Tailoring Functional Interlayers in Organic Field‐Effect Transistor Biosensors

Abstract

This review aims to provide an update on the development involving dielectric/organic semiconductor (OSC) interfaces for the realization of biofunctional organic field-effect transistors (OFETs). Specific focus is given on biointerfaces and recent technological approaches where biological materials serve as interlayers in back-gated OFETs for biosensing applications. Initially, to better understand the effects produced by the presence of biomolecules deposited at the dielectric/OSC interfacial region, the tuning of the dielectric surface properties by means of self-assembled monolayers is discussed. Afterward, emphasis is given to the modification of solid-state dielectric surfaces, in particular inorganic dielectrics, with biological molecules such as peptides and proteins. Special attention is paid on how the presence of an interlayer of biomolecules and bioreceptors underneath the OSC impacts on the charge transport and sensing performance of the device. Moreover, naturally occurring materials, such as carbohydrates and DNA, used directly as bulk gating materials in OFETs are reviewed. The role of metal contact/OSC interface in the overall performance of OFET-based sensors is also discussed.

Organic bioelectronics probing conformational changes in surface confined proteins

“…This has been achieved by means of the the electrochemical transistors40 and the electrolyte gated TFT41. Moreover, very sensitive determinations become possible when the direct interfacing of a biological recognition layer with a transistor electronic channel is exploited42. This has been achieved with the functional bio-interlayer thin film transistors (FBI-OTFTs)43, whose detection limits have been proved to reach the pM range.…”

DNA as Functional Material in Organic-Based Electronics

“…Moreover, DNA can be even used in color-tunable OLEDs, which are of great importance for the good control of pixels in large-screen based display with enhanced resolution and color quality. Kobayashi et al [48] developed the DNA/Pan/Ru(bpy) 3 2+ based color tunable…”

“…In recent years, with the development of electronic information technology and the massive use of plastic electronics, the materials waste problem has become increasingly serious, and plastic consumption and wastes have already been one of the major concerns in the world nowadays, especially in developing countries [1][2][3]. Therefore, it is essential to develop and investigate potential bio-degradable, bio-compatible, bioresorbable, or even metabolizable devices, which serve as the components of various electronic and photonic products.…”

Druckbare Bioelektronik zur Untersuchung funktioneller biologischer Grenzflächen

“…[18] Diese Systeme basieren auf organischen oder druckbaren bioelektronischen Tr ansistorstrukturen (hauptsächlich TFTs [19] ,aber auch Feldeffekttransistoren, FETs), [20] wobei sie unterschiedliche Konfigurationen und Funktionsprinzipien aufweisen. Wegen ihrer Bedeutung sollten unter anderem elektrochemische Tr ansistoren, [21] elektrolytgesteuerte TFTs, [7a,22] ladungsmodulierte organische FETs [23] und Strukturen mit Back-Gate [24] oder Strukturen mit DoubleGate [25] angeführt werden. Die angegebenen Bauelemente werden gewçhnlich in zwei Hauptkategorien unterteilt:T ransistoren, die einen Ionenleiter enthalten, und Transistoren, bei denen ein Isolator als Dielektrikum genutzt wird.…”