2023
DOI: 10.1002/adhm.202301726
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Tailored Drug Delivery Platforms: Stimulus‐Responsive Core–Shell Structured Nanocarriers

Yulong Shi,
Yiran Zhang,
Liangliang Zhu
et al.

Abstract: Core‐shell structured nanocarriers have come into the scientific spotlight in recent years due to their intriguing properties and wide applications in materials chemistry, biology, and biomedicine. Tailored core‐shell structures to achieve desired performances has emerged as a research frontier in the development of smart drug delivery system. However, a systematic review on the design and loading/release mechanisms of stimulus‐responsive core‐shell structured nanocarriers is seldom available. This review star… Show more

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Cited by 27 publications
(10 citation statements)
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“…15,16 Stimulus-responsive nanocarriers possess favorable attributes for the construction of a drug-delivery platform through the combination of ICD inducers and PD-1/PD-L1 inhibitors. Attributes as follows: (i) introduction of stimulus-responsive materials to reconstruct TEM, which is conducive to the acquisition of long-term immune memory after the release of ICD inducers and PD-1/PD-L1 inhibitors; 17 (ii) unifying ICD inducers and PD-1/PD-L1 inhibitors with different distributions and different targets in vivo in nanocarrier to obtain better synergistic antitumor effect; 18 (iii) avoiding the systemic toxic side effects of ICD inducers and PD-1/PD-L1 inhibitors alone; 19 and (iv) controlling the release of ICD inducers and PD-1/PD-L1 inhibitors and exerting synergistic antitumor effects. 20 In the past few years, our group has published several papers in the field of stimulus-responsive nanocarriers and accumulated some experience, which effectively provided technical support for the writing of this review.…”
Section: Introductionmentioning
confidence: 99%
“…15,16 Stimulus-responsive nanocarriers possess favorable attributes for the construction of a drug-delivery platform through the combination of ICD inducers and PD-1/PD-L1 inhibitors. Attributes as follows: (i) introduction of stimulus-responsive materials to reconstruct TEM, which is conducive to the acquisition of long-term immune memory after the release of ICD inducers and PD-1/PD-L1 inhibitors; 17 (ii) unifying ICD inducers and PD-1/PD-L1 inhibitors with different distributions and different targets in vivo in nanocarrier to obtain better synergistic antitumor effect; 18 (iii) avoiding the systemic toxic side effects of ICD inducers and PD-1/PD-L1 inhibitors alone; 19 and (iv) controlling the release of ICD inducers and PD-1/PD-L1 inhibitors and exerting synergistic antitumor effects. 20 In the past few years, our group has published several papers in the field of stimulus-responsive nanocarriers and accumulated some experience, which effectively provided technical support for the writing of this review.…”
Section: Introductionmentioning
confidence: 99%
“…Recently, with the development of nanomaterial architectures, a class of MOF nanostructure, MOF-on-MOF, has gathered considerable interest. , MOF-on-MOF nanocomposites are predominantly formed through growing guest MOF onto presynthesized host MOF with identical or diverse architectures, creating core–shell, hollow multishell, yolk–shell, core–satellite, or asymmetric structures. , Compared to traditional MOF, MOF-on-MOF composites have demonstrated improved performance in gas adsorption/separation, detection, and catalysis. , In drug delivery systems, core–shell nanoparticles have major advantages over simple nanoparticles leading to the improvement of properties including decreased cytotoxicity, enhanced dispersibility, biocompatibility, strengthened affinity with biomolecules and drugs due to improved surface properties, and enhanced thermal and chemical stability. …”
Section: Introductionmentioning
confidence: 99%
“…The development of stimulus-triggered drug carrier systems, which integrate stimulus-responsive components with the therapeutic agents, represents a strategic innovation aimed at achieving precise and timely drug delivery [ 4 , 5 , 6 ]. This approach is responsive to both internal (e.g., pH, temperature, enzymes) and external (e.g., light, magnetic field) stimuli, thereby enhancing drug bioavailability and minimizing the adverse effects associated with chemotherapy [ 5 , 6 ].…”
Section: Introductionmentioning
confidence: 99%