Tailored lysozyme–ZnO nanoparticle conjugates as nanoantibiotics

Tripathy, Nirmalya; Ahmad, Rafiq; Bang, Seung Hyuck; Min, Jiho; Hahn, Yoon‐Bong

doi:10.1039/c4cc03712j

Cited by 55 publications

(37 citation statements)

References 27 publications

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“…[3c,4] The development of new antibiotics is one strategy to address the challenges, however new drug discovery is time‐consuming and very costly . Another promising approach for battling bacterial infection is the use of various nanoparticles which have intrinsic antimicrobial properties themselves or using such particles in combination with the existing antibiotics . Silver‐based nanoparticles are powerful antimicrobial agents against a broad range of micro‐organisms .…”

Section: Introductionmentioning

confidence: 99%

Engineering Iron Oxide Hollow Nanospheres to Enhance Antimicrobial Property: Understanding the Cytotoxic Origin in Organic Rich Environment

Nor

Zhou

Meka

et al. 2016

Adv Funct Materials

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Engineered magnetic iron oxide nanoparticles with surprisingly high antimicrobial activity and excellent safety profiles to mammalian cell lines have been developed. Hematite hollow nanospheres (HNSs) are prepared by a facile hard templating method; reduction of hematite HNSs by H2 leads to magnetite HNSs. The antimicrobial activity of magnetite HNSs towards Gram negative (Escherichia coli) and Gram positive (Staphylococcus epidermidis) bacteria is evaluated against hematite HNSs and conventional magnetite (C‐magnetite; diameter <50 nm). Superior antibacterial performance is observed for magnetite HNSs towards both E. coli and S. epidermidis over hematite HNSs and C‐magnetite. The origin of the antimicrobial activity of magnetite HNSs is the high leaching of iron ions in the presence of microorganisms, which leads to high generation of reactive oxygen species. Magnetite HNSs allow multiple‐fold increase in the generation of soluble iron ions over hematite HNSs and C‐magnetite, showing that control over both the composition and nanostructure is crucial to tune the antimicrobial activity of iron oxides. Based on the current findings, magnetic HNSs show promising potential antimicrobial applications.

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Section: Introductionmentioning

confidence: 99%

Engineering Iron Oxide Hollow Nanospheres to Enhance Antimicrobial Property: Understanding the Cytotoxic Origin in Organic Rich Environment

Nor

Zhou

Meka

et al. 2016

Adv Funct Materials

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“…Lysozyme attached to ZnO nanoparticle is another complex. The synergistic effect of lysozyme and ZnO conjugate increases antimicrobial activity against E. coli and S. aureus [43]. …”

Section: Endogenous Antimicrobial Peptides and Their Analogues As Thementioning

confidence: 99%

Endogenous antimicrobial factors in the treatment of infectious diseases

Żelechowska¹,

Agier²,

Brzezińska‐Błaszczyk³

2016

cejoi

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Nowadays, a number of antibiotic-resistant bacteria strains is increasing. It is a serious clinical problem and poses a threat to the effectiveness of conventional antibiotic therapy. Thus, scientists are constantly seeking new alternatives for treatment of infectious diseases. There are some natural endogenous factors, which possess antimicrobial activities against a large number of microorganisms, including both Gram-positive and Gram-negative bacteria, viruses and fungi. These factors are present in all eukaryotic organisms and constitute an essential element of their immune system. A large number of in vitro and in vivo models have been used to show the activity of antimicrobial factors, and only few studies have been conducted on people. Results indicate that administration of these molecules is therapeutically beneficial. This review summarizes knowledge of selected endogenous antimicrobial agents, such as cathelicidins, defensins, histatins, lysozyme and lactoferrin. We also discuss potential uses of these factors in the treatment of infectious diseases.

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“…have been extensively evaluated to synthesize different nonstructural forms of these metal oxides. Among them, zinc oxide (ZnO), an environment-friendly semiconductor (band gap of 3.37 eV) is an interesting metal oxide with several scientific and engineering based applications [4][5][6][7]. This is one of unique materials for the fabrication of facile, high performing and low-cost biosensors.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of highly sensitive uric acid biosensor based on directly grown ZnO nanosheets on electrode surface

Ahmad

Tripathy

Jang

et al. 2015

Sensors and Actuators B: Chemical

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117

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Tailored lysozyme–ZnO nanoparticle conjugates as nanoantibiotics

Abstract: Covalently attached lysozyme-ZnO nanoparticle (L-ZNP) conjugates were synthesized by a low temperature solution route. Tailored L-ZNP conjugates exhibit pronounced antibacterial features against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus).

Cited by 55 publications

References 27 publications

Engineering Iron Oxide Hollow Nanospheres to Enhance Antimicrobial Property: Understanding the Cytotoxic Origin in Organic Rich Environment

Engineering Iron Oxide Hollow Nanospheres to Enhance Antimicrobial Property: Understanding the Cytotoxic Origin in Organic Rich Environment

Endogenous antimicrobial factors in the treatment of infectious diseases

Fabrication of highly sensitive uric acid biosensor based on directly grown ZnO nanosheets on electrode surface

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