Tailoring morphologies of diamond thin films for neural stem cells culturing

Babchenko, Oleg; Romanyuk, Nataliya; Jendelová, Pavla; Kromka, Alexander

doi:10.1002/pssb.201300082

Cited by 10 publications

(6 citation statements)

References 28 publications

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“…Several articles report on successful culturing of neural cells on nanocrystalline diamond 15,33,40 , ultrananocrystalline diamond 8,41 or nanodiamond treated substrates 42 without any form of additional chemical coating. Results of cultivation of uncoated substrates are summarized in 7 .…”

Section: Effect Of Chemical Treatment: Pei Pdl and The Role Of Lamininmentioning

confidence: 99%

“…There were many studies on evaluating the influence of various parameters of diamond films on neuron interfacing, recently summarized in 7 . The studies focused on the effect of surface termination (hydrogen vs oxygen termination 31 ), level of doping 32 , and surface morphology 1,33 . It is difficult to make general conclusions about the influence of one aspect or the other, as in some cases the results contradict each other.…”

Section: Introductionmentioning

confidence: 99%

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Neuron Adhesion on Diamond: Competition between Polymer Treatment and Surface Morphology

et al. 2018

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The ability to form an efficient interface between material and neural cells is a crucial aspect of the construction of neuroelectrodes. Diamond offers material characteristics that could, by a large extent, improve the performance of neuroelectrodes. The greatest advantage of diamond is a large variety of material and surface properties such as electrical conductivity, surface morphology, and surface chemistry. Such a variety of material characteristics can lead to various cellular responses. Here we compare survival, adhesion, and neurite formation of primary neurons on diamond thin films of various morphology and on their treatment with several types of polymers commonly used to enhance cell adhesion. We found that the variation of surface roughness of nanocrystalline diamond film does not have a major influence on the neuron survival or adhesion. The adhesion of neurons can beinfluenced by the selected type of polymer coating.

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Section: Effect Of Chemical Treatment: Pei Pdl and The Role Of Lamininmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neuron Adhesion on Diamond: Competition between Polymer Treatment and Surface Morphology

et al. 2018

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“…Thus, neurons have been patterned by contact micro-printing [29] as shown in figure 6, inkjet and laser patterning [24], selective seeding of NDPs [43] and diamond deposition on patterned carbon nanotubes [14]. Further studies showed that neuronal growth on various diamond and DLC substrates can be manipulated by a combination of laminin coating and surface termination [125][126][127]. Similarly, neuroblastoma cells have also been preferentially grown on UNCD patterned with O, F or H terminations, and this may lead to new routes to studying neuronal cancer [128].…”

Section: Diamond For Brain Researchmentioning

confidence: 99%

Diamond thin films: giving biomedical applications a new shine

Nistor

May

2017

J. R. Soc. Interface.

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Progress made in the last two decades in chemical vapour deposition technology has enabled the production of inexpensive, high-quality coatings made from diamond to become a scientific and commercial reality. Two properties of diamond make it a highly desirable candidate material for biomedical applications: first, it is bioinert, meaning that there is minimal immune response when diamond is implanted into the body, and second, its electrical conductivity can be altered in a controlled manner, from insulating to near-metallic. In vitro, diamond can be used as a substrate upon which a range of biological cells can be cultured. In vivo, diamond thin films have been proposed as coatings for implants and prostheses. Here, we review a large body of data regarding the use of diamond substrates for in vitro cell culture. We also detail more recent work exploring diamond-coated implants with the main targets being bone and neural tissue. We conclude that diamond emerges as one of the major new biomaterials of the twenty-first century that could shape the way medical treatment will be performed, especially when invasive procedures are required.

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“…Thus, concerning the property of the material that can improve cell adhesion, it is worth considering the advantages of using functionalization of the substrate. H-, O-, and NH 2 -terminations of UNCD films have been shown to provide excellent substrates for insect circadian pacemaker neurons in comparison to untreated surfaces, while human fetal neural stem cells SPC-01 preferentially attach to the O- rather than to the H-terminated NCD surfaces. , In addition, adhesion of neuroblastoma cells or primary cortical neurons to DLC surfaces can be optimized using phosphorus-doped diamond-like carbon (P-DLC), rather than O-DLC termination or undoped DLC …”

Section: Interfacing Neurons With Dbms To Detect Action Potential Firingmentioning

confidence: 99%

“…H-, O-, and NH 2terminations of UNCD films have been shown to provide excellent substrates for insect circadian pacemaker neurons in comparison to untreated surfaces, while human fetal neural stem cells SPC-01 preferentially attach to the O-rather than to the H-terminated NCD surfaces. 97,98 In addition, adhesion of neuroblastoma cells or primary cortical neurons to DLC surfaces can be optimized using phosphorus-doped diamondlike carbon (P-DLC), rather than O-DLC termination or undoped DLC. 99 The roughness of the substrate may be also a relevant parameter.…”

Section: Acs Chemical Neurosciencementioning

confidence: 99%

Planar Diamond-Based Multiarrays to Monitor Neurotransmitter Release and Action Potential Firing: New Perspectives in Cellular Neuroscience

Carabelli

Marcantoni

Picollo

et al. 2017

ACS Chem. Neurosci.

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High biocompatibility, outstanding electrochemical responsiveness, inertness, and transparency make diamond-based multiarrays (DBMs) first-rate biosensors for in vitro detection of electrochemical and electrical signals from excitable cells together, with potential for in vivo applications as neural interfaces and prostheses. Here, we will review the electrochemical and physical properties of various DBMs and how these devices have been employed for recording released neurotransmitter molecules and all-or-none action potentials from living cells. Specifically, we will overview how DBMs can resolve localized exocytotic events from subcellular compartments using high-density microelectrode arrays (MEAs), or monitoring oxidizable neurotransmitter release from populations of cells in culture and tissue slices using low-density MEAs. Interfacing DBMs with excitable cells is currently leading to the promising opportunity of recording electrical signals as well as creating neuronal interfaces through the same device. Given the recent increasingly growing development of newly available DBMs of various geometries to monitor electrical activity and neurotransmitter release in a variety of excitable and neuronal tissues, the discussion will be limited to planar DBMs.

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Tailoring morphologies of diamond thin films for neural stem cells culturing

Cited by 10 publications

References 28 publications

Neuron Adhesion on Diamond: Competition between Polymer Treatment and Surface Morphology

Neuron Adhesion on Diamond: Competition between Polymer Treatment and Surface Morphology

Diamond thin films: giving biomedical applications a new shine

Planar Diamond-Based Multiarrays to Monitor Neurotransmitter Release and Action Potential Firing: New Perspectives in Cellular Neuroscience

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