Tailoring the properties of chitosan-poly(acrylic acid) based hydrogels by hydrophobic monomer incorporation

Rusu, Alina Gabriela; Popa, Marcel; Ibănescu, Constanţa; Danu, Maricel; Vereştiuc, Liliana

doi:10.1016/j.matlet.2015.10.164

Cited by 13 publications

(4 citation statements)

References 18 publications

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“…Cs derivative (MAC5) was synthesized according to a procedure previously reported. , Shortly, functionalization of Cs with MA was carried out in acetic acid solution (5%) using a molar ratio of 1/5 Cs/MA, process performed under stirring for 18 h at room temperature. The resulted solution was dialyzed and freeze-dried.…”

Section: Materials and Methodsmentioning

confidence: 99%

Chitosan Derivatives in Macromolecular Co-assembly Nanogels with Potential for Biomedical Applications

Rusu¹,

Chiriac²,

Niţă³

et al. 2020

Biomacromolecules

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Maleoyl-chitosan/poly(aspartic acid) nanogels were developed and characterized in order to assess its suitability for biomedical applications. Thus, the physicochemical properties were investigated and correlated with the composition of the new structures. Dynamic light scattering measurements, correlated with transmission electron microscopy images, demonstrated that nanogels size distribution was narrow with average diameter between 186 and 246 nm, and presented positive zeta potential values. The sensitivity of nanogels at pH and temperature was also evaluated. Nanogels loaded with amoxicillin showed a controlled release profile dependent on nanogel content. The formulations loaded with amoxicillin had antibacterial properties, and the cytotoxicity tests indicated good in vivo biocompatibility. In conclusion, the new synthesized polyelectrolyte nanogels, which can provide a stable environment for the encapsulated drugs, can be used as a multifunctional platform for administration of antimicrobial agents from the spectrum of antibiotics that have a very poor biodistribution.

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Section: Materials and Methodsmentioning

confidence: 99%

Chitosan Derivatives in Macromolecular Co-assembly Nanogels with Potential for Biomedical Applications

Rusu¹,

Chiriac²,

Niţă³

et al. 2020

Biomacromolecules

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“…Chemical crosslinking by grafting and synthesis of semi-interpenetrated networks are two methods of preparing chitosan-based hydrogels by association with synthetic polymers. Chitosan can be successfully crosslinked with acrylates by homo- or co-polymerization [ 11 , 78 , 79 ]. The resulting materials exhibit pH-sensitivity and an excellent swelling capacity.…”

Section: Chitosan-based Gel Materialsmentioning

confidence: 99%

Insights on Some Polysaccharide Gel Type Materials and Their Structural Peculiarities

Duceac¹,

Stanciu²,

Nechifor³

et al. 2022

Gels

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Global resources have to be used in responsible ways to ensure the world’s future need for advanced materials. Ecologically friendly functional materials based on biopolymers can be successfully obtained from renewable resources, and the most prominent example is cellulose, the well-known most abundant polysaccharide which is usually isolated from highly available biomass (wood and wooden waste, annual plants, cotton, etc.). Many other polysaccharides originating from various natural resources (plants, insects, algae, bacteria) proved to be valuable and versatile starting biopolymers for a wide array of materials with tunable properties, able to respond to different societal demands. Polysaccharides properties vary depending on various factors (origin, harvesting, storage and transportation, strategy of further modification), but they can be processed into materials with high added value, as in the case of gels. Modern approaches have been employed to prepare (e.g., the use of ionic liquids as “green solvents”) and characterize (NMR and FTIR spectroscopy, X ray diffraction spectrometry, DSC, electronic and atomic force microscopy, optical rotation, circular dichroism, rheological investigations, computer modelling and optimization) polysaccharide gels. In the present paper, some of the most widely used polysaccharide gels will be briefly reviewed with emphasis on their structural peculiarities under various conditions.

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“…Chitosan is a cationic polysaccharide, well known for its biocompatibility, bioresorbability, biodegradability, antimicrobial activity, mucoadhesivity, and non-toxicity [77,78]. This natural polymer is commonly used as bioink because it exhibits a shear-thinning behaviour which is beneficial for extrusion-based 3D printing [79,80].…”

Section: Polymers and Polymer Composites Prepared For 3d (Bio)printingmentioning

confidence: 99%

Trends in 3D Printing Processes for Biomedical Field: Opportunities and Challenges

Ghilan¹,

Chiriac²,

Niţă³

et al. 2020

J Polym Environ

145

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Additive manufacturing (AM) is considered the latest technology that creates breakthrough innovations and addresses complex medical problems. This is clearly demonstrated by the promising results obtained in regenerative medicine, diagnosis, implants, artificial tissues and organs. This paper provides a basic understanding of the fundamentals of 3D/4D printing along with bioprinting processes. We are briefly discussing about the main printing systems including stereolithography, inkjet 3D printing, extrusion, laser-assisted printing, selective laser melting and Poly-Jet printing. The basic requirements for the selection of successful inks based on polymers, polymer blends, and composites are described. Furthermore, the on-going transition from 3D to 4D printing is highlighted with emphasis on the newest applications in the medical area. Also, a glimpse into the future possibilities and benefits provided by machine learning in the additive manufacturing field is emphasized. Machine learning can improve printing efficiency by using generative design and testing in the pre-fabrication stage. Finally, important limitations and prospects are identified. Within the next few years, AM is set to become an important component in patient-specific medical technologies.

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Tailoring the properties of chitosan-poly(acrylic acid) based hydrogels by hydrophobic monomer incorporation

Cited by 13 publications

References 18 publications

Chitosan Derivatives in Macromolecular Co-assembly Nanogels with Potential for Biomedical Applications

Chitosan Derivatives in Macromolecular Co-assembly Nanogels with Potential for Biomedical Applications

Insights on Some Polysaccharide Gel Type Materials and Their Structural Peculiarities

Trends in 3D Printing Processes for Biomedical Field: Opportunities and Challenges

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