Takayasu Arteritis in Children: Preliminary Experience with Cyclophosphamide Induction and Corticosteroids Followed by Methotrexate

Özen, Seza; Düzova, Ali; Bakkaloğlu, Ayşı̇n; Bilginer, Yelda; Çil, Barbaros; Demircin, Metin; Davin, Jean Claude; Bakkaloḡlu, M.

doi:10.1016/j.jpeds.2006.10.059

Cited by 98 publications

(42 citation statements)

References 13 publications

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“…Ozen et al, 52 in their series of six children with c-TA, have successfully used CYC and steroids for induction followed by MTX for maintenance as an effective and safe regime. We have been consistently using MMF in adult TA and c-TA, with good outcomes.…”

Section: Treatmentmentioning

confidence: 99%

Childhood‐onset Takayasu arteritis: an update

et al. 2015

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Childhood-onset Takayasu arteritis (c-TA) is a distinct subset affecting a wide age group, ranging from young infants to adolescents and it differs from adult TA in many aspects. There is scarcity of data on c-TA worldwide. The disease is classified using the European League Against Rheumatism/Pediatric Rheumatology International Trials Organization/Pediatric Rheumatology European Society criteria. The non-specific nature of presenting complaints and lack of appropriate biomarkers delay the early diagnosis of this illness and many children present with complications, which become irreversible once they set in. One of the largest cohorts of 40 children with c-TA from our center reports hypertension as the commonest presenting feature. Systemic symptoms like headache, fever and weight loss are also described. Assessment of disease in c-TA is done by correlating clinical features with raised inflammatory markers. Advanced imaging plays an important role in diagnosis. In c-TA, the role of magnetic resonance angiography is advocated, taking into consideration the enormous amount of radiation exposure with other modalities. Complications of c-TA include cardiovascular, pulmonary, neurological and those arising secondary to long-term steroid and immunosuppression therapy.

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Section: Treatmentmentioning

confidence: 99%

Childhood‐onset Takayasu arteritis: an update

et al. 2015

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“…Los corticoides son el grupo de medicamentos más utilizados para controlar la enfermedad activa y lograr la remisión, pudiendo usarse bolos de Metilprednisolona y corticoides orales a dosis altas para luego continuar con descenso progresivo, por largo tiempo. Se utilizan además otros inmunosupresores ahorradores de corticoides como agentes citotóxicos (ciclofosfamida, metotrexato, azatioprina, (7,(31)(32)(33)(34) micofenolato) , y en casos de poca respuesta a los mismos: agentes biológicos como tocilizumab (anti- (35) IL 6) , Rituximab (anti CD20 expresado en la (36) superficie de linfocitos B) , anti-Factor de Necrosis Tumoral (FNT) como etanercept, infliximab, ( 3 4 , 3 7 , 3 8 ) a d a l i m u m a b . L o s p r o c e d i m i e n t o s cardiovasculares descriptos con más frecuencia son cirugía de injerto (bypass), angioplastia percutánea con balón, angioplastia y stents, recorte de aneurisma (7,(39)(40)(41) y revascularización, con diferentes resultados .…”

Section: Discussionunclassified

Takayasu arteritis in a child: A case report

Morel

Marecos

Ávila

et al. 2017

Pediatr. (Asunción)

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“…Remission has been achieved in 60% of patients treated with glucocorticoids alone (1,10). Percutaneous transluminal angioplasty (PTA) is the most common palliative procedure.…”

Section: Discussionmentioning

confidence: 99%