Tactile stimulation and neonatal isolation affect behavior and oxidative status linked to cocaine administration in young rats

Antoniazzi, Caren Tatiane de David; Boufleur, Nardeli; Pase, Camila Simonetti; Kuhn, Fábio Teixeira; Dias, Verônica Tironi; Segat, Hecson Jesser; Roversi, Karine; Roversi, Katiane; Benvegnú, Dalila Moter; Bürger, Marilise Escobar

doi:10.1016/j.beproc.2014.01.011

Cited by 17 publications

(18 citation statements)

References 77 publications

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“…In opposition, when decreased, these behaviors are indicators of fear and anxiety, resulting in an increased anxiety index, as previously described (Hlavacona et al, 2010). Indeed, the beneficial influences of TS on anxiety parameters, as observed in the current study, are not innovative findings since previous studies by our group evidenced similar behaviors in rats exposed to neonatal TS (Antoniazzi et al, 2014a,b; Boufleur et al, 2013), consistently reinforcing the anxiolytic properties of this neonatal handling. Neonatal TS has an antidepressant‐like activity per se, also facilitating the activity of SERT, and this drug apparently contributes with lower TS‐induced anxiety and emotionality, since (i) time spent, number of entries and frequency of head dipping in the open arms of EPM were significantly higher in TS group treated with SERT, indicating a favorable interactive modulation between drug and neonatal handling; (ii) decreased hormone secretion from HPA axis following SERT administration in TS‐exposed group was also indicative of lower emotionality and stress; (iii) TS per se decreased plasma corticosterone levels, confirming beneficial influence of this neonatal handling on neuroendocrine function.…”

Section: Discussionsupporting

confidence: 75%

“…Tactile stimulation (TS) consisted of gently stimulating pups' dorsal surface individually with the index finger from rostral to caudal direction for 10 min (each day) out of the nest by the same experimenter (Antoniazzi et al, 2014a,b; Boufleur et al, 2012; 2013; Rodrigues et al, 2004). TS was applied daily between 12:00 and 14:00 from PND8 until PND14, according to previous studies by our group (data submitted), since most beneficial influence of TS has been observed in pups.…”

Section: Methodsmentioning

confidence: 99%

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Neonatal tactile stimulation decreases depression‐like and anxiety‐like behaviors and potentiates sertraline action in young rats

Freitas¹,

Antoniazzi

Segat³

et al. 2015

Intl J of Devlp Neuroscience

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It is well known that events which occur in early life exert a significant influence on brain development, what can be reflected throughout adulthood. This study was carried out in order to assess the influence of neonatal tactile stimulation (TS) on behavioral and morphological responses related to depression-like and anxiety-like behaviors, assessed following the administration of sertraline (SERT), a selective serotonin re-uptake inhibitor (SSRI). Male pups were submitted to daily TS, from postnatal day 8 (PND8) to postnatal day 14 (PND14), for 10 min every day. On PND50, adult animals were submitted to forced swimming training (15 min). On PND51, half of each experimental group (UH and TS) received a single sub-therapeutic dose of sertraline (SER, 0.3mg/kg body weight, i.p.) or its vehicle (C, control group). Thirty minutes after injection, depression-like behaviors were quantified in forced swimming test (FST, for 5 min). On the following day, anxiety-like behaviors were assessed in elevated plus maze (EPM), followed by biochemical assessments. TS per se increased swimming time, decreasing immobility time in FST. Besides, TS per se was able to increase frequency of head dipping and time spent in the open arms of EPM, resulting in decreased anxiety index. In addition, groups exposed to TS showed decreased plasma levels of corticosterone per se. Interestingly, while TS exposure significantly potentiated the antidepressant activity of a subtherapeutic dose of SERT, this drug was able to exacerbate TS-induced anxiolytic activity, as observed in FST and EPM, respectively. Decreased plasma levels of both corticosterone and cortisol in animals exposed to TS and treated with SERT are able to confirm the interesting interaction between this neonatal handling and the antidepressant drug. From our results, we conclude that neonatal TS is able to exert beneficial influence on the ability to cope with stressful situations in adulthood, preventing depression and favorably modulating the action of antidepressant drugs.

