Tailoring doxorubicin sustainable release from biopolymeric smart matrix using congo red as molecular helper

Abstract

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Preparation of Succinoglycan Hydrogel Coordinated With Fe3+ Ions for Controlled Drug Delivery

“…The behavior of Congo red in the solution is similar to aromatic drugs that produce red colloidal fluorescent solutions in an aqueous medium prepared due to the stacking mechanism. Congo red has also been used to detect fibrillar proteins useful for histological studies of some neurodegenerative pathologies such as Alzheimer's, Creutzfeldt-Jakob, Huntington's, and Parkinson's diseases [62]. In this study, we prepared Fe 3+ -SG hydrogel beads by loading Congo red in the succinoglycan solution.…”

Lactoferrin-Loaded Alginate Microparticles to Target Clostridioides difficile Infection

“…Protein-loaded microparticles (10 mg) were dispersed in PBS at pH of 7.4 (100 mL, containing 5% (v/v) ethanol) and stirred continuously for 24 h. UV-Vis spectrophotometry was used to determine the amount of free protein in supernatant via absorption at 450 nm. The protein content and loading efficiency was calculated as described by Bosio et al 2014 12 from experimentally determined calibration curves of protein content with UV absorption.…”

“…As a consequence, alginates are used in a number of pharmaceutical applications, but alginate particles in particular are used to control release of oral delivery of drugs and proteins. 7,8,9,10,11,12,13 Alginate-derived polymers can easily be formulated into controllable diameter microparticles with appropriate size distributions for ingestion (~100 µm). 7 These particles can be prepared by various techniques such as microfluidic fabrication, 14,15,16,17 air atomization, 18,19,20 emulsification/internal gelation, 21 complexation with counterion polymers, 22 spray-drying, 23 impinging aerosols, 24,25 and inkjet/drying processes.…”

Synthesis and characterization of CaCO 3 –biopolymer hybrid nanoporous microparticles for controlled release of doxorubicin

“…The strategy was to use the hydrophobic aromatic ring of the 26 polar Dox molecule interacting with the planar aromatic ring structure of the CR, a phenomenon 27 commonly described as Π-Π stacking. The results showed that the amount of CR was able to 28 control Dox loading into the matrix and also the kinetics of drug release [19]. In the present work, 29 the approach was to encapsulate Dox in a matrix but using the opposite strategy: hydrophilic 30 interactions.…”

“…In our previous work, the development and characterization of biogel microbeads composed of 24 alginate and carboxymethylated guar gum to encapsulate Dox in the presence of Congo Red as a 25 molecular helper was analyzed [19]. The strategy was to use the hydrophobic aromatic ring of the 26 polar Dox molecule interacting with the planar aromatic ring structure of the CR, a phenomenon 27 commonly described as Π-Π stacking.…”