Tailored Hydrogel Microbeads of Sodium Carboxymethylcellulose as a Carrier to Deliver Mefenamic Acid: Transmucosal Administration

Shirizadeh, Babak; Maghsoodi, Maryam; Alami-Milani, Mitra; Salatin, Sara

doi:10.5812/jjnpp.65324

Cited by 3 publications

(3 citation statements)

References 29 publications

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“…The hydration of these functional groups resulted in water entry into the polymer network, leading to expansion. Moreover, the hydrophilic functional groups of CMC Na form hydrogen bonds with the mucus layer (69,70). The increase in CMC Na concentration led to further increase in mucoadhesive strength.…”

Section: Discussionmentioning

confidence: 99%

Chronological Delivery of Antihypertensive Drugs in Bilayered Core-in-Cup Buccoadhesive Tablets: In Vitro and In Vivo Evaluation

et al. 2019

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Hypertension shows circadian blood pressure rhythms (day-night pattern) that urge the delivery of antihypertensive drugs at the right time in the desired levels. Thus, a bilayered core-in-cup buccoadhesive tablet was formulated that immediately releases olmesartan, to give a burst effect, and controls azelnidipine release, to prolong its therapeutic effect. The main challenge was the poor bioavailability of azelnidipine due to its poor aqueous solubility and first-pass effect. Hence, liquisolid compact buccoadhesive tablets were prepared to enhance solubility, dissolution profiles, and bypass the oral route. Two factorial designs were conducted to study the type and concentration effect of the mucoadhesive polymers on the dissolution and mucoadhesion of olmesartan and azelnidipine. Characterization studies were conducted regarding drug content, surface pH, water uptake, mucoadhesive strength, in vitro release, and ex vivo permeability. The core-in-cup olmesartan/azelnidipine buccoadhesive tablet showed similar release profile to the statistically optimized formulae of each drug. In vitro dissolution study showed enhanced release of azelnidipine than the directly compressed tablets, to comply with the regulatory standards of controlled release systems. In vivo pharmacokinetic study of olmesartan and azelnidipine conducted on human volunteers against Rezaltas® 10/8 mg tablet showed percentage relative bioavailability of 106.12 and 470.82%, respectively.

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Section: Discussionmentioning

confidence: 99%

Chronological Delivery of Antihypertensive Drugs in Bilayered Core-in-Cup Buccoadhesive Tablets: In Vitro and In Vivo Evaluation

et al. 2019

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“…The ionotropic gelation method was used in the preparation of floating hydrogel pellets. [29][30][31] First of all, the different amounts of pectin were swelled homogeneously on a multi-point magnetic stirrer (2mag, MIX 15 eco) at 750 rpm in ultrapure water. Then, while mixing at the same speed, PG and NaHCO 3 (as a source of CO 2 ) were added in determining amounts, and it was completely dissolved.…”

Section: Preparation Of Floating Pregabalin Hydrogel Pellet Formulationsmentioning

confidence: 99%

Development and in vitro Characterization of Gastroretentive Formulations as Calcium Pectinate Hydrogel Pellets of Pregabalin by Ionotropic Gelation Method

Özakar¹

2022

IJPER

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Introduction: Pregabalin (PG) is primarily prescribed for epilepsy, painful diabetic neuropathy, post-herpetic neuralgia, and fibromyalgia. Also, it is used in clinical practice to treat general anxiety disorder due to its anxiolytic properties. Pectin is a watersoluble ionic polysaccharide. As a result of the interaction of pectin with calcium ions, a hydrophilically coated insoluble carrier system is formed by complexing between surfaces, which provides a sustained release. In this direction, floating hydrogel pellets containing PG were developed and characterized in our study. This study aimed to make a sustained release of PG, reach the optimum level in characterization, and bring a new approach to widely used oral drug therapy. Materials and Methods: PG was a gift from Ilko Pharmaceuticals (Turkey) and pectin was purchased from CPKelco (USA). The ionotropic gelation technique was used to prepare pellets. To characterize the pellets, flotation/swelling degrees, yield, drug loading capacity/encapsulation efficiency, particle size/distribution, in-vitro release/kinetics, and morphological studies have been done. Also, the structural features of pellets have determined via the Fourier Transform Infrared (FT-IR), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET), and X-ray diffraction (XRD) studies. Results: The formulations have been successfully developed without using any coating agent to prolong drug release for 24 h with an encapsulation efficiency of ~82%. Optimum results were obtained in characterization studies. As a result of BET analysis, it has been proven that the structure is porous and there is no change in the chemical and crystal structure of PG by FT-IR and XRD studies. Conclusion:We anticipate that the formulation we developed will provide an alternative to the sustained-release PG preparations in the current pharmaceutical market.

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“…Existing research indicates the substantial potential of polymer nanomicelles owing to their unique characteristics such as mucosal adhesion and small size. These qualities can enhance the bioavailability of medications, facilitate superior corneal penetration and intraocular absorption, decrease eye irritation, and minimize adverse medication reactions (Rupenthal, Green, and Alany, 2011;Enriquez et al, 2013;Kwon et al, 2013;Xu et al, 2013;Franca et al, 2014;Ashley et al, 2016;Salatin et al, 2016;Shirizadeh et al, 2017;Salatin, 2018). Polymeric micelles (PMs), the most successful among the nano-carrier systems, can be readily produced via self-assembly.…”

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confidence: 99%

Recent development of polymer nanomicelles in the treatment of eye diseases

Cai

Zhang

Hao

2023

Front. Bioeng. Biotechnol.

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The eye, being one of the most intricate organs in the human body, hosts numerous anatomical barriers and clearance mechanisms. This highlights the importance of devising a secure and efficacious ocular medication delivery system. Over the past several decades, advancements have been made in the development of a nano-delivery platform based on polymeric micelles. These advancements encompass diverse innovations such as poloxamer, chitosan, hydrogel-encapsulated micelles, and contact lenses embedded with micelles. Such technological evolutions allow for sustained medication retention and facilitate enhanced permeation within the eye, thereby standing as the avant-garde in ocular medication technology. This review provides a comprehensive consolidation of ocular medications predicated on polymer nanomicelles from 2014 to 2023. Additionally, it explores the challenges they pose in clinical applications, a discussion intended to aid the design of future clinical research concerning ocular medication delivery formulations.

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Tailored Hydrogel Microbeads of Sodium Carboxymethylcellulose as a Carrier to Deliver Mefenamic Acid: Transmucosal Administration

Abstract: Background: Mefenamic acid is a nonsteroidal anti-inflammatory drug (NSAID). NSAIDs produce an enhanced hazard of severe gastrointestinal adverse effects, specifically in elderly patients.

Cited by 3 publications

References 29 publications

Chronological Delivery of Antihypertensive Drugs in Bilayered Core-in-Cup Buccoadhesive Tablets: In Vitro and In Vivo Evaluation

Chronological Delivery of Antihypertensive Drugs in Bilayered Core-in-Cup Buccoadhesive Tablets: In Vitro and In Vivo Evaluation

Development and in vitro Characterization of Gastroretentive Formulations as Calcium Pectinate Hydrogel Pellets of Pregabalin by Ionotropic Gelation Method

Recent development of polymer nanomicelles in the treatment of eye diseases

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