“Take a Number”—Precision Monitoring Directs Precision Therapy

Kochanek, Patrick M.; Jha, Ruchira M.; Clark, Robert S. B.

doi:10.1007/s12028-020-00941-3

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From Epidemiology To Patient Management: Current Knowledge A1

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2021

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“…Furthermore, in children, defining adequate ICP and CPP control is more complex than that in adults, because of different and less well-established normative thresholds for ICP and blood pressure ( 34 , 35 ). Thus, we may need to tailor thresholds to age, baseline values, injury phenotype (diffuse or focal), and the therapeutic approach (i.e., the ICP threshold to administer hyperosmolar therapy likely differs from that used to perform a craniectomy) ( 36 ).…”

Section: From Epidemiology To Patient Management: Current Knowledge Amentioning

confidence: 99%

Addressing Key Clinical Care and Clinical Research Needs in Severe Pediatric Traumatic Brain Injury: Perspectives From a Focused International Conference

et al. 2021

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Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in children and adolescents. Survivors of severe TBI are more prone to functional deficits, resulting in poorer school performance, poor health-related quality of life (HRQoL), and increased risk of mental health problems. Critical gaps in knowledge of pathophysiological differences between children and adults concerning TBI outcomes, the paucity of pediatric trials and prognostic models and the uncertain extrapolation of adult data to pediatrics pose significant challenges and demand global efforts. Here, we explore the clinical and research unmet needs focusing on severe pediatric TBI to identify best practices in pathways of care and optimize both inpatient and outpatient management of children following TBI.

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Section: From Epidemiology To Patient Management: Current Knowledge Amentioning

confidence: 99%