Tai Chi on bone mineral density of postmenopausal osteoporosis: a protocol for systematic review and meta-analysis

Wu, H. R.; Wang, Yiru; Wen, Guowei; Tang, Zhenyin; Yu, Yiqun; Zhang, Jiren; Liu, Ping; Wu, Junhao

doi:10.37766/inplasy2020.7.0104

Cited by 2 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[3] BMD is a general indicator for fractures in osteoporosis. [4,5] Low BMD usually induces fractures and finally leads to death, functional debility and decreased life quality. [6] Many risk factors are related to the occurrence of distal radius fracture.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Genetic association between bone mineral density and the fracture of distal radius

Li¹,

Fu²,

Gao³

et al. 2021

Medicine

View full text Add to dashboard Cite

Low bone mineral density (BMD) was significantly related to the fracture of distal radius. Serum brain-derived neurotrophic factor (BDNF) level was closely related to BMD in spine and osteoporotic fractures. In this study, we aimed to explore the association of BDNF polymorphisms (rs6265 and rs7124442) with BMD and the fracture of distal radius. This retrospective study included 152 patients with distal radius fractures and 148 healthy controls. BDNF polymorphisms were detected via TaqMan allelic discrimination assay. BMD was evaluated through X-ray. Difference in features between cases and controls were compared adopting Chi-square test or t test. The associations of BDNF polymorphisms with fracture risk of distal radius and BMD were assessed employing χ 2 test and expressed by odd ratios (ORs) with 95% confidence intervals (95% CIs). BMD was significantly decreased in patients with the fracture of distal radius than in healthy controls. The polymorphism rs6265 significantly increased the risk of distal radius fracture (adjustment: GA: OR = 1.724, 95%CI = 1.003 –2.951, P = .049; GG: OR = 2.415, 95%CI = 1.0219 –3.674, P = .005). Moreover, rs6265 genotypes GA (OR = 4.326, 95%CI = 1.725 –11.896, P = .003) and GG (OR = 13.285, 95%CI = 3.659 –51.072, P = .001) significantly increased BMD reduction. However, BDNF polymorphism rs7124442 had no obvious correlation with BMD or fracture risk. BMD was associated with BDNF rs6265 polymorphism. BDNF polymorphism rs6265 could elevate the risk of osteoporosis and distal radius fracture.

show abstract

Section: Introductionmentioning

confidence: 99%

“…It has been found that the fracture of distal radius was significantly associated with low bone mineral density (BMD) [3] . BMD is a general indicator for fractures in osteoporosis [4,5] . Low BMD usually induces fractures and finally leads to death, functional debility and decreased life quality [6] .…”

Section: Introductionmentioning

confidence: 99%

Genetic association between bone mineral density and the fracture of distal radius

Li¹,

Fu²,

Gao³

et al. 2021

Medicine

View full text Add to dashboard Cite

show abstract

“…[3] The number of osteoporotic fracture cases is projected to reach 4.5 million a year by 2025 [3] and the direct treatment of osteoporotic fractures costs between 5000 and 6500 billion dollars per year in Canada, Europe, and the USA alone, based on a systematic review published in 2020. [3] At present, western medicines (e.g., bisphosphonates, teriparatide, and calcitonin), [4][5][6] traditional Chinese medicine, [7] traditional Chinese exercises (e.g., Wuqinxi and Taijiquan), [8,9] acupuncture therapy, [10] and dietary supplements (e.g., calcium and vitamin D) [11] are commonly used as interventions for osteoporosis. Meta-analyses are considered as the highest level of evidence in the era of evidence-based medicine, [12] with many of these reviews on the interventions for osteoporosis published in peer-reviewed journals.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological and non-pharmacological interventions for osteoporosis

Tian

Wu²,

Dong

et al. 2021

Medicine

View full text Add to dashboard Cite

Background: Osteoporosis is a common bone disease that has a significant social and economic effect. Many meta-analyses of pharmacological and non-pharmacological treatments for osteoporosis have been reported, but the findings may be contradictory, and both the reporting and methodological quality remain unknown. As a result, an overview that includes a network meta-analysis was proposed to address these issues. Methods: The Cochrane library, PubMed, Embase, CBM, and CNKI databases will be systematically searched for meta-analyses of osteoporosis interventions from inception to May 2021. In order to evaluate the reporting and methodological quality of each included meta-analysis, Preferred Reporting Items for Systematic Review and Meta-analysis 2020 (PRISMA-2020), and A MeaSurement Tool to Assess systematic Reviews 2 (AMSTAR-2) will be used. For the assessment of the relative efficacy and safety of treatments reported in the randomized controlled trials included in the meta-analyses identified by the overview, a Bayesian network meta-analysis will be carried out. The odds ratio and standard mean difference with their 95% credible intervals will be used to present the binary and continuous outcomes, respectively, and the Grading of Recommendations Assessment, Development and Evaluation method will be used to determine the certainty of the evidence through Confidence In Network Meta-Analysis. Data analysis will be performed using WinBUGS, R, and Stata, with a 2-sided P < .05 considered as statistically significant. Results: The findings of this overview, which includes a network meta-analysis, will be submitted to a peer-reviewed journal for publication. Conclusion: An overview with network meta-analysis will provide evidence on the efficacy and safety of pharmacological and non-pharmacological interventions for osteoporosis, while also identifying the flaws in previously published meta-analyses. All of these results may be used to improve clinical decision-making and future studies. INPLASY registration number: INPLASY202150022.

show abstract

Tai Chi on bone mineral density of postmenopausal osteoporosis: a protocol for systematic review and meta-analysis

Cited by 2 publications

References 0 publications

Genetic association between bone mineral density and the fracture of distal radius

Genetic association between bone mineral density and the fracture of distal radius

Pharmacological and non-pharmacological interventions for osteoporosis

Contact Info

Product

Resources

About