Tactile stimulation facilitates functional recovery and dendritic change following neonatal hemidecortication in rats

Day, Morgan; Gibb, Robbin; Kolb, Bryan

doi:10.1016/j.bbr.2023.114582

Cited by 2 publications

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

The effect of tactile stimulation on spatial memory and hippocampal neuronal density in male rats with sensory deprivation during a critical period

Ozkan,

Oz,

Erdogan

et al. 2024

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

It is well known that sensory information driven from whiskers serves as an example of tactile perception in rodents, and plays an important role in social behavior, environmental exploration, and decision‐making processes, the influence of manipulations performed during the development of whiskers, on learning has been received little attention in the literature. This study aimed to evaluate the effect of tactile stimulation (TS) on spatial memory performance and neuronal density in the hippocampus during adulthood in early sensory‐deprived rats. Wistar albino male rats were divided into four groups: control (CTL), bilateral whisker trimming (BWT), tactile stimulation (TS), and bilateral whisker trimming+tactile stimulation (BWT + TS). All whiskers were trimmed between P0–10, a critical period for whisker development. TS was applied from P3 to P21 using a soft brush. In this study, the 8‐arm radial maze test was conducted from postnatal days 77 to 81 to assess spatial memory Animals sacrificed by intracardial perfusion and neuronal density in CA1, CA3, vDG, and dDG regions of the hippocampus were evaluated by Nissl staining. TS exposure negatively affected spatial memory performance and hippocampal neuronal density compared to BWT. We conclude that TS in healthy offspring can cause stress by interrupting maternal care, given the vulnerability of early development. On the contrary, the sensory deprivation protocol in this study was terminated at a time of high homeostatic plasticity and did not produce complete whisker deprivation, have triggered learning by inducing moderate stress early in development.

show abstract

The effect of tactile stimulation on spatial memory and hippocampal neuronal density in male rats with sensory deprivation during a critical period

Ozkan,

Oz,

Erdogan

et al. 2024

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

show abstract

Behavioral and anatomical effects of complex rearing after day 7 neonatal frontal lesions vary with sex

Gibb,

Kolb

2024

Preprint

Self Cite

View full text Add to dashboard Cite

Rats received medial frontal lesions, or sham surgery, on postnatal day 7 (P7), and were placed in complex environments or standard lab housing at weaning. Three months later the animals were tested in a spatial learning task and in a skilled reaching task. Rats with P7 lesions had smaller deficits in spatial learning than similar adult operates, and males performed better than females. Complex housing further improved the performance of male, but not female, lesion rats. The opposite was seen in motor performance as female lesion rats performed better than males and benefited from experience whereas males did not. There was a correlation between behavior and dendritic change as complex housing reversed lesion-induced dendritic atrophy, an effect that was greater in males. P7 frontal males, but not females, showed an increase in spine density that was reversed by complex housing. Experience thus can affect functional and anatomical outcome after early brain injury, but the effects vary with sex.

show abstract

Tactile stimulation facilitates functional recovery and dendritic change following neonatal hemidecortication in rats

Cited by 2 publications

References 59 publications

The effect of tactile stimulation on spatial memory and hippocampal neuronal density in male rats with sensory deprivation during a critical period

The effect of tactile stimulation on spatial memory and hippocampal neuronal density in male rats with sensory deprivation during a critical period

Behavioral and anatomical effects of complex rearing after day 7 neonatal frontal lesions vary with sex

Contact Info

Product

Resources

About