Tailoring the morphological features of sol–gel synthesized mesoporous hydroxyapatite using fatty acids as an organic modifier

Lett, J. Anita; Sundareswari, M.; Ravichandran, K.; Muthiah, Bavanilatha; Sagadevan, Suresh; Johan, Mohd Rafie

doi:10.1039/c9ra00051h

Cited by 43 publications

(23 citation statements)

References 48 publications

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“…The weak absorption bands at 1408, 1456 cm −1 were observed for samples HAP and HAP-LA as reported for carbonated HAP, which could result from the presence of atmospheric carbon dioxide during calcination processes [30,31]. The presence of TCP is also shown by the stretching frequency of the phosphate group at 2360 cm -1 [15] for the HAP and HAP-LA samples. Furthermore, the existence of TCP is also weakened, which is in coincidence with the XRD results.…”

Section: Resultssupporting

confidence: 64%

“…The fatty acids play an important role in shape-controlled synthesis by allowing simplistic separation between nucleation and growth stages. The surfactant's role in defining morphology requires a clear indication of its ability to follow specific crystal faces and direct growth of crystals [15].The literature effectively proved the use of oleic acid as a surfactant; however, it continues unknown how it could cause healing of the bone fracture. Polycaprolactone (PCL)/Osteoarthritis (OA) scaffolds were manufactured using mixed methods to test the theory that fatty acid is a bone induction factor: solvent casting and particulate leaching [16].…”

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confidence: 99%

“…Structural, functional, and morphological characterization was studied to the as-prepared HAP particles. Mesoporous in HAP were noted by removing the organic template for samples synthesized at pH 11 [15]. Therefore, the aim of this present work is to compare the structural and morphological characteristics of HAP synthesized using lauric acid (LA) and stearic acid (SA) as an organic modifier.…”

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confidence: 99%

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Drug Leaching Properties of Vancomycin Loaded Mesoporous Hydroxyapatite as Bone Substitutes

et al. 2019

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Infections after bone reconstructive surgery become an authentic therapeutic and economic issue when it comes to a modern health care system. In general; infected bone defects are regarded as contraindications for bone grafting. Since the pathogens develop a biofilm on the inner surface of the bone; local delivery of antibiotics becomes more important. The present work focuses on the synthesis of Mesoporous Hydroxyapatite (MPHAP) loaded with drug Vancomycin (Van) and to investigate its loading and leaching ability in phosphate buffer solution (PBS), to be used for post-operative infections. The effect of pore size on MPHAP was analyzed using different fatty acids as organic modifiers. The impacts of various fatty acids chain length on the morphology and pore size were studied. A simple impregnation technique with optimized conditions ensured a high antibiotic loading (up to 0.476 + 0.0135 mg/mL), with a complete in vitro release obtained within 50 h.

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confidence: 64%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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Drug Leaching Properties of Vancomycin Loaded Mesoporous Hydroxyapatite as Bone Substitutes

et al. 2019

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“…Laghzizil et al [22] have correlated the results of HaP fluorination with the physicochemical properties of HaP. Recently, morphological modifications of hydroxyapatite using fatty acids as an organic modifier have been reported [23]. The goal of this work is the successful…”

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confidence: 92%

HaP/SBA-3 Nanostructured Composite to Remove Fluoride Effectively from Contaminated Water

Anunziata¹

2021

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Highly ordered pore mesoporous silica composites, like SBA-3 and hydroxyapatite (HaP) nanocrystals, characterized by X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM) and textural properties, were successfully applied to remove fluoride from contaminated water. The proposed procedure to prepare HaP/SBA-3 was successful, which acts as supports to anchor the HaP crystals, in nanometer-scale (<2nm), with higher fluoride retention from contaminated water. The free OH-groups of HaP nanocrystals, within the host, facilitated the high-performance fluoride trapping. The fluoride retention activity was much higher than that of pure HaP and the composites HaP/SBA-15 and HaP/MCM-41.

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Influence of pH in the synthesis of calcium phosphate based nanostructures with enhanced bioactivity and pro‐angiogenic properties

2022

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In synthetic fabrication, the process parameters decide the growth nucleation, phase translation, and the evolution of morphological facets of nanostructured materials. This work demonstrates the formation of different crystallographic phases of calcium phosphate by the influence of pH from acidic to alkaline conditions and also investigated their bone regeneration, protein adsorption, and pro‐angiogenic properties. Present results illustrate that the alteration of pH is the crucial factor for the synthesis of calcium phosphate (CP) phases. The structural analysis reveals the monetite (CaHPO4) phase with a triclinic crystal system for pH 5, dual‐phase of monetite combined with hydroxyapatite at the neutral pH 7, and pure phase of hydroxyapatite (Ca10[PO4]6OH2) with hexagonal structure at pH 10. Microscopic analysis portrays the cubic and rod‐like morphologies by changing the pH values. FTIR and RAMAN spectroscopic analyses confirm the stretching, bending, and vibrational modes of dominant phosphate groups of different CP phases. Further, the biocompatibility of the prepared CP phases was examined by hemolysis assay, which showed less than 2% of lysis and enhanced cell viability. Moreover, the bioactivity study revealed rapid mineralization and a higher protein adsorption rate for the monetite CP phase (M‐CP). Subsequently, the chick embryo angiogenesis assay elucidated 33% higher neovascularization for M‐CP compared with the other two CP phases. The fabricated M‐CP nanostructure constitutes a promising candidate for biomedical applications.

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Tailoring the morphological features of sol–gel synthesized mesoporous hydroxyapatite using fatty acids as an organic modifier

Abstract: Nowadays, owing to their large surface area, enhanced pore volume, increased porosity, and variable pore size, mesoporous materials, such as mesoporous silica and mesoporous carbon, have attracted significant attention in the areas of physical science and biomedical sciences.

Cited by 43 publications

References 48 publications

Drug Leaching Properties of Vancomycin Loaded Mesoporous Hydroxyapatite as Bone Substitutes

Drug Leaching Properties of Vancomycin Loaded Mesoporous Hydroxyapatite as Bone Substitutes

HaP/SBA-3 Nanostructured Composite to Remove Fluoride Effectively from Contaminated Water

Influence of pH in the synthesis of calcium phosphate based nanostructures with enhanced bioactivity and pro‐angiogenic properties

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