Tailoring Cu substituted hydroxyapatite/functionalized multiwalled carbon nanotube composite coating on 316L SS implant for enhanced corrosion resistance, antibacterial and bioactive properties

Sivaraj, D.; Vijayalakshmi, K.; Arumugam, G; Rajendran, R.

doi:10.1016/j.ijpharm.2020.119946

Cited by 36 publications

(28 citation statements)

References 60 publications

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“…According to the XPS results, the main compounds in the coating are Cu(OH) 2 and CuHPO 4 , which have low solubility. The results show that the quantity of Cu 2+ release is 0.157 mg/L, which is higher than that of the HA coatings prepared by D. Sivaraj et al (0.042 mg/L), 7) but lower than that of the HA powders prepared by S. Gomes et al (at least 0.4 mg/L). 15) It has been reported that Cu 2+ can destroy the cell wall of E. coli, enter the cell membrane, inhibit the transport and metabolism of sugar, lead to the destruction of metal ion homeostasis and enzyme system, and finally kill E. coli.…”

Section: Antibacterial Activitycontrasting

confidence: 52%

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Antibacterial Cu-Doped Calcium Phosphate Coating on Pure Titanium

Junchao

et al. 2021

Mater. Trans.

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Cu-doped amorphous calcium phosphate (ACP) coatings were fabricated on the surface of pure titanium (Ti) by electrochemical deposition at initial electrolyte temperatures of 35, 45, and 55°C. The antibacterial activities of the coatings were then evaluated by the plate counting method using Escherichia coli as the indicator. The Cu concentrations on the surfaces of samples are increased from 6.90 to 15.05 mass% as initial electrolyte temperature is increased from 35 to 55°C. The Cu-doped ACP coatings show that they can fully inhibit the growth of E. coli.

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Section: Antibacterial Activitycontrasting

confidence: 52%

“…6) Compared with HA, ACP particles can also destroy the stability of bacterial cell membrane and inhibit the growth of bacteria. 7) In this study, Cu-doped antibacterial amorphous coatings were electrochemically deposited on Ti substrates via Cucontaining CaP solutions at different initial temperatures.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Cu-Doped Calcium Phosphate Coating on Pure Titanium

Junchao

et al. 2021

Mater. Trans.

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“…However, the shortcomings of HA coating, such as high brittleness and low strength, make it difficult to be applied to the load-bearing parts. In order to improve these shortcomings, HA biological composite coating is usually used [ 8 , 9 , 10 , 11 ]. HA coating on the surface of Mg alloys is evaluated in the following four ways: First, the in vitro degradation of the coating samples is determined by electrochemical experiments and in vitro immersion, which provides a reference for the practical application of the coating.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances on Development of Hydroxyapatite Coating on Biodegradable Magnesium Alloys: A Review

et al. 2021

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The wide application of magnesium alloys as biodegradable implant materials is limited because of their fast degradation rate. Hydroxyapatite (HA) coating can reduce the degradation rate of Mg alloys and improve the biological activity of Mg alloys, and has the ability of bone induction and bone conduction. The preparation of HA coating on the surface of degradable Mg alloys can improve the existing problems, to a certain extent. This paper reviewed different preparation methods of HA coatings on biodegradable Mg alloys, and their effects on magnesium alloys’ degradation, biocompatibility, and osteogenic properties. However, no coating prepared can meet the above requirements. There was a lack of systematic research on the degradation of coating samples in vivo, and the osteogenic performance. Therefore, future research can focus on combining existing coating preparation technology and complementary advantages to develop new coating preparation techniques, to obtain more balanced coatings. Second, further study on the metabolic mechanism of HA-coated Mg alloys in vivo can help to predict its degradation behavior, and finally achieve controllable degradation, and further promote the study of the osteogenic effect of HA-coated Mg alloys in vivo.

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“…Cu-substituted HAp/MWCNT-coated 316L SS implants were developed, and the biological advantages were assessed. The results suggest that a cytocompatible concentration should be considered to not induce cytotoxicity and hemolysis [ 95 ]. The osteogenic potential of HAp/MWCNT was elucidated.…”

Section: Cnms For Dental Applicationmentioning

confidence: 99%

Potential of Carbon-Based Nanocomposites for Dental Tissue Engineering and Regeneration

et al. 2021

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While conventional dental implants focus on mechanical properties, recent advances in functional carbon nanomaterials (CNMs) accelerated the facilitation of functionalities including osteoinduction, osteoconduction, and osseointegration. The surface functionalization with CNMs in dental implants has emerged as a novel strategy for reinforcement and as a bioactive cue due to their potential for mechanical reinforcing, osseointegration, and antimicrobial properties. Numerous developments in the fabrication and biological studies of CNMs have provided various opportunities to expand their application to dental regeneration and restoration. In this review, we discuss the advances in novel dental implants with CNMs in terms of tissue engineering, including material combination, coating strategies, and biofunctionalities. We present a brief overview of recent findings and progression in the research to show the promising aspect of CNMs for dental implant application. In conclusion, it is shown that further development of surface functionalization with CNMs may provide innovative results with clinical potential for improved osseointegration after implantation.

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Tailoring Cu substituted hydroxyapatite/functionalized multiwalled carbon nanotube composite coating on 316L SS implant for enhanced corrosion resistance, antibacterial and bioactive properties

Cited by 36 publications

References 60 publications

Antibacterial Cu-Doped Calcium Phosphate Coating on Pure Titanium

Antibacterial Cu-Doped Calcium Phosphate Coating on Pure Titanium

Recent Advances on Development of Hydroxyapatite Coating on Biodegradable Magnesium Alloys: A Review

Potential of Carbon-Based Nanocomposites for Dental Tissue Engineering and Regeneration

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