2017
DOI: 10.1016/j.jcou.2017.04.015
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Tailoring the particle microstructures of gefitinib by supercritical CO 2 anti-solvent process

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Cited by 33 publications
(15 citation statements)
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“…This saturated solubility increasingly inhibits supersaturation during crystallization; thus, it is not conducive for producing small sulfasalazine crystals. [16,27,29]. In addition, the CO2 flowrate and solution flowrate had considerable influence on the crystal habit of recrystallized sulfasalazine.…”
Section: Resultsmentioning
confidence: 99%
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“…This saturated solubility increasingly inhibits supersaturation during crystallization; thus, it is not conducive for producing small sulfasalazine crystals. [16,27,29]. In addition, the CO2 flowrate and solution flowrate had considerable influence on the crystal habit of recrystallized sulfasalazine.…”
Section: Resultsmentioning
confidence: 99%
“…9 (1.03 μm). [16,27,29]. In addition, the CO 2 flowrate and solution flowrate had considerable influence on the crystal habit of recrystallized sulfasalazine.…”
Section: Resultsmentioning
confidence: 99%
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“…. The operating details can be found in our previous work . Briefly, equimolar (1:1 mole ratio) quantities of PCA and TMG were dissolved in 50 mL of DCM and MeOH, then mixed at 40 °C under sonication for 10 min to obtain a clear solution.…”
Section: Methodsmentioning
confidence: 99%
“…Whereas, the disadvantages of SAS technique is the longer time for washing due to aggregation/agglomeration of the particles in the nozzle/atomizer [1]. There have been several research studies that used SAS method to produce fine particles [3,[23][24]. Figure 7 shows the schematic diagram of GAS process.…”
Section: Supercritical Anti-solvent (Sas) -Gas Ases Sedsmentioning
confidence: 99%