Takayasu Arteritis in children and young Indians

Jain, Sanjay; Sharma, Navneet; Singh, Surjit; Bali, Harinder K.; Kumar, Lata; Sharma, Bal Krishan

doi:10.1016/s0167-5273(00)00180-7

Cited by 98 publications

(87 citation statements)

References 11 publications

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“…11,18 However, this pre-diagnosis lag period is reported to be comparatively less pronounced (2.5-11.3 months) in Indian and Turkish cohorts of c-TA patients. 7,19,20 In the chronic phase of the disease, as inflammation progresses, stenoses develop, and features secondary to arterial occlusion become clinically overt.…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Childhood‐onset Takayasu arteritis: an update

et al. 2015

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Childhood-onset Takayasu arteritis (c-TA) is a distinct subset affecting a wide age group, ranging from young infants to adolescents and it differs from adult TA in many aspects. There is scarcity of data on c-TA worldwide. The disease is classified using the European League Against Rheumatism/Pediatric Rheumatology International Trials Organization/Pediatric Rheumatology European Society criteria. The non-specific nature of presenting complaints and lack of appropriate biomarkers delay the early diagnosis of this illness and many children present with complications, which become irreversible once they set in. One of the largest cohorts of 40 children with c-TA from our center reports hypertension as the commonest presenting feature. Systemic symptoms like headache, fever and weight loss are also described. Assessment of disease in c-TA is done by correlating clinical features with raised inflammatory markers. Advanced imaging plays an important role in diagnosis. In c-TA, the role of magnetic resonance angiography is advocated, taking into consideration the enormous amount of radiation exposure with other modalities. Complications of c-TA include cardiovascular, pulmonary, neurological and those arising secondary to long-term steroid and immunosuppression therapy.

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Section: Clinical Manifestationsmentioning

confidence: 99%

Childhood‐onset Takayasu arteritis: an update

et al. 2015

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“…18 An absence of the physical findings related to vasculitic lesions, common in the pre-pulseless period, should not rule out the disease. 18 The commonest mode of presentation of TA among Indian-origin patients is hypertension (83%), 7 along with headache and left ventricular hypertrophy 4,6,7 as in this case. Her hypertension is explained as occurring as a result of AR, not coarctation, as the stenosis only involved the more distal part of the descending thoracic aorta and not the usual site of coarctation, which is just distal to the left subclavian artery.…”

Section: Discussionmentioning

confidence: 61%

Pre-pulseless Takayasu Arteritis Presenting with Hypertension

Islam

Nasrin²,

Cader³

et al. 2017

J. Bangladesh Coll. Phys.

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Takayasu arteritis (TA) is a chronic granulomatous vasculitic disease of the aorta and its major branches, predominantly affecting young females of Asian origin. Also known as Aortic arch syndrome, the condition has been better documented as the 'Pulse less disease' leading to claudication, bruits, absent or reduced brachial or radial pulses and aortic incompetence.However, a 'prepulseless' stage of TA exists, characterized by non-specific constitutional symptoms, hypertension and CASE REPORTS raised inflammatory markers. We report the case of an 18-year-old Bangladeshi female presenting with hypertension, moderate to severe aortic regurgitation (AR) and fever, diagnosed and treated as a case of pre-pulseless TA.

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“…4 Positive mantoux reaction has been described in cases of Takayasu vasculitis as a result of altered immunological response in these cases. 7,8 Tuberculosis and Takayasu vasculitis are both relatively common in SoutheEast Asian countries as compared to western countries, so it is very important to look for presence of tuberculosis in a case of Takayasu vasculitis. Though our patient had elevated ESR and a strongly positive Mantoux reaction, we did not to find a focus of tuberculosis despite detailed investigations for the same.…”

Section: Discussionmentioning

confidence: 99%