Tailor-made conductive PANI-coated nanofibers for tissue engineering applications

Daraeinejad, Zohreh; Shabani, Iman

doi:10.1016/j.synthmet.2022.117049

Cited by 9 publications

(6 citation statements)

References 53 publications

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“…Also, the two peaks at 2858 and 2941 cm −1 corresponded to the symmetric and asymmetric CH 2 stretching, respectively [66]. The two characteristic peaks at 1575 cm −1 and 1490 cm −1 are attributed to the C-C stretching of the quinonoid and benzenoid rings in the PANI-containing samples [24,67]. During doping there is a prominent peak around 1139 cm −1 , related to -NH•+= structure [68] which can be overlapped with the sharp peak of neat PCL at 1160 cm −1 .…”

Section: Surface Chemistry Assessmentmentioning

confidence: 93%

“…Another equally important factor in the final morphology of PANI is aniline concentration [24]. It was observed that the more the aniline monomer concentration was utilized, the more PANI structures were deposited on the PCL sheet.…”

Section: Cardiac Patches Characterizations 321 Field Emission Scannin...mentioning

confidence: 99%

“…However, some studies have shown that PANI shows remarkable cytotoxicity, mainly caused by the impurities in the structure, dopant type, and concentration, and not related to the polymer backbone [21,22]. For example, the base form of PANI represented a more favorable cytocompatibility compared to the PANI doped with HCl [23,24]. The substitution of common cytotoxic dopants with a biocompatible one can be an effective approach to address this issue [24].…”

Section: Introductionmentioning

confidence: 99%

“…For example, the base form of PANI represented a more favorable cytocompatibility compared to the PANI doped with HCl [23,24]. The substitution of common cytotoxic dopants with a biocompatible one can be an effective approach to address this issue [24]. Furthermore, PANI has been known for its ability to be an effective reactive oxygen species (ROS) scavenger similar to phenolic antioxidants (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…It has been reported that PANI cannot effectively be electrospun due to its high charge density, lack of proper backbone flexibility, and low solubility in usual solvents [24]. Most of the conductive polymers also represent low degradability [9].…”

Section: Introductionmentioning

confidence: 99%

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Fabrication of a tailor-made conductive polyaniline/ascorbic acid-coated nanofibrous mat as a conductive and antioxidant cell-free cardiac patch

Moradikhah,

Shabani,

Tafazzoli Shadpour

2024

Biofabrication

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Polyaniline (PANI) was in-situ polymerized on nanofibrous polycaprolactone mats as cell-free antioxidant cardiac patches (CPs), providing electrical conductivity and antioxidant properties. The fabricated CPs took advantage of intrinsic and additive antioxidant properties in the presence of PANI backbone and ascorbic acid as a biocompatible dopant of PANI. The antioxidant nature of CPs may reduce the serious repercussions of oxidative stress, produced during the ischemia-reperfusion (I/R) process following myocardial infarction. The polymerization parameters were considered as Aniline (60 mM, 90 mM, and 120 mM), ascorbic acid concentrations ([aniline]:[ascorbic acid]=3:0, 3:0.5, 3:1, 3:3), and polymerization time (1h and 3h). Mainly, the more aniline concentrations and polymerization time, the less sheet resistance was obtained. 1,1 diphenyl-2-picrylhydrazyl (DPPH) assay confirmed the dual antioxidant properties of prepared samples. The advantage of the employed in-situ polymerization was confirmed by the de-doping/re-doping process. Non-desirable groups were excluded based on their electrical conductivity, antioxidant properties, and biocompatibility. The remained groups protected H9c2 cells against oxidative stress and hypoxia conditions. Selected CPs reduced the intracellular ROS content and mRNA level of caspase-3 while the bcl-2 mRNA level was improved. Also, the selected cardiac patch could attenuate the hypertrophic impact of hydrogen peroxide on H9c2 cells. The in vivo results of the skin flap model confirmed the CP potency to attenuate the harmful impact of I/R.

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