Tailor-made heart simulation predicts the effect of cardiac resynchronization therapy in a canine model of heart failure

Panthee, Nirmal; Okada, Junichi; Washio, Takumi; Mochizuki, Youhei; Suzuki, Ryôhei; Koyama, Hidekazu; Ōno, Minoru; Hisada, Toshiaki; Sugiura, Seiryo

doi:10.1016/j.media.2016.02.003

Cited by 16 publications

(15 citation statements)

References 60 publications

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“…In particular, the rapidly activating delayed rectifier dominates over the slowly activating form, which has important implications for repolarization reserve. Canine: epicardial model from Hund and Rudy 37 (see also the work by Benson et al 38 and Panthee et al 39 ), showing the pronounced I to,f expression in these cells, which is responsible for the characteristic peak and dome action potential (AP) of this cell type and alters time courses of both I CaL and sarcoplasmic reticulum calcium release. Rabbit: the rabbit model of Shannon et al 40 (see also the work by Restrepo et al 41 ) was one of the first to accurately reflect large mammal excitation-contraction coupling.…”

Section: Species Differences In Cardiomyocyte Electrophysiologymentioning

confidence: 99%

Species-Dependent Mechanisms of Cardiac Arrhythmia: A Cellular Focus

Edwards

Louch

2017

Clin Med Insights Cardiol

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Although ventricular arrhythmia remains a leading cause of morbidity and mortality, available antiarrhythmic drugs have limited efficacy. Disappointing progress in the development of novel, clinically relevant antiarrhythmic agents may partly be attributed to discrepancies between humans and animal models used in preclinical testing. However, such differences are at present difficult to predict, requiring improved understanding of arrhythmia mechanisms across species. To this end, we presently review interspecies similarities and differences in fundamental cardiomyocyte electrophysiology and current understanding of the mechanisms underlying the generation of afterdepolarizations and reentry. We specifically highlight patent shortcomings in small rodents to reproduce cellular and tissue-level arrhythmia substrate believed to be critical in human ventricle. Despite greater ease of translation from larger animal models, discrepancies remain and interpretation can be complicated by incomplete knowledge of human ventricular physiology due to low availability of explanted tissue. We therefore point to the benefits of mathematical modeling as a translational bridge to understanding and treating human arrhythmia.

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Section: Species Differences In Cardiomyocyte Electrophysiologymentioning

confidence: 99%

Species-Dependent Mechanisms of Cardiac Arrhythmia: A Cellular Focus

Edwards

Louch

2017

Clin Med Insights Cardiol

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“…The details of our multi-scale, multi-physics heart simulator and its personalization technique have been described elsewhere [13,[15][16][17][18][19] and can be seen in the Supplementary material of this article. Briefly, patient-specific 3D FE models of the ventricles and upper body (torso) were reconstructed from multi-slice CT or magnetic resonance imaging data.…”

Section: Patient-specific Models Of the Failing Heartmentioning

confidence: 99%

“…points using custom-made software [19]. Using the same software, we also evaluated the dyssynchrony by calculating the circumferential uniformity ratio estimate (CURE) of the simulation model (CURE sim ), according to the literature [27].…”

Section: Virtual Tissue Trackingmentioning

confidence: 99%

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Multi-scale, tailor-made heart simulation can predict the effect of cardiac resynchronization therapy

Okada

Washio

Nakagawa

et al. 2017

Journal of Molecular and Cellular Cardiology

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“…It may help to solve complex problems involving big data by identifying interaction patterns among multiple variables in potential CRT candidates [91, 92]. The application of neural networks and deep learning in cardiovascular medicine plays a crucial role in imaging accusation, reconstruction, quantification, and analysis [93].…”

Section: Advanced Computer Modelingmentioning

confidence: 99%

Cardiac Resynchronization Therapy Optimization: A Comprehensive Approach

et al. 2019

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Since the first report on biventricular pacing in 1994, cardiac resynchronization therapy (CRT) has become standard for patients with advanced heart failure (HF) and ventricular conduction delay. CRT improves myocardial function by resynchronizing myocardial contraction, which results in reverse left ventricular remodeling and improves symptoms and clinical outcomes. Despite the accelerated development of CRT device technology and its increased application in treating HF patients, almost one-third of these patients do not respond to the therapy or gain any clinical benefit from device implantation. Over the last decade, multiple cardiac imaging modalities have provided a deeper understanding of myocardial pathophysiology, thereby improving HF treatment management. However, the optimal strategy for improving the CRT response remains debatable. This article provides an updated overview of the electropathophysiology of myocardial dysfunction in ventricular conduction delay and the diagnostic approaches involving the use of multiple modalities.

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Tailor-made heart simulation predicts the effect of cardiac resynchronization therapy in a canine model of heart failure

Cited by 16 publications

References 60 publications

Species-Dependent Mechanisms of Cardiac Arrhythmia: A Cellular Focus

Species-Dependent Mechanisms of Cardiac Arrhythmia: A Cellular Focus

Multi-scale, tailor-made heart simulation can predict the effect of cardiac resynchronization therapy

Cardiac Resynchronization Therapy Optimization: A Comprehensive Approach

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