Takayasu's Arteritis and Its Association With Mycobacterium Tuberculosis: A Systematic Review

Magar, Manusha Thapa; Kafle, Sunam; Poudel, Arisa; Patel, Priyanka; Cancarevic, Ivan

doi:10.7759/cureus.16927

Cited by 8 publications

(5 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The differential diagnosis includes other vasculitic causes of ocular ischemia – polyarteritis nodosa, Wegener’s granulomatosis, and Kawasaki’s disease. [ 7 ] The association of tuberculosis with TA has been documented;[ 63 ] however, we could not find an association of ocular tuberculosis with TA. Asymmetric DR attributable to TA has been documented by Burgos-Blasco B et al .…”

Section: Discussionmentioning

confidence: 55%

Posterior segment manifestations of Takayasu arteritis: A narrative review

Sharma,

Rishi,

Rishi

et al. 2024

Indian Journal of Ophthalmology

View full text Add to dashboard Cite

Ocular symptoms can be the presenting manifestation of Takayasu arteritis (TA) or could be indicative of disease reactivation. A review of published literature related to posterior segment manifestations of TA by using the keywords “Takayasu arteritis,” “ophthalmic manifestations,” “retina,” “retinopathy,” “ocular,” “optic nerve,” and “optic neuropathy” was performed. In total, 62 case reports and 12 case series were included. The majority of the articles were from Asia (n = 47, 64%). Females outnumbered males in the ratio of 7:1. The mean age of patients was 33 years (range: 8–78 years, SD: 13.5 years). In 58% (n = 41 out of 71) cases, ocular symptoms were the presenting manifestation of the underlying disease. Hypotensive retinopathy was found in 70% of eyes, and hypertensive retinopathy was found in 27%. The mean presenting visual acuity (VA) was +1.03 logMAR (range: −0.12 to 3, SD: 1.07), and at the final follow-up was +1.02 logMAR (range: −0.12 to 3, SD 1.17). VA improved in 34% (n = 29/86), remained stable in 45% (39/86), and worsened in 21% (18/86). The mean follow-up was 9 months (range: 0.5–204, SD: 16 months).

show abstract

Section: Discussionmentioning

confidence: 55%

Posterior segment manifestations of Takayasu arteritis: A narrative review

Sharma,

Rishi,

Rishi

et al. 2024

Indian Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…Firstly, TAK exhibits a higher prevalence in populations with high rates of TB infection. Furthermore, previous evidence suggests that TB infection may act as a trigger for the development of TAK 51 . The arterial pathology of TAK showcases granulomatous lesions, similar to those observed in TB.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of tuberculosis infection among patients with Takayasu arteritis: a meta-analysis of observational studies

Li,

Zhou,

et al. 2023

Sci Rep

View full text Add to dashboard Cite

To clarify the risk of tuberculosis (TB) infection in patients with Takayasu arteritis (TAK). In this study, we conducted a comprehensive search across multiple databases, including PubMed, Web of Science, Embase, Cochrane, and Medline, from the inception of the Literature Library to May 16, 2023. Using a specific set of keywords, including “Takayasu Arteritis”, “Tuberculosis”, and “Mycobacterium tuberculosis”, the main objective of this search was to identify all relevant observational studies, including case-control studies, cohort studies, and cross-sectional studies, that report the prevalence of TB in individuals diagnosed with TAK. Two independent evaluators rigorously screened the studies, extracted data, and assessed the study quality using the Joanna Briggs Institute (JBI) critical appraisal tools. Statistical analyses were conducted using R software version 4.3.0, which allowed for the synthesis of prevalence and subgroup analyses. Subgroup analyses were stratified based on quality scores, World Health Organization regional categorizations, and TB categories. Assessment of publication bias was performed using a funnel plot. The study included a total of 30 studies with 5548 participants. The findings showed that individuals with TAK exhibited an average prevalence of TB infection at 31.27% (95% CI 20.48–43.11%). Significantly, the prevalence of TB infection demonstrated notable regional disparities, ranging from 16.93% (95% CI 7.71–28.76%) in the Western Pacific Region to 63.58% (95% CI 35.70–87.66%) in the African Region. Moreover, the study revealed that patients with TAK displayed a high prevalence of latent TB infection (LTBI) at 50.01% (95% CI 31.25–68.77%) and active TB at 14.40% (95% CI 9.03–20.68%). The high heterogeneity observed in the data highlights significant variability in TB infection rates among the populations studied, with the African Region exhibiting the highest rates. The study concludes that there is a high prevalence of TB infection in the TAK population, with regional variations. Consideration should be given to implementing rigorous TB screening measures and preventive interventions specifically tailored for the TAK population.

show abstract

“…The association between tuberculosis (TB) and TAK has long been suspected but there lacks high-quality evidence to support this assumption [ 3 , 4 ]. Neither the incidence of TB in TAK patients nor the role of TB infection in the pathogenesis of TAK has been elucidated due to disease rarity [ 5 ]. Furthermore, anti-rheumatic medications have long been recognized to increase the risk of TB infection or LTBI reactivation [ 6–8 ].…”

Section: Introductionmentioning

confidence: 99%

Incidence, risk factors for active tuberculosis infection and changes of IGRA in patients with Takayasu arteritis: a prospective cohort study

Peng,

Li,

Rong

et al. 2024

Emerging Microbes & Infections

View full text Add to dashboard Cite

There is limited evidence to support the association between tuberculosis (TB) and the occurrence of Takayasu arteritis (TAK). To investigate the incidence of active TB (ATB) in TAK and explore the impact of anti-rheumatic therapy on the occurrence of ATB or reactivation of Latent TB infection (LTBI) and their effect on interferon-γ release assay (IGRA) results, we conducted a prospective study based on the Chinese Registry for Systemic Vasculitis cohort. The standard incidence ratio (SIR) was calculated and stratified by age. Kaplan–Meier analysis was used to determine the effect of variables on ATB or LTBI reactivation in patients with TAK. Data from 825 patients with TAK in the registry were analysed. During a median follow-up of 5 years, 5 patients developed ATB with a crude incidence of 154 (95%CI:57–381) person-years/100,000. The SIR was 5.59 (95%CI:1.81–13.04). Glucocorticoids and conventional disease-modifying anti-rheumatic drugs (cDMARDs) did not increase the risk of ATB or LTBI reactivation ( P > 0.05). However, the use of tumour necrosis factor inhibitor (TNFi) increased the risk of ATB in patients with LTBI ( P < 0.001). Furthermore, the value of the IGRA assay decreased after treatment ( P < 0.05). In conclusion, the incidence of TB infection is markedly increased in patients with TAK and patients with TAK are at high risk of developing ATB. Treatment with glucocorticoids and cDMARDs does not significantly increase the risk for ATB in patients with TAK. Moreover, IGRA may have limited effectiveness in monitoring ATB infection or LTBI reactivation in patients with TAK.

show abstract

Takayasu's Arteritis and Its Association With Mycobacterium Tuberculosis: A Systematic Review

Cited by 8 publications

References 24 publications

Posterior segment manifestations of Takayasu arteritis: A narrative review

Posterior segment manifestations of Takayasu arteritis: A narrative review

Prevalence of tuberculosis infection among patients with Takayasu arteritis: a meta-analysis of observational studies

Incidence, risk factors for active tuberculosis infection and changes of IGRA in patients with Takayasu arteritis: a prospective cohort study

Contact Info

Product

Resources

About