Tai Chi Exercise for Cancer-Related Fatigue in Patients With Lung Cancer Undergoing Chemotherapy: A Randomized Controlled Trial

Zhang, Lili; Wang, Shuzhen; Chen, Honglin; Yuan, Ang

doi:10.1016/j.jpainsymman.2015.11.020

Cited by 81 publications

(121 citation statements)

References 31 publications

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“…The interventions in the control group, which included conventional therapy [41, 44], low-impact exercise [42], sham Qigong [43], relaxation exercises [45], stretching and wellness education [46], sleep seminars [47], no intervention [48, 50], and fast walking [49], could be regarded as conventional treatment or relaxation exercise. Tables 1 and 2 provide detailed information on the study characteristics.…”

Section: Resultsmentioning

confidence: 99%

“…Five studies [42, 45–48] reported the random method of using a computer-generated random sequence, while one study [50] used only a random number table to divide communities into experimental community and control community. Two studies [41, 49] lacked descriptions of the method of random sequence generation.…”

Section: Resultsmentioning

confidence: 99%

“…Eight studies [41, 42, 44, 46–50] lacked details on whether participants and administrators were blinded, however it was clear blinding had been broken due to obvious differences between intervention group and control group. Although one study [45] mentioned it was double-blind, we also determined the blind had been broken because of disparities between the two groups.…”

Section: Resultsmentioning

confidence: 99%

“…Although one study [45] mentioned it was double-blind, we also determined the blind had been broken because of disparities between the two groups. Six trials [41, 42, 44, 46, 49, 50] did not employ blinding of the outcome assessments, One study [42] said that it was impossible to blind the participants or data collector. After contacted authors, one study [44] replied to us that they didn’t blind to outcome assessors and data collectors.…”

Section: Resultsmentioning

confidence: 99%

“…Two studies [42, 49] had a high dropout rate and provided detailed explanations, but did not do specific statistical analysis. Three studies [43, 47, 50] reported low dropout rates within the range of statistical estimations provided in advance of the studies.…”

Section: Resultsmentioning

confidence: 99%

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Does Tai Chi relieve fatigue? A systematic review and meta-analysis of randomized controlled trials

Lu²,

Chen³

et al. 2017

PLoS ONE

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BackgroundFatigue is not only a familiar symptom in our daily lives, but also a common ailment that affects all of our bodily systems. Several randomized controlled trials (RCTs) have proven Tai Chi to be beneficial for patients suffering from fatigue, however conclusive evidence is still lacking. A systematic review and meta-analysis was performed on all RCTs reporting the effects of Tai Chi for fatigue.MethodsIn the end of April 2016, seven electronic databases were searched for RCTs involving Tai Chi for fatigue. The search terms mainly included Tai Chi, Tai-ji, Taiji, fatigue, tiredness, weary, weak, and the search was conducted without language restrictions. Methodological quality was assessed using the Cochrane Risk of Bias tool. RevMan 5.3 software was used for meta-analysis. Publication bias was estimated with a funnel plot and Egger’s test. We also assessed the quality of evidence with the GRADE system.ResultsTen trials (n = 689) were included, and there was a high risk of bias in the blinding. Two trials were determined to have had low methodological quality. Tai Chi was found to have improved fatigue more than conventional therapy (standardized mean difference (SMD): -0.45, 95% confidence interval (CI): -0.70, -0.20) overall, and have positive effects in cancer-related fatigue (SMD:-0.38, 95% CI: -0.65, -0.11). Tai Chi was also more effective on vitality (SMD: 0.63, 95% CI: 0.20, 1.07), sleep (SMD: -0.32, 95% CI: -0.61, -0.04) and depression (SMD: -0.58, 95% CI: -1.04, -0.11). However, no significant difference was found in multiple sclerosis-related fatigue (SMD: -0.77, 95% CI: -1.76, 0.22) and age-related fatigue (SMD: -0.77, 95% CI: -1.78, 0.24). No adverse events were reported among the included studies. The quality of evidence was moderate in the GRADE system.ConclusionsThe results suggest that Tai Chi could be an effective alternative and /or complementary approach to existing therapies for people with fatigue. However, the quality of the evidence was only moderate and may have the potential for bias. There is still absence of adverse events data to evaluate the safety of Tai Chi. Further multi-center RCTs with large sample sizes and high methodological quality, especially carefully blinded design, should be conducted in future research.Registration numberPROSPERO CRD42016033066

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Does Tai Chi relieve fatigue? A systematic review and meta-analysis of randomized controlled trials

Lu²,

Chen³

et al. 2017

PLoS ONE

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Exercise training for advanced lung cancer

Peddle-McIntyre

Singh

Thomas

et al. 2019

Cochrane Database of Systematic Reviews

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Cochrane Database of Systematic Reviews peripheral muscles, and we presented the results narratively. Limited data were available for level of physical activity, adverse events, performance status, body weight and overall survival. Main results We identified six RCTs, involving 221 participants. The mean age of participants ranged from 59 to 70 years; the sample size ranged from 20 to 111 participants. Overall, we found that the risk of bias in the included studies was high, and the quality of evidence for all outcomes was low. Study characteristics We looked for all research studies (randomised controlled trials) published up to July 2018. We found six studies which included 221 participants, with an average age ranging from 59 to 70 years. These studies included di erent numbers of people, ranging from 20 to 111. Key results Our results showed that, compared to those who did not exercise, people with lung cancer who did exercise were fitter and had a better quality of life. We did not find any di erence in muscle strength, shortness of breath, tiredness, feelings of anxiety and depression, or lung function. No serious harms were reported in people with lung cancer who exercised, but only three studies talked about harms. Quality of the evidence The results of this review are not clear, mainly because of the small number of studies found, the small numbers of people in those studies, and because the studies did not seem to have been carried out to a high standard.

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Tai Chi for cancer survivors: A systematic review toward consensus‐based guidelines

et al. 2021

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Tai Chi Exercise for Cancer-Related Fatigue in Patients With Lung Cancer Undergoing Chemotherapy: A Randomized Controlled Trial

Abstract: Tai Chi is an effective intervention for managing cancer-related fatigue in patients with lung cancer undergoing chemotherapy, especially for decreasing general fatigue and physical fatigue, and increasing vigor.

Cited by 81 publications

References 31 publications

Does Tai Chi relieve fatigue? A systematic review and meta-analysis of randomized controlled trials

Does Tai Chi relieve fatigue? A systematic review and meta-analysis of randomized controlled trials

Exercise training for advanced lung cancer

Tai Chi for cancer survivors: A systematic review toward consensus‐based guidelines

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