Drawing from a Job-Demand and Resource (J-DR) model and Conservation of Resources theory (COR), this study aims to examine the moderating role of affective commitment in relation to work-family interface (WFI), emotional exhaustion(EE), and turnover intention. Particularly, this study examines how the influence of affective commitment contribute in buffering the impact of WFI [which includes work-family conflict (WFC) and family-work conflict(FWC)] on emotional exhaustion and turnover intention. Data were collected from 202 medical doctors from various clinical departments across four Malaysian public hospitals. A self-report survey was administered to clinical doctors, excluding those in management, research, and training institutions. Partial Least Square-Structural Equation Modelling (PLS-SEM) version 3.2.8 was employed for data analysis. As hypothesised, WFI (WFC/FWC) and emotional exhaustion are positively associated with turnover intentions.The findings also revealed that emotional exhaustion increased when WFC was amplified but not FWC and that this relationship was stronger when affective commitment was low and weaker when it was high. The empirical study revealed that affective commitment may be considered as protective resources for doctors. Furthermore, the results showed that high work-family interface should not have a notable impact when doctors have a high affective commitment thus reducing emotional exhaustion and turnover intentions.