Tailoring the morphology and rheology of phase-separated biopolymer gels using microbial cells as structure modifiers

Firoozmand, Hassan; Rousseau, Dérick

doi:10.1016/j.foodhyd.2014.04.040

Cited by 46 publications

(26 citation statements)

References 57 publications

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“…The present results suggest a combination of different stabilization mechanisms, including the presence of mono-and multilayers as well as the possibility of localized inter-particle repulsion given the negative zeta potential values of ca. -15 mV (Firoozmand & Rousseau, 2014).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Microbial cells as colloidal particles: Pickering oil-in-water emulsions stabilized by bacteria and yeast

Firoozmand

Rousseau

2016

Food Research International

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Section: Accepted Manuscriptmentioning

confidence: 99%

Microbial cells as colloidal particles: Pickering oil-in-water emulsions stabilized by bacteria and yeast

Firoozmand

Rousseau

2016

Food Research International

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“…While many of the main applications of this technique are largely focused on extraction and purification of material such as DNA [65,66], proteins [67][68][69], and metals [70], the opportunities are significant for producing microstructured hydrogel materials with biomedical applications such as drug delivery and tissue regeneration [71][72][73] or even to form synthetic membraneless organelles for modeling intracellular processes [74]. Limitations of LLPS include a loss of temporal control over the microstructure due to rapid phase separation [73,75], and biocompatible approaches to overcome this issue have been based mainly on interface stabilization by copolymers [76] and Pickering particles [77]. Besides interfacial stabilizers, there are a wide variety of chemical reactions used in hydrogel crosslinking that can arrest the phase separation, with the already mentioned Michael-type addition and photocrosslinking reactions as particularly useful options due to their fast reaction kinetics [78,79].…”

Section: Introductionmentioning

confidence: 99%

Methods for producing microstructured hydrogels for targeted applications in biology

Garcia

Kiick

2019

Acta Biomaterialia

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Hydrogels have been broadly studied for applications in clinically motivated fields such as tissue regeneration, drug delivery, and wound healing, as well as in a wide variety of consumer and industry uses. While the control of mechanical properties and network structures are important in all of these applications, for regenerative medicine applications in particular, matching the chemical, topographical and mechanical properties for the target use/tissue is critical. There have been multiple alternatives developed for fabricating materials with microstructures with goals of controlling the spatial location, phenotypic evolution, and signaling of cells. The commonly employed polymers such as poly(ethylene glycol) (PEG), polypeptides, and polysaccharides (as well as others) can be processed by various methods in order to control material heterogeneity and microscale structures. We review here the more commonly used polymers, chemistries, and methods for generating microstructures in biomaterials, highlighting the range of possible morphologies that can be produced, and the limitations of each method. With a focus in liquidliquid phase separation, methods and chemistries well suited for stabilizing the interface and arresting the phase separation are covered. As the microstructures can affect cell behavior, examples of such effects are reviewed as well.

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“…The addition of these organisms to phase-separated solutions of gelatin + maltodextrin altered the developing microstructure and rheological properties of the gels (Firoozmand and Rousseau, 2014). The addition of these organisms to phase-separated solutions of gelatin + maltodextrin altered the developing microstructure and rheological properties of the gels (Firoozmand and Rousseau, 2014).…”

Section: Using Nonviable Edible Single-celled Organisms As Particlesmentioning

confidence: 99%

Controlled phase separation for texture modification

Firoozmand

Rousseau

2015

Modifying Food Texture

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Tailoring the morphology and rheology of phase-separated biopolymer gels using microbial cells as structure modifiers

Cited by 46 publications

References 57 publications

Microbial cells as colloidal particles: Pickering oil-in-water emulsions stabilized by bacteria and yeast

Microbial cells as colloidal particles: Pickering oil-in-water emulsions stabilized by bacteria and yeast

Methods for producing microstructured hydrogels for targeted applications in biology

Controlled phase separation for texture modification

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