Tailored silver nanoparticles capped with gallic acid and its potential toxicity via ROS mediated pathway against osteosarcoma cells

Majeed, Shahnaz; Danish, Mohammed; Zakariya, Norul Aini; Hashim, Rokiah; Ansari, Mohammed T; Sisinthy, Sreenivas Patro

doi:10.1016/j.mtcomm.2022.103844

Cited by 6 publications

(2 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ROS can promote abnormal cell signaling, oxidative cell damage, apoptosis, and several pathophysiological conditions. , Treatment of AgNPs-CGA and AgNPs-CGA-BSA for 24 h induced intracellular ROS generation as induced by DCF fluorescence intensity in DLA cells (Figure A,B), and also, a significant increase in ROS levels was observed by fluorescence spectrophotometry, which indicated oxidative-stress-induced pathophysiological conditions in DLA cells.…”

Section: Results and Discussionmentioning

confidence: 99%

Facile and Green Fabrication of Highly Competent Surface-Modified Chlorogenic Acid Silver Nanoparticles: Characterization and Antioxidant and Cancer Chemopreventive Potential

et al. 2022

View full text Add to dashboard Cite

The eco-friendly, cost-effective, and green fabrication of nanoparticles is considered a promising area of nanotechnology. Here, we report on the green synthesis and characterization of bovine serum albumin (BSA)-decorated chlorogenic acid silver nanoparticles (AgNPs-CGA-BSA) and the studies undertaken to verify their plausible antioxidant and antineoplastic effects. High-resolution transmission electron microscopy (HR-TEM), dynamic light scattering, X-ray diffraction, and Fourier transform infrared analyses depict an average mean particle size of ∼96 nm, spherical morphology, and nanocrystalline structure of AgNPs-CGA-BSA. DPPH scavenging and inhibition of lipid peroxidation signify the noticeable in vitro antioxidant potential of the nanoparticles. The in vitro experimental results demonstrate that AgNPs-CGA-BSA shows significant cytotoxicity to Dalton’s lymphoma ascites (DLA) cells and generates an enhanced intracellular reactive oxygen species and oxidized glutathione (GSSG) and reduced glutathione (GSH) in DLA cells. Furthermore, mechanism investigation divulges the pivotal role of the downregulated expression of superoxide dismutase (SOD) and catalase (CAT), and these ultimately lead to apoptotic chromatin condensation in AgNPs-CGA-BSA-treated DLA cells. In addition, in vivo experiments reveal an excellent decrease in tumor cell count, an increase in serum GSH and CAT, SOD, and glutathione peroxidase activities, and a decrease in the malondialdehyde (MDA) level in DLA-bearing mice after AgNPs-CGA-BSA treatment. These findings suggest that the newly synthesized biogenic green silver nanoparticles have remarkable in vitro antioxidant and antineoplastic efficacy that triggers cytotoxicity, oxidative stress, and chromatin condensation in DLA cells and in vivo anticancer efficacy that enhances the host antioxidant status, and these might open a new path in T-cell lymphoma therapy.

show abstract

Section: Results and Discussionmentioning

confidence: 99%

Facile and Green Fabrication of Highly Competent Surface-Modified Chlorogenic Acid Silver Nanoparticles: Characterization and Antioxidant and Cancer Chemopreventive Potential

et al. 2022

View full text Add to dashboard Cite

show abstract

“…GA possesses hydroxyl groups in its molecular structure and has been used as an antioxidant . Recently, GA-capped AgNPs (GA-AgNPs) have been used as antimicrobial agents, drug nanocarriers, anticancer agents, and colorimetric and spectrophotometric probes for the detection of Al 3+ and melamine. , These results demonstrate that GA-AgNPs used as sensing probes exhibit excellent selectivity and sensitivity. In this study, GA acted as a stabilizing agent and sodium borohydride (NaBH 4 ) as a reducing agent for the preparation of GA-AgNPs.…”

Section: Introductionmentioning

confidence: 97%

Ag Nanoparticles Decorated by Gallic Acid as a Colorimetric Sensor for the Detection of Cartap Pesticide

Wang,

Chiu,

et al. 2023

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

This study presents a facile approach for synthesizing gallic acid-capped silver nanoparticles (GA-AgNPs). GA-AgNPs were synthesized under the optimized conditions and characterized using various techniques [ultraviolet−visible, Fouriertransformed infrared (FTIR), X-ray diffraction, and transmission electron microscopy]. GA-AgNPs were spherical in shape with an average diameter of 11.2 nm. The FTIR and zeta potential analyses proved the presence of GA on the surface of AgNPs, stabilizing the nanoparticles. GA-AgNPs were used for the colorimetric detection of cartap (S,S′-[2-(dimethylamino)-1,3-propanediyl]dicarbamothioate). GA-AgNPs were highly selective and sensitive to cartap, with a detection limit of 0.059 ppm in a linear range of 0.1−2.0 ppm. Finally, the application of GA-AgNPs was validated by determining cartap in rice samples.

show abstract

Bare silver and gold nanospheres: potential role as nanosensors for selective detection of L-carnosine and monothioglycerol

Kumar,

Rayavarapu

2024

emergent mater.

View full text Add to dashboard Cite

Tailored silver nanoparticles capped with gallic acid and its potential toxicity via ROS mediated pathway against osteosarcoma cells

Cited by 6 publications

References 55 publications

Facile and Green Fabrication of Highly Competent Surface-Modified Chlorogenic Acid Silver Nanoparticles: Characterization and Antioxidant and Cancer Chemopreventive Potential

Facile and Green Fabrication of Highly Competent Surface-Modified Chlorogenic Acid Silver Nanoparticles: Characterization and Antioxidant and Cancer Chemopreventive Potential

Ag Nanoparticles Decorated by Gallic Acid as a Colorimetric Sensor for the Detection of Cartap Pesticide

Bare silver and gold nanospheres: potential role as nanosensors for selective detection of L-carnosine and monothioglycerol

Contact Info

Product

Resources

About