Taking 200 mg Vitamin C Three Times per Day Improved Extraction Socket Wound Healing Parameters: A Randomized Clinical Trial

Abstract

Vitamin C is essential for wound healing. However, there are no reports concerning the effect of a different dose of vitamin C on extraction wound size clinically. Therefore, the aim of this study was to investigate the effect of different oral vitamin C doses on extraction wound healing. A split-mouth, double-blind randomized clinical trial was performed in 42 patients who underwent symmetric bilateral noninfected premolar extraction. The patients were randomly divided into 3 groups, namely, P/600, P/1,500, and 600/1,500 (14 patients for each group); P/600: placebo vs. 600 mg vitamin C/d, P/1,500: placebo vs. 1,500 mg vitamin C/d, and 600/1,500: 600 mg vitamin C/d vs. 1,500 mg vitamin C/d. Patients were prescribed placebo or/and vitamin C three times a day for 10 days after each tooth extraction. Extraction wound size and pain score were evaluated. The wound assessment was performed on day 0, 7, and 21; and then the tooth on the other side was extracted using the same protocol. Pain score was recorded on the first three days after extraction. The reduced size of mesiodistal extraction wound in percentage reduction between day 0 and 7 of teeth receiving vitamin C 600 mg/d was more than that in placebo ( P < 0.05 ). Pain scores on day 1–3 of teeth receiving vitamin C 600 mg/d were significantly lower than the placebo side ( P < 0.05 ). Taking oral vitamin C 600 mg/d over three doses for 10 days after tooth extraction enhances extraction wound healing by reducing mesiodistal extraction wound and reduces postoperative pain.

Impact of vitamin C on the reduction of opioid consumption after an emergency department visit for acute musculoskeletal pain: a double-blind randomised control trial protocol

“…27 One study using 500 mg intravenously two times a day up to the third day after surgery also demonstrated less pain intensity and opioid consumption with vitamin C. 28 Taking 200 mg orally of vitamin C three times a day, for 10 days after tooth extraction, was associated with reduced postoperative pain. However, this small study did not find any difference between 600 mg and 1500 mg per day of vitamin C. 29 The only study performed in a non-postoperative acute pain context showed that intravenous administration of vitamin C was effective in reducing the incidence of post-herpetic neuralgia. 30 The efficacy of vitamin C to prevent specific types of chronic pain, notably in complex regional pain syndromes (CRPS), has been reported in a meta-analysis.…”

“…Taking 200 mg orally of vitamin C three times a day, for 10 days after tooth extraction, was associated with reduced postoperative pain. However, this small study did not find any difference between 600 mg and 1500 mg per day of vitamin C 29. The only study performed in a non-postoperative acute pain context showed that intravenous administration of vitamin C was effective in reducing the incidence of post-herpetic neuralgia 30…”

A Systematic Review on the Role of Vitamin C in Tissue Healing

“…Among the 18 included studies, there were six studies treating pressure ulcers, with a total of 234 patients [ 9 , 10 , 11 , 12 , 13 , 14 ]. Three studies involved a total of 233 people receiving treatment for dental extractions [ 15 , 16 , 17 ]. Two studies involved a total of 41 patients receiving treatment for foot ulceration [ 6 , 18 ].…”

“…Pisalsitsakul et al performed a double-blind randomised controlled trial with 32 patients following a tooth extraction. The study consisted of three paired groups with a total of 128 extraction sites analysed [ 16 ]. The groups were placebo and administration of 600 mg vitamin C or 1500 mg vitamin C. All dosages were taken daily.…”