1994
DOI: 10.1210/mend.8.12.7708055
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TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily.

Abstract: Using polymerase chain reaction and two degenerate primers whose designs were based on the two best conserved regions of the DNA-binding domain of the nuclear receptor superfamily, we identified and cloned a novel orphan receptor, named TAK1. The open reading frame of TAK1 encodes a protein of 596 amino acid residues. Based on the modular structure and the presence of a DNA-binding domain containing two zinc fingers TAK1 belongs to the steroid/thyroid hormone receptor superfamily. The amino acid sequence of TA… Show more

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Cited by 41 publications
(41 citation statements)
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“…In situ hybridization experiments using probes specific for TR4 have shown transcripts present in actively proliferating cell populations of the brain and peripheral organs at various times throughout embryogenesis, with more restricted expression in adult animals (16)(17)(18). Peripheral tissue expression of TR4 has been shown to be nearly ubiquitous, yet it is often cell-specific within particular tissues (19). Northern blot analysis of tissue from the adult rat demonstrated significant TR4 expression in the prostate, adrenal gland, spleen, thyroid gland, and pituitary gland (16), whereas expression in the mouse was found to be highest in the testis, kidney, and skeletal muscle (19).…”
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confidence: 99%
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“…In situ hybridization experiments using probes specific for TR4 have shown transcripts present in actively proliferating cell populations of the brain and peripheral organs at various times throughout embryogenesis, with more restricted expression in adult animals (16)(17)(18). Peripheral tissue expression of TR4 has been shown to be nearly ubiquitous, yet it is often cell-specific within particular tissues (19). Northern blot analysis of tissue from the adult rat demonstrated significant TR4 expression in the prostate, adrenal gland, spleen, thyroid gland, and pituitary gland (16), whereas expression in the mouse was found to be highest in the testis, kidney, and skeletal muscle (19).…”
mentioning
confidence: 99%
“…Peripheral tissue expression of TR4 has been shown to be nearly ubiquitous, yet it is often cell-specific within particular tissues (19). Northern blot analysis of tissue from the adult rat demonstrated significant TR4 expression in the prostate, adrenal gland, spleen, thyroid gland, and pituitary gland (16), whereas expression in the mouse was found to be highest in the testis, kidney, and skeletal muscle (19).…”
mentioning
confidence: 99%
“…These findings suggest that these nuclear receptors may play important roles in viral transcription. The detailed mechanisms of how the core promoter is differentially regulated by these nuclear receptors remain unclear.The testicular orphan receptor 4 (TR4) (NR2C2) is an orphan member of the nuclear receptor superfamily (15)(16)(17). This family includes classic steroid hormone receptors, the thyroid hormone receptor, the retinoid receptors, and many nuclear orphan receptors whose physiological ligands have not been identified (18).…”
mentioning
confidence: 99%
“…The testicular orphan receptor 4 (TR4) (NR2C2) is an orphan member of the nuclear receptor superfamily (15)(16)(17). This family includes classic steroid hormone receptors, the thyroid hormone receptor, the retinoid receptors, and many nuclear orphan receptors whose physiological ligands have not been identified (18).…”
mentioning
confidence: 99%
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