Tadalafil enhances working memory, and reduces hippocampal oxidative stress in both young and aged mice

Al-Amin, Md.; Hasan, S.M. Nageeb; Alam, Tanzir; Hasan, Ahmed Tasdid; Hossain, Imran; Didar, Rohini Rowshan; Alam, Md. Ashraful; Rahman, Mahbubur

doi:10.1016/j.ejphar.2014.10.026

Cited by 39 publications

(34 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Administration of selective PDE inhibitors elevates cyclic nucleotide concentrations, which might trigger transcription of genes that facilitate the formation of long‐term memories . Tadalafil crosses the blood–brain barrier, and has been shown to enhance working memory and reduce hippocampal oxidative stress in both young and aged mice . In the present study, tadalafil improved cognitive function in the novel object recognition test.…”

Section: Discussionsupporting

confidence: 48%

“…In a rat model of chronic bladder ischemia, long‐term treatment with tadalafil was shown to protect bladder function and prevent fibrosis, resulting in amelioration of bladder hyperactivity . Interestingly, tadalafil also enhances working memory, and reduces hippocampal oxidative stress in both young and aged mice . It is speculated that lower abdominal pain or discomfort caused by PC induces the depressed state, and cognitive function, such as memory, thinking, understanding, calculation, learning, language and judgment, might be deteriorated.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Tadalafil improves bladder dysfunction and object recognition in rats with pelvic venous congestion

Nishijima¹,

Sugaya²,

Kadekawa³

et al. 2019

Int J of Urology

View full text Add to dashboard Cite

Objectives To examine the effects of tadalafil on bladder function and object recognition ability in rats with alterations in urinary frequency and locomotor activity as a result of pelvic venous congestion. Methods A total of 48 female rats were divided into three groups (sham, pelvic venous congestion and pelvic venous congestion/tadalafil groups). In the pelvic venous congestion and pelvic venous congestion/tadalafil groups, the bilateral common iliac veins and uterine veins were ligated under anesthesia. Rats in the pelvic venous congestion/tadalafil group received a diet containing tadalafil, and the other rats were fed a normal diet. After 4 weeks, rats underwent analysis of voiding behavior, locomotor activity, a novel object recognition test, continuous cystometry, measurement of plasma monoamines, and measurement of plasma and urinary nitric oxide metabolites. Expression of nitric oxide synthase messenger ribonucleic acid in the bladder wall was also assessed, along with histological examination of the bladder. Results Rats with pelvic venous congestion showed a higher urinary frequency, lower locomotor activity, and lower plasma and urinary nitric oxide levels than sham rats. The bladder wall endothelial nitric oxide synthase messenger ribonucleic acid level was low and object recognition was impaired. Pelvic venous congestion/tadalafil rats showed improvement in locomotor activity, bladder function and object recognition compared with pelvic venous congestion rats, as well as elevation of plasma and urinary nitric oxide, plasma monoamines, and bladder neuronal nitric oxide synthase messenger ribonucleic acid expression. Bladder wall vascularity was greater in pelvic venous congestion/tadalafil rats compared with sham rats. Conclusions In rats with pelvic venous congestion, tadalafil might improve bladder function and the general condition by increasing blood flow to the bladder and brain, and by increasing dopamine levels.

show abstract

Section: Discussionsupporting

confidence: 48%

Section: Introductionmentioning

confidence: 99%

Tadalafil improves bladder dysfunction and object recognition in rats with pelvic venous congestion

Nishijima¹,

Sugaya²,

Kadekawa³

et al. 2019

Int J of Urology

View full text Add to dashboard Cite

show abstract

“…Moreover, NO levels in aged and young mice were decreased by chronic tadalafil treatment, another PDE-5 inhibitor, and by ameliorating lipid peroxidation levels a beneficial effect in neuroprotection was also reported. Similarly, we observed an increase in NO and MDA levels of stressed rats and a decline in NO levels and MDA levels of stressed sedentary rats with chronic sildenafil application [69].…”

Section: Discussionmentioning

confidence: 87%

Protective effect of exercise and sildenafil on acute stress and cognitive function

Özbeyli¹,

Gokalp²,

Koral³

et al. 2015

Physiology & Behavior

View full text Add to dashboard Cite

“…Some studies have been performed that indicate that PDE5 inhibitors have beneficial effects on oxidative stress. Al-Amin et al 66 reported that tadalafil decreased the levels of MDA and NO in young and old rats. Fan et al 67 reported that vardenafil treatment did not change the MDA level but increased superoxide dismutase (SOD) activity in patients with pulmonary arterial hypertension.…”

Section: Discussionmentioning

confidence: 99%

The effect of PDE5 inhibitors on bone and oxidative damage in ovariectomy-induced osteoporosis

Hakan

Huyut

Yıldırım

et al. 2017

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

The results in our study appear to establish the osteoporosis model and provide evidence of the positive effects of three separate PDE5 inhibitors (vardenafil, udenafil, and tadalafil). The positive effects of these PDE5 inhibitors are investigated and demonstrated by the bone mass density and bone resorption markers. These effects are associated with significant demonstrated antioxidant activities. Osteoporosis is a significant major public health problem especially in more aged populations. Advances in identifying and understanding new potential therapeutic modalities for this disease are significant. This study provides such an advance. AbstractOsteoporosis is a major public health problem associated with many factors, and it affects more than 50% of women over 50 years old. In the current study, our purpose was to investigate the effects of phosphodiestarase-5 inhibitors on osteoporosis via the nitric oxide/3 0 ,5 0 -cyclic guanosine monophosphate/protein kinase G signalling pathway. A total of 50 female albino Wistar rats were separated into five groups. The first group was appointed as the healthy control group with no ovariectomy. All animals in the other groups underwent a bilateral ovariectomy. Six months after the ovariectomy, vardenafil, udenafil and tadalafil were given to the third, fourth and fifth groups, respectively, but were not administered to the positive control group (10 mg/kg per day for two months). The bone mineral density values were determined using a densitometry apparatus for all groups pre-and post-ovariectomy as well as after treatment. The levels of nitric oxide, endothelial nitric oxidesynthase, asymmetric dimethylarginine, 3 0 ,5 0 -cyclic guanosine monophosphate, protein kinase G, phosphodiestarase-5, pyridinoline, deoxypyridinoline, carboxyterminal telopeptide fragments and plasma carboxy terminal propeptide of type I collagen were determined using an enzyme linked immunosorbent assay. The levels of malondialdehyde, 8-hydroxy-2-deoxy guanosine, deoxyguanosine and coenzyme Q10 were determined by a high-performance liquid chromatography assay. Additionally, the right femoral trabecular bone density and the epiphyseal plate were measured in all groups. Angiogenesis was histologically observed in the bone tissue. In addition, we determined that the inhibitors may have caused a positive impact on the increased bone mass density and reduction of bone resorption markers. We also observed the positive effects of these inhibitors on oxidative stress. In conclusion, these phosphodiestarase-5 inhibitors increase angiogenesis in bone tissue and improve the re-formation rate of bone in rats with osteoporosis.

show abstract

Tadalafil enhances working memory, and reduces hippocampal oxidative stress in both young and aged mice

Cited by 39 publications

References 41 publications

Tadalafil improves bladder dysfunction and object recognition in rats with pelvic venous congestion

Tadalafil improves bladder dysfunction and object recognition in rats with pelvic venous congestion

Protective effect of exercise and sildenafil on acute stress and cognitive function

The effect of PDE5 inhibitors on bone and oxidative damage in ovariectomy-induced osteoporosis

Contact Info

Product

Resources

About