Tailoring Zinc Oxide Nanowires for High Performance Amperometric Glucose Sensor

Abstract

ZnO nanowire was tailored both physically and chemically to immobilize the enzyme glucose oxidase (GOD) for construction of a glucose sensor with high performance, which was ascribed to its high specific surface area and high isoelectric point value for efficient immobilization of high concentration of acidic enzymes and the mediating effect by the redox reaction of ZnO nanowires. The apparent Michaelis constants J max , and K M were adjusted in a large scope by tailoring the thickness of the GOD/ZnO nanowire layer and the enzyme load in the nanowired network. Thus, a variety of linear region, sensitivities and reaction rates of the sensor could be easily achieved. Moreover, the glucose sensor showed long term stability with the incorporation of the inorganic zinc oxide nanowire.

One-dimensional ZnO nanostructures: Solution growth and functional properties

“…ZnO is an amphoteric oxide with an isoelectric point value of about 9.5 [54]. Generally speaking, ZnO is expected to crystallize by the hydrolysis of Zn salts in a basic solution that can be formed using strong or weak alkalis.…”

“…Reproduced with permission side surfaces and enhance the vertical growth, such as amines like polyethylenimine (PEI) [18,155,156] and ethylenediamine [67,137]; those that cap onto the basal plane of the ZnO nanostructures and promote lateral growth, such as Cl - [124] and C 3 H 5 O(COO) 3 3− (citrate ions) [150,157,158]. The isoelectric point of ZnO powder is at around pH = 9.5 [54]. The sign of the ZnO surface sites is predominately positive or negative for pH values below or above the isoelectric point, respectively [136].…”

“…ZnO is amphoteric, with a isoelectric point of about 9.5 [54]. The ZnO surface will be functionalized with protons H 3 O + or hydroxyl OH -groups with different ζ potentials, when the pH value is lower or higher than the isoelectric point, respectively.…”

Highly efficient potentiometric glucose biosensor based on functionalized InN quantum dots

“…[20][21][22][23][24][25][26] To summarize, we fabricated a glucose biosensor based on the combination of glucose oxidase and InN QDs. The presented biosensor utilizes the substantial advantages of high surface charge density and low-dimensionality of the InN QDs for highly sensitive and rapid response.…”

Work Function Estimation of Bismuth Doped ZNO Thin Film

“…As far as the future of the semiconductor devices is concerned, ZnO has a major role to play in it as it is versatile and has interesting properties like resistivity control over the range of 10 −3 -10 -5 Ω-cm, transparency in the visible range, high electrochemical stability, direct band gap (3.3 eV), absence of toxicity and abundance in nature [1][2]. Therefore, it can be stated that versatility of ZnO ranges from optical, electrical, piezoelectricity, ferromagnetic to gas sensing properties [3][4][5]. Further, large binding energy of 60 meV as compared to 25 meV of GaN makes ZnO technically efficient approving it for the field of optoelectronic applications.…”