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Section: Discussionsupporting

confidence: 75%

Section: Methodsmentioning

confidence: 99%

Neonatal tactile stimulation decreases depression‐like and anxiety‐like behaviors and potentiates sertraline action in young rats

Freitas¹,

Antoniazzi

Segat³

et al. 2015

Intl J of Devlp Neuroscience

Self Cite

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“…Several studies have demonstrated that TS is a model of positive early experiences in developing rats (Richards et al, ; Antoniazzi et al, ; Horiquini‐Barbosa and Lachat, ), exerting a solid influence on brain development (Chiba et al, ). In this regard, our current findings indicate that animals exposed to TS during the second week of life (PND8‐14) showed reduced anxiety‐like behavior, as observed by: (i) increased time spent in open arms of EPM, resulting in a lower anxiety index (AI) in this same paradigm; and (ii) reduction of their cumulative burying time in DBT, which is a type of strategy associated with the active behavior of burying shock probe (Matuszewich et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…TS consisted of the same experimenter gently stimulating the pups' dorsal surface individually with the index finger from rostral to caudal direction for 10 min (each day) out of the nest (Boufleur et al, ; Antoniazzi et al, ). TS was applied daily between 12:00 and 14:00 according to the period of each experimental group.…”

Section: Methodsmentioning

confidence: 99%

“…Previous studies performed by our group have demonstrated that 21 days of TS were sufficient to prevent cocaine and amphetamine conditioned place preference (CPP; Antoniazzi et al, , 2014b), also reducing anxiety‐like behavior after chronic mild stress (Boufleur et al, ) and improving responsiveness of rodents to benzodiazepine drugs (Boufleur et al, ). Currently the literature reports only studies involving animals exposed to TS throughout the postnatal period, that is, from the first days after birth until weaning.…”

Section: Introductionmentioning

confidence: 99%

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Tactile stimulation during different developmental periods modifies hippocampal BDNF and GR, affecting memory and behavior in adult rats

et al. 2016

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Recent studies have shown that tactile stimulation (TS) in pups is able to prevent and/or minimize fear, anxiety behaviors, and addiction to psychostimulant drugs in adult rats. In these studies, animals have been exposed to handling from postnatal day (PND) 1-21. This study was designed to precisely establish which period of preweaning development has a greater influence of TS on neuronal development. After birth, male pups were exposed to TS from PND1-7, PND8-14, and PND15-21. In adulthood, the different periods of postnatal TS were assessed through behavioral, biochemical, and molecular assessments. Animals that received TS from PND8-14 showed lower anxiety-like symptoms, as observed by decreased anxiety index in elevated plus maze. This same TS period was able to improve rats' working memory by increasing the percentage of alternation rate in Y-maze, and induce better ability to cope with stressful situations, as showed in the defensive burying test by a reduced time of burying behavior. On the other hand, animals receiving TS in the first week of life showed longest cumulative burying time, which is directly related to increased anxiety-like behavior. Moreover, TS from PND8-14 showed lower corticosterone levels and better oxidative status, as observed by decreased lipid peroxidation and increased catalase activity in the hippocampus. Brain-derived neurotrophic factor (BDNF) immunocontent was increased in the hippocampus of animals receiving TS from PND8-14, while glucocorticoid receptors immunocontent was decreased in both TS and TS , but not TS . To the best of our knowledge, this study is the first to show TS can be more efficient if applied over a focused period of neonatal development (PND8-14) and this beneficial influence can be reflected on reduced emotionality and increased ability to address stressful situations in adulthood. © 2016 Wiley Periodicals, Inc.

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Tactile Stimulation on Adulthood Modifies the HPA Axis, Neurotrophic Factors, and GFAP Signaling Reverting Depression-Like Behavior in Female Rats

et al. 2019

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Tactile stimulation and neonatal isolation affect behavior and oxidative status linked to cocaine administration in young rats

Cited by 17 publications

References 77 publications

Neonatal tactile stimulation decreases depression‐like and anxiety‐like behaviors and potentiates sertraline action in young rats

Neonatal tactile stimulation decreases depression‐like and anxiety‐like behaviors and potentiates sertraline action in young rats

Tactile stimulation during different developmental periods modifies hippocampal BDNF and GR, affecting memory and behavior in adult rats

Tactile Stimulation on Adulthood Modifies the HPA Axis, Neurotrophic Factors, and GFAP Signaling Reverting Depression-Like Behavior in Female Rats

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