Takayasu Arteritis: Recent Developments

Villon, Maria L F Zaldivar; Rocha, José Aurillo; Espinoza, Luis R.

doi:10.1007/s11926-019-0848-3

Cited by 68 publications

(48 citation statements)

References 57 publications

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“…TAK is a rare, large-vessel vasculitis mostly seen in young women, and female-to-male ratios range between 5 and 12 to 1, although the reason for this predominance is unknown. In the past, TAK was mostly reported in Asian populations, but it is now known to be distributed worldwide ( 4 ). The associations between TAK and HLA-B*52 have been established, as HLA-B*52 is the only gene that relates to TAK beyond ethnicity.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, it is obvious that TAK shares a high prevalence with HLA-B*52 in Asia ( 6 ). The etiology of TAK has not yet been established, although previous studies have shown the involvement of several triggers (genetic predisposition, environmental triggers, microorganisms, and/or their antigenic components), pathogenic effector T cells, macrophages, and decreases in Treg cells ( 4 ). In 2018, Terao et al published a study suggesting an interactive effect between leukocyte immunoglobulin-like receptor (LILR) A3 and HLA-B*52 in TAK, as HLA-B expresses HLA class I molecules on the surface of organ tissue cells ( 16 ).…”

Section: Discussionmentioning

confidence: 99%

“…For this reason, the presence or absence of IK is a critical factor in the classification of CS, but other probable inflammatory eye diseases in atypical CS are due to small vessel vasculitis. In contrast, the ocular manifestations in TAK are associated with flow-limited carotid or vertebral arteries with retinal involvement due to hypoperfusion from an occluded internal carotid artery ( 4 ).…”

Section: Discussionmentioning

confidence: 99%

“…Takayasu arteritis (TAK) is a rare, chronic large-vessel vasculitis of the aorta and its major branches often found in young women. Ocular manifestations and vision loss associated with concomitant flow-limiting of the carotid or vertebral artery may occur ( 4 ), but sensorineural hearing loss (SNHL), often due to steroid-dependent sensorineural hearing loss (SDSNHL), is rare ( 5 ). A firm association between TAK and HLA-B*52 has been established ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

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Familial HLA-B*52 Vasculitis: Maternal, Atypical Cogan's Syndrome with Takayasu Arteritis-mimicking Aortitis and Filial Takayasu Arteritis

et al. 2020

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Cogan's syndrome (CS), a rare vasculitis characterized by non-syphilitic, interstitial keratitis and Ménièrelike attacks, is classified into "typical" and "atypical" forms, while Takayasu arteritis (TAK) is a rare largevessel vasculitis associated with HLA-B*52. Very few cases meet both the CS and TAK classification criteria. We herein report a 53-year-old woman diagnosed with atypical CS and aortitis similar to TAK. Her 25-yearold daughter manifested TAK without symptoms of CS, and both are HLA-B*52 positive. Our case highlights the difficulties of distinguishing aortitis with atypical CS from aortitis with TAK.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Familial HLA-B*52 Vasculitis: Maternal, Atypical Cogan's Syndrome with Takayasu Arteritis-mimicking Aortitis and Filial Takayasu Arteritis

et al. 2020

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“…It involves the aorta and its main branches predominantly, and leads to vascular thickness, stenosis and occlusion [1]. In addition, TA occurs preferentially in young (20-40 years) women and has a relatively high prevalence in Asian countries compared with that in the USA and European countries [2].…”

Section: Introductionmentioning

confidence: 99%

Involvement of the pulmonary arteries in patients with Takayasu arteritis

Kong

et al. 2020

Preprint

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Background: Takayasu arteritis (TA) is a large-vessel vasculitis that can involve pulmonary arteries (PAs). We studied multiple clinical characteristics related to pulmonary artery involvement (PAI) in TA patients.Methods: We enrolled 216 patients with TA from a large prospective cohort. PAI was assessed in each patient based on data from magnetic resonance angiography/computed tomography angiography. Pulmonary hypertension, cardiac function, and pulmonary parenchymal abnormalities were evaluated further in patients with PAI based on echocardiography, New York Heart Association Functional Classification and pulmonary computed tomography, respectively. These abnormalities related to PAI were followed up to evaluate treatment effects.Results: PAI was detected in 56/216 (25.93%) patients, which involved the pulmonary trunk, main PAs and small vessels in the lungs. Among patients with PAI, 28 (50%) patients were accompanied by pulmonary hypertension, which was graded as ‘severe’ in 9 (16.07%), ‘moderate’ in 10 (17.86%) and mild in 9 (16.07%). Forty (71.43%) patients had cardiac insufficiency (IV: 6, 10.71%; III: 20, 35.71%; II: 14, 25.00%). Furthermore, 21 (37.50%) patients presented with abnormal parenchymal features in the area corresponding to PAI (e.g., the mosaic sign, infarction, bronchiectasis). During follow-up, two patients died due to abrupt pulmonary thrombosis. In the remaining patients, the abnormalities mentioned above improved partially after routine treatment.Conclusions: PAI is very common in TA patients. PAI can cause pulmonary hypertension, cardiac insufficiency and pulmonary parenchymal lesions, which worsen the prognosis.

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Takayasu Arteritis: a Systematic Review and Meta‐Analysis of Test Accuracy and Benefits and Harms of Common Treatments

Dua

Kalot

Husainat

et al. 2021

ACR Open Rheumatology

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Objective Takayasu’s arteritis (TAK) is a granulomatous large‐vessel vasculitis primarily affecting the aorta and its proximal branches. TAK can be a difficult disease to diagnose and manage given the rarity of the disease as well as current limitations in biomarkers, imperfect imaging modalities, and few randomized controlled trials. Methods In developing the American College of Rheumatology/Vasculitis Foundation guideline for the management of TAK, we performed an extensive systematic literature review to guide our recommendations. We included RCTs first. When RCTs were not available, we included observational studies that reported on patient‐important outcomes for the intervention and comparison. When studies with comparative data were not available, we included case series that present patient‐important outcomes for either the intervention or the comparison. Results Three hundred forty‐seven articles were included for full review to answer 27 population, intervention, comparison, and outcome questions related to TAK. Ten studies were evaluated that addressed the use of glucocorticoids (GCs), non‐GC nonbiologic therapies, as well as biologics in treating TAK. A total of 33 studies, including 8 comparative studies, were included to determine the test accuracy of commonly available diagnostic tests for TAK. Conclusion This comprehensive systematic review synthesizes and evaluates the benefits and harms of different treatment options and the accuracy of commonly used tests for the management of TAK.

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Takayasu Arteritis: Recent Developments

Cited by 68 publications

References 57 publications

Familial HLA-B*52 Vasculitis: Maternal, Atypical Cogan's Syndrome with Takayasu Arteritis-mimicking Aortitis and Filial Takayasu Arteritis

Familial HLA-B*52 Vasculitis: Maternal, Atypical Cogan's Syndrome with Takayasu Arteritis-mimicking Aortitis and Filial Takayasu Arteritis

Involvement of the pulmonary arteries in patients with Takayasu arteritis

Takayasu Arteritis: a Systematic Review and Meta‐Analysis of Test Accuracy and Benefits and Harms of Common Treatments

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