Tailoring copper(ii) complexes with pyridine-4,5-dicarboxylate esters for anti-Candida activity

Abstract

Antifungal copper(ii) complexes with pyridine-4,5-dicarboxylate esters show the ability to inhibit the filamentation and biofilm formation of Candida albicans, and efficiently prevent the adhesion of this fungus.

Advances in Antifungal Drug Development: An Up-To-Date Mini Review

“…Another example is reported by Stevanovic et al, who showed that a fluconazole zinc (II) complex had significantly better antifungal activity against Candida krusei and Candida parapsilosis than fluconazole [52]. Other new metal coordinates, not complexed with known antifungals, are at preclinical stages [53,54]. On the other hand, Polvi and colleagues screened a library of pharmacologically active compounds that do not themselves possess antifungal activity as an attempt to identify compounds that can potentiate the efficacy of caspofungin against echinocandin-resistant Candida albicans strains.…”

Copper(ii) and silver(i) complexes with dimethyl 6-(pyrazine-2-yl)pyridine-3,4-dicarboxylate (py-2pz): the influence of the metal ion on the antimicrobial potential of the complex

“…23 On the other hand, no antibacterial effect was observed for five copper( ii ) complexes with pyridine-4,5-dicarboxylate esters, while two of them, namely [Cu(NO 3 ) 2 (py-2metz)(H 2 O)] and [CuCl 2 (py-2metz)] n (py-2metz is dimethyl 2-(4-methylthiazol-2-yl)pyridine-4,5-dicarboxylate), have shown a moderate antifungal activity with a minimal inhibitory concentration (MIC) of 31.25 μg mL −1 against C. albicans . 24 Similarly, none of the five copper( ii ) complexes with aromatic nitrogen-containing heterocycles (N-heterocycles), e.g. pyrimidine, pyrazine, quinazoline and phthalazine, manifested significant antimicrobial activity against the investigated bacterial and Candida strains.…”

“…Moreover, py-2pz was chosen as a versatile ligand which can behave both as bridging and chelating bidentate ligand (Scheme 1). Structurally similar ligands such as derivatives of different pyridine-4,5-dicarboxylate esters, dimethyl 2-(thiazol-2-yl)pyridine-4,5-dicarboxylate (py-2tz), dimethyl 2-(4-methylthiazol-2-yl)pyridine-4,5-dicarboxylate (py-2metz) and dimethyl 2,2′-bipyridine-4,5-dicarboxylate (py-2py), were previously used for the synthesis of silver( i ) complexes, which have shown the significant activity against cow mastitis associated pathogens, 37 of ruthenium( ii ) complexes as inhibitors of aldo-keto reductases 38 and 15-lipoxygenase-1, 39 and of the abovementioned copper( ii ) complexes, 24 as well as antifungal zinc( ii ) complex. 40 The antimicrobial activity of the synthesized complexes 1–4 were evaluated against two bacterial ( P. aeruginosa and S. aureus ) and two Candida ( C. albicans and C. parapsilosis ) species, as well as their toxicity on the human normal fibroblast cell line (MRC-5).…”

New Volatile Perfluorinated Amidine–Carboxylate Copper(II) Complexes as Promising Precursors in CVD and FEBID Methods

“…Nowadays, copper compounds are used, for example, to design hybrid organicinorganic materials [1][2][3], anticancer agents [4,5], and sensors [6,7]. Additionally, copper complexes are used as model compounds and tested as antimicrobial agents [8][9][10].…”