Tailoring the plasmonic properties of gold-liposome nanohybrids as a potential powerful tool for light-mediated therapies

Rubio-Camacho, Marta; Martínez-Tomé, María José; Cuestas-Ayllon, Carlos; Fuente, Jesús M. de la; Esquembre, Rocío; Mateo, C. Reyes

doi:10.1016/j.colcom.2022.100690

Cited by 5 publications

(4 citation statements)

References 37 publications

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“…The fabrication of AuNP-liposome nanocomposites should bring the best of both: (1) excellent drug loading into the liposomes and (2) light responsiveness which can trigger the release of loaded therapeutics. Excellent examples are reported in the literature using various types of liposomes and AuNP [123,124,[186][187][188]. This approach was first reported in 2007 by Lauri and co-workers who encapsulated hydrophilic and hydrophobic AuNP into the lipid bilayer or the aqueous reservoir of liposomes, respectively [124].…”

Section: Phototherapy and Laser-triggered Drug Deliverymentioning

confidence: 99%

The Golden Liposomes: Preparation and Biomedical Applications of Gold-Liposome Nanocomposites

Idoudi

Ismail

Rachid

et al. 2023

JNT

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Gold nanoparticles (AuNP) have received a growing attention due to their fascinating physiochemical properties and promising range of biomedical applications including sensing, diagnosis and cancer photothermal ablation. AuNP enjoy brilliant optical properties and ability to convert light into local heat and function as a “nanoheaters” to fight cancer. However, AuNP are poor drug delivery systems as they do not have reservoirs or matrices to achieve an acceptable drug loading efficiency. On the other end, liposome-based nanocarriers do not exhibit such optical properties but are excellent platform for drug loading and they have been proven clinically with a true presence in the market since the FDA approved Doxil® in 1995. Combining the brilliant optical and photothermal properties of AuNP with the excellent drug loading capability of liposome should yield nanocomposites that enjoy the features of both modalities and enable the development of novel and smart drug delivery systems. Therefore, this review discusses the up-to date research on the AuNP-liposome nanocomposites and the current available approaches and protocols for their preparation and characterization. Finally, the biomedical applications of AuNP-liposome nanocomposites and proposed future directions in this field are discussed.

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Section: Phototherapy and Laser-triggered Drug Deliverymentioning

confidence: 99%

The Golden Liposomes: Preparation and Biomedical Applications of Gold-Liposome Nanocomposites

Idoudi

Ismail

Rachid

et al. 2023

JNT

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“…Interestingly, Rubio-Camacho et al [104] synthesized stable gold nanoparticles on the surface of DPPC thermosensitive liposomes, termed AuNPs@DPPC, resulting in the formation of nanohybrids with an on-demand plasmon mode in the visible/NIR region and with good photothermal conversion efficiency. The AuNPs@DPPC nanohybrids retained the physical properties of DPPC thermosensitive liposomes without altering either the liposome fluidity or the hydration degree of the lipid bilayer.…”

Section: Surface Plasmon Resonance Absorption (Photothermal Activation)mentioning

confidence: 99%

Light-Responsive and Dual-Targeting Liposomes: From Mechanisms to Targeting Strategies

Agiba,

Arreola-Ramírez,

Carbajal

et al. 2024

Molecules

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In recent years, nanocarriers have played an ever-increasing role in clinical and biomedical applications owing to their unique physicochemical properties and surface functionalities. Lately, much effort has been directed towards the development of smart, stimuli-responsive nanocarriers that are capable of releasing their cargos in response to specific stimuli. These intelligent-responsive nanocarriers can be further surface-functionalized so as to achieve active tumor targeting in a sequential manner, which can be simply modulated by the stimuli. By applying this methodological approach, these intelligent-responsive nanocarriers can be directed to different target-specific organs, tissues, or cells and exhibit on-demand controlled drug release that may enhance therapeutic effectiveness and reduce systemic toxicity. Light, an external stimulus, is one of the most promising triggers for use in nanomedicine to stimulate on-demand drug release from nanocarriers. Light-triggered drug release can be achieved through light irradiation at different wavelengths, either in the UV, visible, or even NIR region, depending on the photophysical properties of the photo-responsive molecule embedded in the nanocarrier system, the structural characteristics, and the material composition of the nanocarrier system. In this review, we highlighted the emerging functional role of light in nanocarriers, with an emphasis on light-responsive liposomes and dual-targeted stimuli-responsive liposomes. Moreover, we provided the most up-to-date photo-triggered targeting strategies and mechanisms of light-triggered drug release from liposomes and NIR-responsive nanocarriers. Lastly, we addressed the current challenges, advances, and future perspectives for the deployment of light-responsive liposomes in targeted drug delivery and therapy.

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“…Interestingly, Rubio-Camacho et al [82] synthesized stable gold nanoparticles on the surface of DPPC thermosensitive liposomes, termed AuNPs@DPPC, resulting in the formation of nanohybrids with on-demand plasmon mode in the visible/NIR region and with good photothermal conversion efficiency. The AuNPs@DPPC nanohybrids retained the physical properties of DPPC thermosensitive liposomes without altering either the liposome fluidity or the hydration degree of the lipid bilayer.…”

Section: Surface Plasmon Resonance Absorption (Photothermal Activation)mentioning

confidence: 99%

Light-Responsive and Dual-Targeting Liposomes: From Mechanisms to Targeting Strategies

Segura-Medina,

Agiba,

Arreola-Ramirez

et al. 2023

Preprint

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Over recent years, nanocarriers have played an ever-increasing role in clinical and biomedical applications owing to their unique physicochemical properties and surface functionalities. Lately, much effort has been directed towards the development of smart, stimuli-responsive nanocarriers that are capable of releasing their cargos in response to specific stimulus. These intelligent-responsive nanocarriers can be further surface-functionalized so as to achieve active tumor targeting in a sequential manner, which can be simply modulated by the stimuli. By applying this methodological approach, these intelligent-responsive nanocarriers can be directed to different target-specific organs, tissues or cells, and exhibit on-demand controlled drug release that may enhance therapeutic effectiveness and reduce systemic toxicity. Light, an external stimulus, is one of the most promising triggers for use in nanomedicine to stimulate on-demand drug release from nanocarriers. Light-triggered drug release can be achieved by light irradiation at different wavelengths, either in UV, visible or even NIR region, depending on the photophysical properties of the photo-responsive molecule embedded in the nanocarrier system, the structural characteristics and material composition of the nanocarrier system. In this review, we highlighted the emerging functional role of light in nanocarriers, with emphasis on light-responsive liposomes and dual-targeted stimuli-responsive liposomes. Moreover, we provided the up-to-date phototriggered targeting strategies and mechanisms of light-triggered drug release from liposomes and NIR-responsive nanocarriers. Lastly, we addressed the current challenges, advances, and future perspectives for the deployment of light-responsive liposomes in targeted drug delivery and therapy.

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Tailoring the plasmonic properties of gold-liposome nanohybrids as a potential powerful tool for light-mediated therapies

Cited by 5 publications

References 37 publications

The Golden Liposomes: Preparation and Biomedical Applications of Gold-Liposome Nanocomposites

The Golden Liposomes: Preparation and Biomedical Applications of Gold-Liposome Nanocomposites

Light-Responsive and Dual-Targeting Liposomes: From Mechanisms to Targeting Strategies

Light-Responsive and Dual-Targeting Liposomes: From Mechanisms to Targeting Strategies

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