Taenia taeniaeformis: Fate and proliferation of mucosal cells during gastric hyperplasia in larvae infected rats

Lagapa, Jose Trinipil; Oku, Yuzaburo; Nonaka, Nariaki; Kamiya, Mitsunobu

doi:10.1016/j.exppara.2007.12.004

Cited by 6 publications

(2 citation statements)

References 19 publications

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“…Infected rats may develop lesions of inhibited gastric acid secretion, hypergastrinemia, and gastric and intestinal mucosal hyperplasia [18,26]. These changes are attributed to larval secretions in the gastric and intestinal lumen [21].…”

Section: Discussionmentioning

confidence: 99%

Strobilocercus fasciolaris induced hepatic sarcoma in Wistar Rats

Kumar,

Sudan

2024

Preprint

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Background Taenia taeniaeformis infects the small intestine of domestic and wild carnivores. Rodents, the intermediate hosts, ingest the gravid proglottids from the carnivores' feces. The parasite’s oncosphere reaches the liver via portal circulation after penetrating the wall of small intestine. Purpose The present study reports hepatic sarcoma caused by strobilocercus- the metacestodal stage of Taenia taeniformis in laboratory rats. Method Twenty-three rats in a colony of 72 male wistar rats died suddenly with clinical signs of weakness, lethargy and mild diarrhea. The carcasses were sent to the department of veterinary pathology for postmortem examination. Results Grossly, the liver of 18 rats were having multiple, cream to white cysts of variable sizes of Strobilocercus fasciolaris. Histopathologically, the hepatic tissue surrounding the cysts revealed zones of fatty change, inflammation with infiltration of plasma cells, macrophages and eosinophils, presence of granulation tissue, metaplasia and fibrosarcoma. The pathological changes in the stomach and small intestines include hyperplasia of gastric and intestinal glands and their mucosa. Conclusion The likelihood of altered research results of studies conducted in immune-compromised T. taeniformisinfected rats and its zoonotic implications are discussed herewith.

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Section: Discussionmentioning

confidence: 99%

Strobilocercus fasciolaris induced hepatic sarcoma in Wistar Rats

Kumar,

Sudan

2024

Preprint

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“…Hanby et al (1999) haviam proposto que as células mucosas do colo constituem uma linhagem celular distinta, importante e funcional, e não um estado transitório na via de diferenciação de células zimogênicas, e essa idéia foi apoiada por outros pesquisadores (Dixon, 2001;Morgenstern et al, 2001). Entretanto, a teoria de origem das células zimogênicas a partir de células mucosas do colo é bem aceita e tem sido confirmada por outros estudos (Judd et al, 1999;Ramsey et al, 2007;Lagapa et al, 2008). Ramsey et al (2007) mostraram que a deleção do gene Mist1 aumenta o número de células mucosas do colo e sugeriram que essa resposta resulta de uma diminuição na transição de células mucosas do colo para células zimogênicas.…”

Section: Estômagounclassified

O papel do alimento, do fator de crescimento transformante alfa e do receptor do fator de crescimento epidermal na proliferação e diferenciação celular durante o desenvolvimento pós-natal do epitélio gástrico de ratos.

Osaki¹

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Osaki LH. The role of transforming growth factor alpha and epidermal growth factor receptor in the proliferation and differentiation of the gastric epithelium of developing rats [PhD Thesis]. São Paulo: Instituto de Ciências Biomédicas da Universidade de São Paulo; 2009.The abrupt interruption of suckling at early weaning (EW) causes changes in the gastric mucosa, such as increased cell proliferation and Transforming Growth Factor α (TGFα) expression. We evaluated the role of this peptide and its receptor EGFR in the control of gastric growth. 15-d-old Wistar rats were splitted into two groups: suckling (control) and EW, in which pups were separated from the dam and fed with powdered chow. Early weaning increased the number of immunolabeled cells for EGFR, which is mainly expressed in surface mucous and parietal cells. The mucous neck cells differentiation was studied by PAS-AB or BSII lectin reactions, which showed a significant increase in this cell population beginning at 17 days. We also observed increased mucin 6 mRNA expression. After EGFR inhibition with AG1478, we investigated the cell proliferation by calculating the DNA synthesis (SI) and mitotic (MI) indexes, and we found a reduction in both of them, followed by decreased number of mucous neck cells. Proteins involved in EGFR signaling pathways and cell cycle were studied by Western Blot. Early weaning induced p-ERK1/2 and p-Src increased levels at 17 days and did not change Akt, p21 and p27. We suggest that the diet pattern influences the proliferation and differentiation in gastric epithelium, and that TGFα/EGFR can regulate these processes throughout the postnatal development, probably by activating MAPK and Src signaling pathways.

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