Takotsubo cardiomyopathy and elevated troponin levels following cerebral seizure

CNS disease triggering Takotsubo stress cardiomyopathy

“…No systematic prospective studies are available. The largest series included only five patients [52]. Only case reports are available ( Table 2).…”

Prevalence and Risk Factors of Stress Cardiomyopathy After Convulsive Status Epilepticus in ICU Patients

“…Subsequently, several case reports suggested that epilepsy or CSE could result in SC (10)(11)(12)(13)(14)(15)(16). Nevertheless, the frequency of SC in patients with CSE remains currently unknown and may be underestimated (17).…”

Letter – Seizures and the neuro‐cardio‐endocrine axis

“…To us and as stated by Hocker et al, however, particularly tonic-clonic seizures and SE might lead to overflowing sympathetic activation potentially resulting in myocyte damage and consecutive cardiac contractile dysfunction or susceptibility to arrhythmias (Zijlmans et al, 2002;Schneider et al, 2010;Eskandarian et al, 2011;Stollberger et al, 2011). Furthermore, the neurocardio-endocrine axis has attracted attention, since acute neurologic insults (including seizures) have been reported to be associated with the so-called takotsubo cardiomyopathy (TC) several years ago (Schneider et al, 2010;Stollberger et al, 2011). TC is clinically characterized by chest pain and dyspnea paralleled by elevation of cardiac enzyme levels and transient wall-motion abnormality.…”