Tailor made magnetic nanolights: fabrication to cancer theranostics applications

Das, Poushali; Ganguly, Sayan; Margel, Shlomo; Gedanken, Aharon

doi:10.1039/d1na00447f

Cited by 94 publications

(38 citation statements)

References 254 publications

(255 reference statements)

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“…Carbon dots (Cdots) are a new class of carbon nanomaterials with interesting optical properties, such as high emission yields, excitation wavelength dependent emission, and high photostability. When combined with secondary properties, such as low toxicity, chemical stability, and water solubility, this makes them uniquely suited for applications in bioimaging, sensing, nanomedicine, catalysis, lightning, and photonics [ 1 , 2 , 3 , 4 , 5 , 6 ]. Cdots can be easily prepared by top–down and bottom–up approaches using low-cost and environmentally-friendly materials.…”

Section: Introductionmentioning

confidence: 99%

A Fluorescent Nanosensor for Silver (Ag+) and Mercury (Hg2+) Ions Using Eu (III)-Doped Carbon Dots

2022

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Carbon dots doped with Eu3+ ions (Eu-Cdots) were prepared by a hydrothermal treatment, using citric acid and urea as precursors and Eu (NO3)3 as a europium source. The Eu3+ ions are strongly coordinated with the carboxylate groups at the surface of the Cdots and incorporated within the nanographene network in the carbon core. Vibrational spectroscopy provides evidence of such interaction with identification of bands assigned to the stretching of the Eu-O bond. Eu3+ doped Cdots have larger diameters then undoped Cdots, but they are divided into smaller domains of sp2 carbon. The UV-vis excitation spectrum provides evidence of energy transfer from the Cdots to the Eu3+. The luminescence spectrum shows the characteristic sharp peaks of Eu3+ in the red part of the visible spectrum and a broad emission of Cdots centered at 450 nm. The luminescence of the Cdots is strongly quenched by Hg2+ and Ag+, but not by other cations. The quenching mechanism differs significantly depending on the nature of the ion. Both the blue emission of Cdots and the red emission of Eu3+ are quenched in the presence of Hg2+ while only the emission of the Cdots is affected by the presence of Ag+. A ratiometric sensor can be built using the ratio of luminescence intensities of the Cdots to the Eu3+ peaks.

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Section: Introductionmentioning

confidence: 99%

A Fluorescent Nanosensor for Silver (Ag+) and Mercury (Hg2+) Ions Using Eu (III)-Doped Carbon Dots

2022

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“…Various fluorescent nanoparticles and QDs have been widely explored for cancer theranostics. However, several challenges regarding the surface functionalization, biocompatibility, simplicity of synthesis process, and possible environmental hazards have impeded their future clinical and biomedical appliances [ 77 ]. Therefore, the investigational priority should be focused on one-step greener synthesis techniques with cost-effectiveness, high yields/safety, simplicity, and optimized conditions to generate multifunctional nanostructures with high biocompatibility and efficiency.…”

Section: Biomedical Advancementsmentioning

confidence: 99%

Smart MXene Quantum Dot-Based Nanosystems for Biomedical Applications

Iravani

Varma

2022

Nanomaterials

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MXene quantum dots (QDs), with their unique structural, optical, magnetic, and electronic characteristics, are promising contenders for various pharmaceutical and biomedical appliances including biological sensing/imaging, cancer diagnosis/therapy, regenerative medicine, tissue engineering, delivery of drugs/genes, and analytical biochemistry. Although functionalized MXene QDs have demonstrated high biocompatibility, superb optical properties, and stability, several challenging issues pertaining to their long-term toxicity, histopathology, biodistribution, biodegradability, and photoluminescence properties are still awaiting systematic study (especially the move towards the practical and clinical phases from the pre-clinical/lab-scale discoveries). The up-scalable and optimized synthesis methods need to be developed not only for the MXene QD-based nanosystems but also for other smart platforms and hybrid nanocomposites encompassing MXenes with vast clinical and biomedical potentials. Enhancing the functionalization strategies, improvement of synthesis methods, cytotoxicity/biosafety evaluations, enriching the biomedical applications, and exploring additional MXene QDs are crucial aspects for developing the smart MXene QD-based nanosystems with improved features. Herein, recent developments concerning the biomedical applications of MXene QDs are underscored with emphasis on current trends and future prospects.

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“…When MNPs are utilized, the oscillating magnetic field emits radiation that is only felt by the nanoparticles as opposed to the entire body, which is ideal for non-invasive therapy [ 50 ]. MNPs can easily permeate through the blood–brain barrier, which is desirable for glioblastoma treatment [ 51 , 52 ]. MNPs are also deliverable with drug molecules [ 53 ].…”

Section: Magnetic Nanoparticles (Mnps) In Hyperthermiamentioning

confidence: 99%

Design of Magnetic Hydrogels for Hyperthermia and Drug Delivery

Ganguly

Margel

2021

Polymers

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Hydrogels are spatially organized hydrophilic polymeric systems that exhibit unique features in hydrated conditions. Among the hydrogel family, composite hydrogels are a special class that are defined as filler-containing systems with some tailor-made properties. The composite hydrogel family includes magnetic-nanoparticle-integrated hydrogels. Magnetic hydrogels (MHGs) show magneto-responsiveness, which is observed when they are placed in a magnetic field (static or oscillating). Because of their tunable porosity and internal morphology they can be used in several biomedical applications, especially diffusion-related smart devices. External stimuli may influence physical and chemical changes in these hydrogels, particularly in terms of volume and shape morphing. One of the most significant external stimuli for hydrogels is a magnetic field. This review embraces a brief overview of the fabrication of MHGs and two of their usages in the biomedical area: drug delivery and hyperthermia-based anti-cancer activity. As for the saturation magnetization imposed on composite MHGs, they are easily heated in the presence of an alternating magnetic field and the temperature increment is dependent on the magnetic nanoparticle concentration and exposure time. Herein, we also discuss the mode of different therapies based on non-contact hyperthermia heating.

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Tailor made magnetic nanolights: fabrication to cancer theranostics applications

Abstract: Nanoparticles having magnetic and fluorescent properties could be considered as a gift to materials scientists due to their unique magneto-optical qualities. Multiple component particles can overcome challenges related with a...

Cited by 94 publications

References 254 publications

A Fluorescent Nanosensor for Silver (Ag+) and Mercury (Hg2+) Ions Using Eu (III)-Doped Carbon Dots

A Fluorescent Nanosensor for Silver (Ag+) and Mercury (Hg2+) Ions Using Eu (III)-Doped Carbon Dots

Smart MXene Quantum Dot-Based Nanosystems for Biomedical Applications

Design of Magnetic Hydrogels for Hyperthermia and Drug Delivery

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