Tadalafil against hyperoxia‐induced oxidative stress; an experimental study

Yeni, Sezgin; Demir, Aslan; Kilicarslan, Nermin; Çiçek, Mehmet Çağatay; Saricetin, Aysun; Dirican, Melahat; Ertan, E.

doi:10.1111/and.14494

Cited by 2 publications

(9 citation statements)

References 23 publications

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“…Normally, the body's defense and protection system aims to protect the integrity of the cell for normal function of the cell by activating the antioxidant mechanism against ROS up to a certain threshold. Therefore, the cell tries to deal with the OS in this way [ 1 ]. Once this threshold point is exceeded in favor of ROS, the cell needs exogenous antioxidants to maintain its integrity and thus function, and this suggests that the balance between SOD and ROS is achieved by some kind of feedback mechanism [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

“…Many patients have been exposed to oxygen therapy due to their decreased saturation depending on lung involvement because of some diseases, such as chronic obstructive pulmonary disease, cancer, some respiratory disorders in newborns, and some infectious diseases, especially, currently COVID-19 [ 1 , 2 ]. Continuous oxygen therapy to compensate for decreased oxygen saturation in the blood is a life-saving treatment commonly used in critically ill patients [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…All living aerobic cells are normally exposed to some ROS that is toxic to living organisms [ 9 , 10 ]. In fact, the body tries to eliminate the harmful effects of ROS with its antioxidant defense systems such as superoxide dismutase (SOD) and catalase that interact with them and protect the organism against these metabolites [ 1 , 11 , 12 ]. As a result of normal living conditions, the living organism manages to survive in a healthy way with a delicate balance between the positive and negative effects of ROS products to which it is constantly exposed [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…As a result of normal living conditions, the living organism manages to survive in a healthy way with a delicate balance between the positive and negative effects of ROS products to which it is constantly exposed [ 13 ]. The antioxidant defense mechanism achieves these processes endogenously in an enzymatic way (such as SOD, glutathione peroxidase (GPx), catalase (CAT) and exogenously in a non-enzymatic way [ascorbic acid (Vitamin C), -tocopherol (Vitamin E), glutathione (GSH), carotenoids, flavonoids, and other antioxidants] [ 1 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…In the literature, it is possible to find many studies using tadalafil as an exogenous antioxidant to reduce various organ damage due to ROS. However, these studies differ from each other in terms of their results [ 1 , 15 – 18 ]. With this study model, we investigated the effects of hyperoxia on the rat kidneys and whether tadalafil has an effect to reduce this damage, to shed some light on this issue.…”

Section: Introductionmentioning

confidence: 99%

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The danger of hyperoxia on the rat kidneys: is tadalafil a real shield?

et al. 2022

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Purpose Continuous oxygen therapy to compensate for decreased oxygen saturation in the blood is a life-saving treatment used in case lung involvement. Excess oxygen delivery was reported to be a common situation, in which about 50% of the patients showed hyperoxemia and 4% in severe hyperoxemia. In this work, we investigated the effects of hyperoxia on the rat kidneys and whether tadalafil has an effect to reduce this damage. Materials and methods Three groups of 8 male rats each weighing 300–350 g were formed. The groups were divided into the control group, hyperoxia group, and hyperoxia and tadalafil administered group for 10 days. At the end of the 10th day, blood and kidney samples were taken for biochemical analysis (SOD and NO levels) and histopathological examination. Results While our findings showed that SOD levels were significantly different among the control and experimental groups and within the experimental groups, no statistical difference was found in terms of NO levels among the groups (Table 1). While the glomerular and tubular injury was higher in the Hyperoxia group and the Hyperoxia + Tadalafil group than in the control group ( p < 0.001), as a result of the rate of severe glomerular and tubular injury in the hyperoxia group, was 62.5% and 43.8% and in the group given tadalafil was 43.8% and 31.3%, respectively (Table 2). Conclusions Exposure to hyperoxia condition causes renal glomerular and tubular damage, and tadalafil does not show a protective effect on this damage according to this study’s dose and exposure time.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The danger of hyperoxia on the rat kidneys: is tadalafil a real shield?

et al. 2022

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Changes in Left Ventricular Ejection Fraction and Oxidative Stress after Phosphodiesterase Type-5 Inhibitor Treatment in an Experimental Model of Retrograde Rat Perfusion

Krivokapic

Omarov²,

Živković

et al. 2023

Medicina

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Background and objectives: Taking into consideration the confirmed role of oxidative stress in ischemia/reperfusion injury and the insufficiency in knowledge regarding the phosphodiesterase 5 (PDE5)-mediated effects on the cardiovascular system, the aim of our study was to investigate the influence of two PDE5 inhibitors, tadalafil and vardenafil, with or without the addition of N(G)-nitro-L-arginine methyl ester (L-NAME), on oxidative stress markers, coronary flow and left ventricular function, both ex vivo and in vivo. Methods: This study included 74 male Wistar albino rats divided into two groups. In the first, 24 male Wistar rats were orally treated with tadalafil or vardenafil for four weeks in order to perform in vivo experiments. In the second, the hearts of 50 male Wistar albino were excised and perfused according to the Langendorff technique in order to perform ex vivo experiments. The hearts were perfused with tadalafil (10, 20, 50 and 200 nM), vardenafil (10, 20, 50 and 200 nM) and a combination of tadalafil/vardenafil and L-NAME (30 μM). The CF and oxidative stress markers, including nitrite bioaviability (NO2−), superoxide anion radical (O2−), and the index of lipid peroxidation, were measured in coronary effluent. Results: The L-arginin/NO system acts as the mediator in the tadalafil-induced effects on the cardiovascular system, while it seems that the vardenafil-induced increase in CF was not primarily induced by the NO system. Although tadalafil induced an increase in O2− in the two lowest doses, the general effects of both of the applied PDE5 inhibitors on oxidative stress were not significant. The ejection function was above 50% in both groups. Conclusions: Our results showed that both tadalafil and vardenafil improved the coronary perfusion of the myocardium and LV function by increasing the EF.

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Tadalafil against hyperoxia‐induced oxidative stress; an experimental study

Cited by 2 publications

References 23 publications

The danger of hyperoxia on the rat kidneys: is tadalafil a real shield?

The danger of hyperoxia on the rat kidneys: is tadalafil a real shield?

Changes in Left Ventricular Ejection Fraction and Oxidative Stress after Phosphodiesterase Type-5 Inhibitor Treatment in an Experimental Model of Retrograde Rat Perfusion

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