Tailor made Pharmacokinetics of Peptides by Transient PEGylation

Biobetters

“…Depending on temperature and pH, both precisely controlled in the human body fl uids, the linker undergoes autohydrolysis and slowly releases the unmodifi ed, fully active protein (Hersel et al 2009 ). A correspondingly modifi ed hGH is under current investigation in several phase II clinical studies.…”