Tailored 70S30C Bioactive glass induces severe inflammation as pulpotomy agent in primary teeth: an interim analysis of a randomised controlled trial

Sol-gel synthesis of lithium doped mesoporous bioactive glass nanoparticles and tricalcium silicate for restorative dentistry: Comparative investigation of physico-chemical structure, antibacterial susceptibility and biocompatibility

“…It should be kept in mind that the in vitro environment of our study in which MG63 cells were employed, differs from an in vivo environment where materials are in contact with odontoblast cells. That notwithstanding, our current results provide a rational basis to conduct subsequent studies that employ pulp stem cells and in doing so, these studies contribute to the direct comparison of the two compounds as recommended by the authors of the clinical trial ( Elhamouly et al, 2021 ).…”

“…MBGNs have routinely been considered to favour cell growth and proliferation ( Amudha et al, 2020 ) even though the suitability, comparability and interpretation of biological studies by different authors is debatable ( Salètes et al, 2021 ). At the same time, although a clinical study on sol-gel BAG for pulp capping attributes the negative outcomes of the said BAG to the biodegradability and high pH of the glass ( Elhamouly et al, 2021 ), our results demonstrate that a high pH should not necessarily result in unfavorable sequalae. We observed that despite TCS particles being responsible for the highest increase in pH, TCS supported cell viability as well.…”

“…On the contrary, TCS based materials are the current most recommended products for promoting dentine regeneration in clinical dental practice, with a proven track record of good performance ( Guivarc’h et al, 2020 ). Preliminary application of pulp capping material based on bioactive glass in children affected by pulpitis, led to unexpected negative outcomes in one of the latest clinical trials ( Elhamouly et al, 2021 ). Beyond the reasons portrayed by the authors for the undesirable results of the trial, the conditions of synthesis of BAG must be also considered as they influence the characteristics of the nanoparticles affecting also their biological performance ( Simila and Boccaccini, 2022 ).…”

Present status and future directions: Hydraulic materials for endodontic use

“…Sixteen articles were reviewed where this technique was not only applied in mainly primary teeth (Alsanouni & Bawazir, 2019; Cardoso‐Silva et al, 2011; Carti et al, 2017; Çelik et al, 2019; Cuadros‐Fernández et al, 2016; Doyle et al, 2010; Elhamouly et al, 2021; Kang et al, 2015a; Liu et al, 2011; Lourenço Neto et al, 2015; Silva et al, 2019; Vilella‐Pastor et al, 2021) but also immature permanent teeth (four studies, Table 5). Carious and traumatic pulp exposures were the main aetiological reasons.…”

“…More specifically, interproximal exposure may have an unfavourable prognosis, due to the fact that it is less accessible than an occlusal lesion, with respect to caries removal, application of biomaterials and sealing ability (Cho et al, 2013; Kang et al, 2015a, 2017). Several included articles have not taken these factors into account in their eligibility criteria (Carti et al, 2017; Elhamouly et al, 2021; Lourenço Neto et al, 2015). Additionally, the aetiological reason of the exposed pulp (caries, trauma or accidental mechanical) defines the microbiological load of the pulp.…”