Tai Chi Intervention Increases Progenitor CD34<sup>+</sup> Cells in Young Adults

Ho, Tsung Jung; Ho, Ling‐Jun; Hsueh, Kuo Wei; Chan, Tzu Min; Huang, Shih Li; Lin, Jaung Geng; Liang, Wen Miin; Hsu, Wei Hung; Harn, Horng Jyh; Lin, Shinn Zong

doi:10.3727/096368914x678355

Cited by 8 publications

(14 citation statements)

References 45 publications

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“… 15 – 20 , 23 , 24 Recent data on the effects of biological effects of martial arts have also been described. To this end, Ho et al 27 reported an increase in blood CD34+ progenitor cells in those engaged in the practice of Tai Chi suggesting its value as an antiaging therapy, while Chyu et al 28 reported an increase in serum insulin growth factor 1 levels, facilitating promotion and maintenance of muscle mass and neuronal function in overweight/obese premenopausal women who participated in a martial arts exercise intervention. 29 , 30 …”

Section: Discussionmentioning

confidence: 99%

Martial arts intervention decreases pain scores in children with malignancy

Bluth

Thomas

Cohen³

et al. 2016

PHMT

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BackgroundMartial arts intervention in disease has been mostly limited to adult inflammatory, musculoskeletal, or motor diseases, where a mechanical intervention effects positive change. However, the application and benefit to pain management in childhood malignancy are not well described. Here, we assess the effects of defined martial arts intervention in children with cancer with respect to their pain perception and management.MethodsSixty-four children with childhood malignancies were enrolled in a martial arts program, which encompassed both meditation and movement modalities. Pain scores (0–10) were recorded pre- and post- 1-hour session intervention. Pain scores were crossed by total visits and tabulated by whether participant pain reduced at least 1 unit, stayed the same, or increased in intensity immediately after (post) participation session. Differences in pain scores were further compared by age and sex.ResultsPrepain and postpain scale data were measured for 64 participants, 43 males (67.2%) and 21 females (32.8%), ranging from 3 years to 19 years. Preintervention and postintervention data were obtained for 223 individual session visits. Mean number of patient participation visits was 1.8±1.6 (range one to nine visits). Of 116 individual measured sessions where the participants began with a pain score of at least 1, pain intensity reduced ≥1 unit in 85.3% (99/116) of visits, remained the same in 7.8% (9/116), and increased in 6.9% (8/116). For the majority (96.3%; 77/80) of sessions, participants began with a prepain intensity score of at least 5–10 with reduction in pain intensity following the session. The overall mean pain score presession visit was reduced bŷ40% (pre: 5.95±2.64 and post: 3.03±2.45 [95% CI: 2.34–3.50]; P≤0.001). Median pain intensity scores had greater reductions with increased age of participants (3–6 years [–1], 7–10 years [–2], 11–14 years [–3], and 15–19 years [–4]).ConclusionMartial arts intervention can provide a useful modality to decrease pain in childhood cancer, with greater effect achieved with higher baseline pain scores and patient age. Martial arts intervention may improve patient compliance with respect to medical and surgical management, thus reducing disease morbidity and health care costs.

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Section: Discussionmentioning

confidence: 99%

Martial arts intervention decreases pain scores in children with malignancy

Bluth

Thomas

Cohen³

et al. 2016

PHMT

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“…[15][16][17][18][19][20]23,24 Recent data on the effects of biological effects of martial arts have also been described. To this end, Ho et al 27 reported an increase in blood CD34+ progenitor cells in those engaged in the practice of Tai Chi suggesting its value as an antiaging therapy, while Chyu et al 28 reported an increase in serum insulin growth factor 1 levels, facilitating promotion and maintenance of muscle mass and neuronal function in overweight/obese premenopausal women who participated in a martial arts exercise intervention. 29,30 The application of martial arts intervention in cancer has also been described.…”

Section: Discussionmentioning

confidence: 99%

Martial Arts Intervention Decreases Pain Scores In Children With Malignancy

Cohen

McCrae

O’Malley

et al. 2013

Blood

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Background Martial arts intervention in disease has been mostly limited to inflammatory, musculoskeletal or motor diseases (rheumatoid / osteoarthritis, fibromyalgia, Parkinson’s disease) where a mechanical intervention effects positive change. However, the application and benefit to malignancy is not well described. Methods Ninety four children with childhood malignancies enrolled in a martial arts program which encompassed both “soft” (meditation, chi gung) and “hard” (karate) martial arts platforms over the course of 12 months. Pain scores were recorded pre and post intervention. Data are reported as percent change from baseline pre intervention values compared with post using Wilcoxen Signed Ranks test comparing pain score means for all cases; with significance p< 0.05) Results The majority of participants were African American (>95%) with a M:F ratio of 3:1. Further, most participant scored improvement in pain after 1-3 encounters. Pain scores prior to intervention were recorded on a scale of 0-10. Patients who partook in the martial arts program demonstrated a reduction in pain scores of 14-30.2% (p<0.05) based on mean comparisons as a group or when corrected for number of visits. Differences in pain scores trended as more pronounced in older vs. younger children, but were not significant (p>0.05). Differences in gender were not significant (p>0.05). Conclusion Martial arts can provide a useful modality to decrease pain in childhood cancer. This can improve patient compliance with respect to medical and surgical management thus reducing disease morbidity and healthcare costs. Disclosures: No relevant conflicts of interest to declare.

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“…A possible link between Tai Chi and antiaging effects might involve epigenetic regulation of progenitor cell proliferation. Notably, Tai Chi practitioners were observed to have an increase in the levels of CD34+ progenitors in peripheral blood that correlated with promotion of regenerative health [125]. …”

Section: Explication Of the Hypothesismentioning

confidence: 99%

Epigenetic Mechanisms of Integrative Medicine

Kanherkar

Stair

Bhatia‐Dey

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Since time immemorial humans have utilized natural products and therapies for their healing properties. Even now, in the age of genomics and on the cusp of regenerative medicine, the use of complementary and alternative medicine (CAM) approaches represents a popular branch of health care. Furthermore, there is a trend towards a unified medical philosophy referred to as Integrative Medicine (IM) that represents the convergence of CAM and conventional medicine. The IM model not only considers the holistic perspective of the physiological components of the individual, but also includes psychological and mind-body aspects. Justification for and validation of such a whole-systems approach is in part dependent upon identification of the functional pathways governing healing, and new data is revealing relationships between therapies and biochemical effects that have long defied explanation. We review this data and propose a unifying theme: IM's ability to affect healing is due at least in part to epigenetic mechanisms. This hypothesis is based on a mounting body of evidence that demonstrates a correlation between the physical and mental effects of IM and modulation of gene expression and epigenetic state. Emphasis on mapping, deciphering, and optimizing these effects will facilitate therapeutic delivery and create further benefits.

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Tai Chi Intervention Increases Progenitor CD34⁺ Cells in Young Adults

Cited by 8 publications

References 45 publications

Martial arts intervention decreases pain scores in children with malignancy

Martial arts intervention decreases pain scores in children with malignancy

Martial Arts Intervention Decreases Pain Scores In Children With Malignancy

Epigenetic Mechanisms of Integrative Medicine

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Tai Chi Intervention Increases Progenitor CD34+ Cells in Young Adults

Cited by 8 publications

References 45 publications

Martial arts intervention decreases pain scores in children with malignancy

Martial arts intervention decreases pain scores in children with malignancy

Martial Arts Intervention Decreases Pain Scores In Children With Malignancy

Epigenetic Mechanisms of Integrative Medicine

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Tai Chi Intervention Increases Progenitor CD34⁺ Cells in Young Adults