Tactile Sensitivity of Women with Turner Syndrome

Jajor, Julia; Kostiukow, Anna; Samborski, Włodzimierz; Rostkowska, Elżbieta; Śliwa, Aleksandra; Antosiak-Cyrak, Katarzyna

doi:10.3390/ijerph16203870

Cited by 3 publications

(3 citation statements)

References 13 publications

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“…Alterations in the frontal cortex and amygdala may be associated with the high prevalence of anxiety (McCauley et al, 1987 ; Schmidt et al, 2006 ) and social dysfunction in this population (Hong et al, 2011 ; Lepage, Dunkin, et al, 2013 ; McCauley et al, 1987 ; Romans et al, 1998 ). Parietal and postcentral alterations, in turn, may be related to TS‐associated deficits in visuospatial and sensory processing, respectively (Jajor et al, 2019 ; McCauley et al, 1987 ; Murphy et al, 1994 ). Concerning longitudinal differences, our finding of a slower rate of decline in cortical gray matter over time in TS is consistent with that of previous work by Lepage, Dunkin, et al ( 2013 ), Lepage, Hong, et al ( 2013 ), and Lepage, Mazaika, et al ( 2013 ) and, more recently, Li et al ( 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Adolescent brain development in girls with Turner syndrome

Wun

Foland‐Ross

et al. 2023

Human Brain Mapping

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Turner syndrome (TS) is a common sex chromosome aneuploidy in females associated with various physical, cognitive, and socio‐emotional phenotypes. However, few studies have examined TS‐associated alterations in the development of cortical gray matter volume and the two components that comprise this measure—surface area and thickness. Moreover, the longitudinal direct (i.e., genetic) and indirect (i.e., hormonal) effects of X‐monosomy on the brain are unclear. Brain structure was assessed in 61 girls with TS (11.3 ± 2.8 years) and 55 typically developing girls (10.8 ± 2.3 years) for up to 4 timepoints. Surface‐based analyses of cortical gray matter volume, thickness, and surface area were conducted to examine the direct effects of X‐monosomy present before pubertal onset and indirect hormonal effects of estrogen deficiency/X‐monosomy emerging after pubertal onset. Longitudinal analyses revealed that, whereas typically developing girls exhibited normative declines in gray matter structure during adolescence, this pattern was reduced or inverted in TS. Further, girls with TS demonstrated smaller total surface area and larger average cortical thickness overall. Regionally, the TS group exhibited decreased volume and surface area in the pericalcarine, postcentral, and parietal regions relative to typically developing girls, as well as larger volume in the caudate, amygdala, and temporal lobe regions and increased thickness in parietal and temporal regions. Surface area alterations were predominant by age 8, while maturational differences in thickness emerged by age 10 or later. Taken together, these results suggest the involvement of both direct and indirect effects of X‐chromosome haploinsufficiency on brain development in TS.

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Section: Discussionmentioning

confidence: 99%

Adolescent brain development in girls with Turner syndrome

Wun

Foland‐Ross

et al. 2023

Human Brain Mapping

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“…One possible explanation for the absence of any changes in VPTs could be that diverging factors canceled each other out. In theory, thicker skin increases the travel distance to the receptor, decreasing sensitivity (Jajor et al, 2019 ). On the other hand, increased skin hardness may decrease damping capabilities, so that vibrations travel further.…”

Section: Discussionmentioning

confidence: 99%

Does plantar skin abrasion affect cutaneous mechanosensation?

Wynands

Zippenfennig

Holowka

et al. 2022

Physiological Reports

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In humans, plantar cutaneous mechanoreceptors provide critical input signals for postural control during walking and running. Because these receptors are located within the dermis, the mechanical properties of the overlying epidermis likely affect the transmission of external stimuli. Epidermal layers are highly adaptable and can form hard and thick protective calluses, but their effects on plantar sensitivity are currently disputed. Some research has shown no effect of epidermal properties on sensitivity to vibrations, whereas other research suggests that vibration and touch sensitivity diminishes with a thicker and harder epidermis. To address this conflict, we conducted an intervention study where 26 participants underwent a callus abrasion while an age‐matched control group ( n = 16) received no treatment. Skin hardness and thickness as well as vibration perception thresholds and touch sensitivity thresholds were collected before and after the intervention. The Callus abrasion significantly decreased skin properties. The intervention group exhibited no change in vibration sensitivity but had significantly better touch sensitivity. We argue that touch sensitivity was impeded by calluses because hard skin disperses the monofilament's standardized pressure used to stimulate the mechanoreceptors over a larger area, decreasing indentation depth and therefore stimulus intensity. However, vibration sensitivity was unaffected because the vibrating probe was adjusted to reach specific indentation depths, and thus stimulus intensity was not affected by skin properties. Since objects underfoot necessarily indent plantar skin during weight‐bearing, calluses should not affect mechanosensation during standing, walking, or running.

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“…17 The proposed haptic testing suggests that a poorer tactile perception is still associated with a good performance of haptic recognition using visual recognition of 3D objects as a parameter (Table 3), which supports the possibility that haptic examination is a promising method to be applied to AD diagnosis and outcome of dementia. Touch thresholds decline with aging, 31 as well as spatial acuity, 32 due to peripheral neurological diseases 33 and other causes including rheumatologic diseases. This suggests a paradox in that aging causes the deterioration of the tactile sensitivity threshold but, nonetheless, maintains a relative preservation of haptic memory.…”

Section: Discussionmentioning

confidence: 99%

Applicability of tactile memory examination as an option to visual- and verbal-based batteries

Arambula¹,

Padovani²,

Corrente³

et al. 2021

Dement. neuropsychol.

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The validity and applicability of tactile battery tests for the diagnosis and medical follow-up of patients with Alzheimer’s disease and other dementia syndromes do not have their usefulness well understood in clinical practice. While haptic abilities in older individuals receive less attention, in earlier stages of human life they are well focused on. There are even fewer studies on tactile memory, including episodic memory of demented individuals with or without sensorial limitations. The applicability of a new haptic memory battery was evaluated in patients with Alzheimer’s disease with mild or moderate commitment. Objective: The aim of this study is to apply a battery based on tactile perception, recognition, and recollection of everyday objects in patients with Alzheimer’s disease, testing tactile delayed recall memory discrimination and late recognition to compare validated visual and verbal tests. Methods: Tactile-, visual-, and verbal-based memory performance was registered in 21 patients diagnosed with Alzheimer’s disease. Results: Except for tactile identification, it showed that there was a close relationship between the three sensory modalities of memory, with an apparent better performance of tactile incidental memory and recognition compared with the test with pictures. Conclusions: The haptic evaluation of memory demonstrated applicability in the evaluation of memory dysfunction in patients with Alzheimer’s disease. Further studies are needed to establish the sensibility and specificity of the proposed test that had a small sample size and many limitations.

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Tactile Sensitivity of Women with Turner Syndrome

Cited by 3 publications

References 13 publications

Adolescent brain development in girls with Turner syndrome

Adolescent brain development in girls with Turner syndrome

Does plantar skin abrasion affect cutaneous mechanosensation?

Applicability of tactile memory examination as an option to visual- and verbal-based batteries

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