakagawa et al ., ), whereas in the 125‐ms condition the first stimulus is processed by the SI before the second stimulus arrives and therefore the stimuli interact at later stages, most likely in the secondary somatosensory cortex (SII) or the parietal cortex. The rationale behind these specific timings comes from the different retention times of the somatosensory signal in the SI.…”

Section: Methodsmentioning

confidence: 99%

Somatotopy and temporal dynamics of sensorimotor interactions: evidence from double afferent inhibition

Tamè

Pavani

Braun

et al. 2015

Eur J of Neuroscience

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Moving and interacting with the world requires that the sensory and motor systems share information, but while some information about tactile events is preserved during sensorimotor transfer the spatial specificity of this information is unknown. Afferent inhibition (AI) studies, in which corticospinal excitability (CSE) is inhibited when a single tactile stimulus is presented before a transcranial magnetic stimulation pulse over the motor cortex, offer contradictory results regarding the sensory-to-motor transfer of spatial information. Here, we combined the techniques of AI and tactile repetition suppression (the decreased neurophysiological response following double stimulation of the same vs. different fingers) to investigate whether topographic information is preserved in the sensory-to-motor transfer in humans. We developed a double AI paradigm to examine both spatial (same vs. different finger) and temporal (short vs. long delay) aspects of sensorimotor interactions. Two consecutive electrocutaneous stimuli (separated by either 30 or 125 ms) were delivered to either the same or different fingers on the left hand (i.e. index finger stimulated twice or middle finger stimulated before index finger). Information about which fingers were stimulated was reflected in the size of the motor responses in a time-constrained manner: CSE was modulated differently by same and different finger stimulation only when the two stimuli were separated by the short delay (P = 0.004). We demonstrate that the well-known response of the somatosensory cortices following repetitive stimulation is mirrored in the motor cortex and that CSE is modulated as a function of the temporal and spatial relationship between afferent stimuli.

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Tactile response adaptation to whisker stimulation in the lemniscal somatosensory pathway of rats

Cited by 18 publications

References 77 publications

Multiple timescales account for adaptive responses across sensory cortices

Multiple timescales account for adaptive responses across sensory cortices

GABAergic and cholinergic modulation of repetition suppression in inferior temporal cortex

Somatotopy and temporal dynamics of sensorimotor interactions: evidence from double afferent inhibition

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