TAFRO syndrome et vascularite nécrosante cutanée : une association inédite

Maquet, Julien; Bories, E.; Beck, Conrad; Aizel, G.; Faguer, Stanislas; Nogier, Marie-Béatrice; Paricaud, K.; Pugnet, G.; Moulis, Guillaume; Astudillo, L.; Sailler, L.

doi:10.1016/j.revmed.2019.10.248

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2023

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“…Hypothyroidism is a common pathology estimated at 3.1% [1]. TAFRO syndrome is rare, first described in 2010 in Japan, diagnosed as a particular form of multicentric Castleman's disease without proliferation of herpes virus type 8: HHV8, including thrombocytopenia, anasarca, fever, myelofibrosis, renal failure, and organomegaly [2]. Its correlation with hypothyroidism has been reported between elevated levels of vascular endothelial growth factor (VEGF) and TSH in patients with hypothyroidism.…”

Section: Introductionmentioning

confidence: 99%

Peripheral hypothyroidism and TAFRO syndrome: Particularity of management

M’BALLOU¹,

EZZAHRA²,

AHMED³

et al. 2023

World J. Adv. Res. Rev.

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TAFRO syndrome is defined by the presence of thrombocytopenia, hydrops, fever, fibrosis, renal dysfunction, and organomegaly and can be seen with idiopathic multicentric Castleman disease (iMCD) or as an isolated process without iMCD. The pathophysiology of TAFRO is not well understood, but it is thought to be related to hypercytokinemia. Subclinical hypothyroidism may be a potential factor in the pathogenesis and symptomatology of TAFRO syndrome with elevated vascular endothelial growth factor (VEGF).There are no clear guidelines for the treatment of TAFRO in the absence of a definitive diagnosis of iMCD, resulting in suboptimal management and high morbidity. We report a case of hypothyroidism revealed by TAFRO syndrome.

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Section: Introductionmentioning

confidence: 99%