Tailor-made isostructural copper(ii) and nickel(ii) complexes with a newly designed (N,N)-donor scaffold as functional mimics of alkaline phosphatase

Abstract

This study highlights the design, synthesis, spectroscopic characterization and catalytic phosphoesterase cleavage activity of two isostructural and isomorphous complexes, [Cu(L)]4 (1) and [Ni(L)]2.CH3OH (2) containing a newly synthetic N,N-type donor...

AIE active fluorescent organic nanoparticles based optical detection of Cu2+ ions in pure water: a case of aggregation–disaggregation reversibility

“…This might result from the disaggregation of FONs and formation of a 2 : 1 (1 : Cu 2+ ) complex. 79,80 Based on the above discussion, we might propose the following possible mechanism (Scheme 2).…”

A square planar copper(II) complex noncovalently conjugated with a p-cresol for bioinspired catecholase activity

“…The Cu(II) complex displayed the electronic bands at 315 and 382 nm in ACN at room temperature. The electronic bands at 315 and 382 nm in the complex can be assigned to the presence of π → π* and charge transfer (CT) transitions, respectively [2,3].…”

“…Copper is one of the precious biometals, principally for its significant contributions to biological processes and its captivating synergism with therapeutics [1,2]. Copper plays a pivotal role in cell physiology as a catalytic cofactor in the redox events of mitochondrial respiration, free radical scavenging, iron absorption, and elastin crosslinking [3][4][5].…”

Copper (II) complexes based on the mixed ligand system: Study of synthesis, characterization, and stopped‐flow kinetics of copper oxidase‐mimicking catalytic activity

“…Biomimetic chemistry is a new scientific window that opens the way for further understanding of the role of the metal center in preparing the metalloprotein to carry out its biological function. More effort and research are needed to understand the function of metalloproteinases and create small molecular mass biomimetics that can be used to achieve the activity of the native protein in its absence more deeply 34–36 …”

“…More effort and research are needed to understand the function of metalloproteinases and create small molecular mass biomimetics that can be used to achieve the activity of the native protein in its absence more deeply. [34][35][36] Metalloproteins are metal complexes of mixed ligand systems because the ligand system provides the metal center with properties that improve its catalytic performance. 1 In the same context, oxygen and nitrogen are the most common donor atoms in many known natural metalloproteins.…”